Results 61 to 70 of about 432,342 (201)
The GluN3A Subunit Exerts a Neuroprotective Effect in Brain Ischemia and the Hypoxia Process
ASN Neuro, 2013 NMDARs ( N -methyl-d-aspartate receptors) mediate the predominantly excitatory neurotransmission in the CNS (central nervous system). Excessive release of glutamate and overactivation of NMDARs during brain ischemia and the hypoxia process are causally ...
Hui Wang +5 more
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Neurobiology of Disease, 2003 Stroke is a devastating condition occurring in at least 1 in 4000 live births in the neonatal period. Since hypoxia-inducible factor (HIF)-1α can modulate ischemic injury via induction of target genes that may protect cells against ischemia, and is ...
Dezhi Mu +6 more
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Stem cells for brain repair in neonatal hypoxia–ischemia [PDF]
Child's Nervous System, 2013 Neonatal hypoxic-ischemic insults are a significant cause of pediatric encephalopathy, developmental delays, and spastic cerebral palsy. Although the developing brain's plasticity allows for remarkable self-repair, severe disruption of normal myelination and cortical development upon neonatal brain injury are likely to generate life-persisting sensory ...
Chicha, L., Smith, T., Guzman, R.
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The effects of hyperglycaemic hypoxia on rectification in rat dorsal root axons [PDF]
, 1994 1. Electrotonic responses to 150 ms current pulses were recorded from isolated rat dorsal roots incubated for at least 3 h with either normal (5 mM) or high (25 mM) D-glucose solutions, and with either normal (25 mM) or low (5 mM) bicarbonate ...
U Schneider +5 more
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PLoS ONE, 2012 Perinatal hypoxia-ischemia is a major cause of acute mortality in newborns and cognitive and motor impairments in children. Cerebral hypoxia-ischemia leads to excitotoxicity and necrotic and apoptotic cell death, in which mitochondria play a major role ...
Cláudia S F Queiroga +5 more
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Apoptosis in a Neonatal Rat Model of Cerebral Hypoxia-Ischemia [PDF]
Stroke, 1998 Background and Purpose —The mechanisms of excitotoxic cell death in cerebral ischemia are poorly understood. In addition to necrosis, apoptotic cell death may occur. The purpose of this study was to determine whether an established model of cerebral hypoxia-ischemia in the neonatal rat demonstrates any features ...
M R, Pulera +7 more
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The Role of Endothelin in Mediating Ischemia/Hypoxia-Induced Atrial Natriuretic Peptide Release
, 2015 The aim of the present study was to investigate the putative role of endothelin (ET) in mediating ischemia/hypoxia-induced ANP release utilizing exogenous ET-1 or ET receptor antagonists (BQ-123 or Bosentan).
Oliver, J M, Zhang, Yi, Horowitz, John D
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Data in Brief, 2018 The data contain body weights, plasma free fatty acids concentrations and cardiac uncoupling protein-3 protein levels for wild-type and mdx mice. The data provide heart rates, left ventricular contractile functions, coronary flow, phosphocreatine ...
Wen Zhang +4 more
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Hypoxia-induced signaling in angiogenesis : role of mTOR, HIF and Angiotensin II [PDF]
, 2007 This thesis includes the work of four different projects I have been following during my time as a PhD student; (1) the characterization of mTOR-associated signaling and endothelial cell proliferation in response to hypoxia, and (2) identification of ...
Petrimpol, Marco Renato
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Effects of intermittent versus chronic hypoxia on myocardial ischemic tolerance
, 2013 Hypoxia, or low supply of oxygen with respect to need, represents a critical risk factor that augments severity and impairs outcome of myocardial ischemia. However, systemic hypoxia is sometimes a cardioprotective rather than risk factor. Three different
Samaja M., Veicsteinas A., Milano G.
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