Inhalation of high-concentration hydrogen gas attenuates cognitive deficits in a rat model of asphyxia induced-cardiac arrest. [PDF]
, 2019 Cognitive deficits are a devastating neurological outcome seen in survivors of cardiac arrest. We previously reported water electrolysis derived 67% hydrogen gas inhalation has some beneficial effects on short-term outcomes in a rat model of global brain
Alexander +32 more
core +2 more sources
Analysis of GWAS-Derived Schizophrenia Genes for Links to Ischemia-Hypoxia Response of the Brain
Frontiers in Psychiatry, 2020 Obstetric complications (OCs) can induce major adverse conditions for early brain development and predispose to mental disorders, including schizophrenia (SCZ).
Rainald Schmidt-Kastner +7 more
doaj +1 more source
Metabolic Changes Following Perinatal Asphyxia: Role of Astrocytes and Their Interaction with Neurons [PDF]
, 2016 Perinatal Asphyxia (PA) represents an important cause of severe neurological deficits including delayed mental and motor development, epilepsy, major cognitive deficits and blindness.
Barreto, George E. +5 more
core +1 more source
MicroRNA-210 Suppresses Junction Proteins and Disrupts Blood-Brain Barrier Integrity in Neonatal Rat Hypoxic-Ischemic Brain Injury. [PDF]
, 2017 Cerebral edema, primarily caused by disruption of the blood-brain barrier (BBB), is one of the serious complications associated with brain injury in neonatal hypoxic-ischemic encephalopathy (HIE).
Dasgupta, Chiranjib +4 more
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Neuronal cell death in neonatal hypoxia‐ischemia [PDF]
Annals of Neurology, 2011 AbstractPerinatal hypoxic‐ischemic encephalopathy (HIE) is a significant cause of mortality and morbidity in infants and young children. Therapeutic opportunities are very limited for neonatal and pediatric HIE. Specific neural systems and populations of cells are selectively vulnerable in HIE; however, the mechanisms of degeneration are unresolved ...
Frances J, Northington +2 more
openaire +2 more sources
The change in the hypoxia resistance at chronic cerebral ischemia
Бюллетень сибирской медицины, 2008 Hypoxia and its related oxidate stress are the direct cause of the neural damage due to chronic cerebral ischemia. Resistance to hypoxia and oxidate stress is the main marker of the human and brain adaptation to chronic ischemia.Hypoxia resistance and ...
Ye. A. Antipenko, A. V. Gustov
doaj +1 more source
KPNA2 promotes angiogenesis by regulating STAT3 phosphorylation
Journal of Translational Medicine, 2022 Purpose Angiogenesis is involved in many pathological and physiological processes and is mainly driven by hypoxia. Karyopherin subunit alpha 2 (KPNA2), a member of the nuclear transport protein family, was recently shown to be induced by hypoxia in ...
Yujie Jia +3 more
doaj +1 more source
Long-term deficits in cortical circuit function after asphyxial cardiac arrest and resuscitation in developing rats [PDF]
, 2017 Cardiac arrest is a common cause of global hypoxic-ischemic brain injury. Poor neurologic outcome among cardiac arrest survivors results not only from direct cellular injury but also from subsequent long-term dysfunction of neuronal circuits.
Clark, Robert S.B. +5 more
core +2 more sources
Inhaled 45–50% argon augments hypothermic brain protection in a piglet model of perinatal asphyxia
Neurobiology of Disease, 2016 Cooling to 33.5 °C in babies with neonatal encephalopathy significantly reduces death and disability, however additional therapies are needed to maximize brain protection.
Kevin D. Broad +14 more
doaj +1 more source
Ilexsaponin A attenuates ischemia-reperfusion-induced myocardial injury through anti-apoptotic pathway. [PDF]
PLoS ONE, 2017 The protective effects of ilexsaponin A on ischemia-reperfusion-induced myocardial injury were investigated. Myocardial ischemia/reperfusion model was established in male Sprague-Dawley rats. Myocardial injury was evaluated by TTC staining and myocardial
Shuang-Wei Zhang +6 more
doaj +1 more source