Results 1 to 10 of about 4,669 (158)

Mitigating organophosphate nerve agent, soman (GD), induced long-term neurotoxicity: Saracatinib, a Src Tyrosine Kinase inhibitor, as a potential countermeasure [PDF]

Journal of Neuroinflammation
Background Acute exposure to soman (GD), an organophosphate nerve agent (OPNA), irreversibly inhibits acetylcholinesterase (AChE), induces seizures, and could be fatal if not treated immediately.
Nyzil Massey, Suraj S. Vasanthi, Claire Holtkamp, Christina Meyer, Nikhil S. Rao, Luis G. Gimenez-Lirola, Chong Wang, Hyunmook Im, Avinash S. Bevoor, Sridhar Kannurpatti, Thimmasettappa Thippeswamy   +10 more
doaj   +2 more sources

Proteomics Reveals Mechanisms of Metabolic Dysregulation in Soman Neurotoxicity [PDF]

Toxics
Soman, an organophosphorus nerve agent, induces neurotoxicity primarily by inhibiting acetylcholinesterase, triggering a series of pathological events including cholinergic crisis, seizures, calcium overload, oxidative stress, mitochondrial dysfunction ...
Xing-Xing Zong, Qian Jin, Tong Shi, Ruihua Zhang, Jingjing Shi, Chen Wang, Liqin Li   +6 more
doaj   +2 more sources

(-)-Phenserine attenuates soman-induced neuropathology. [PDF]

PLoS ONE, 2014
Organophosphorus (OP) nerve agents are deadly chemical weapons that pose an alarming threat to military and civilian populations. The irreversible inhibition of the critical cholinergic degradative enzyme acetylcholinesterase (AChE) by OP nerve agents ...
Jun Chen, Hongna Pan, Cynthia Chen, Wei Wu, Kevin Iskandar, Jeffrey He, Tetsade Piermartiri, David M Jacobowitz, Qian-Sheng Yu, John H McDonough, Nigel H Greig, Ann M Marini   +11 more
doaj   +4 more sources

Cystamine reduces neurodegeneration and epileptogenesis following soman-induced status epilepticus in rats [PDF]

Experimental Biology and Medicine
Acute exposure to a seizure-inducing dose of an organophosphorus nerve agent inhibits acetylcholinesterase, leading to pharmacoresistance if benzodiazepine treatment is delayed.
Abiel K. Biney, Caroline R. Schultz, Michael F. Stone, Donna A. Nguyen, Annie Wang, Marcio de Araujo Furtado, Lucille A. Lumley   +6 more
doaj   +2 more sources

Soman induces endoplasmic reticulum stress and apoptosis of cerebral organoids via the GRP78‐ATF6‐CHOP signaling pathway [PDF]

FEBS Open Bio
Soman is an organophosphorus compound that induces neurotoxicity. In addition to its direct toxic effects resulting from acetylcholine accumulation, neurotoxicity may also be exacerbated by inducing endoplasmic reticulum (ER) stress.
Yue Wei, Zhanbiao Liu, Jingjing Shi, Qian Jin, Wenqian Chen, Xuejun Chen, Liqin Li, Hui Chen   +7 more
doaj   +2 more sources

Dual targeting of iNOS and Src tyrosine kinase as a superior therapeutic strategy against soman-induced long-term neurotoxicity: multimodal biomarker, imaging, and neurobehavioral outcome analyses [PDF]

Acta Neuropathologica Communications
Acute exposure to the organophosphate nerve agent (OPNA) soman (GD) triggers severe and persistent brain injury characterized by seizures, oxidative stress, and structural and functional network alterations, collectively described as the brain’s “SOS ...
Nyzil Massey, Suraj S. Vasanthi, Christina Meyer, Nikhil S. Rao, Daniel R. Thedens, Chong Wang, Sridhar Kannurpatti, Thimmasettappa Thippeswamy   +7 more
doaj   +2 more sources

Ultra-Sensitive Analysis of Organophosphorus Compounds by Comparative GC-FPD and GC-ICP-MS: Implications for Chemical Warfare Agent Detection [PDF]

Molecules
Organophosphorus chemical warfare agents such as sarin (GB), soman (GD), and cyclosarin (GF) rank among the most toxic substances known, making trace-level detection critical for public and military safety.
Michał Wiktorko, Piotr Kot, Anna Puchała, Patrycja Bryczek-Wróbel, Klaudia Izabela Rzadkowska, Barbara Wiaderek   +5 more
doaj   +2 more sources

Anticonvulsants for soman-induced seizure activity

Journal of Biomedical Science, 1999
This report describes studies of anticonvulsants for the organophosphorus (OP) nerve agent soman: a basic research effort to understand how different pharmacological classes of compounds influence the expression of seizure produced by soman in rats, and a drug screening effort to determine whether clinically useful antiepileptics can modulate soman ...
Tsung-Ming Shih, John H Mcdonough, Irwin Koplovitz   +2 more
exaly   +3 more sources

Proinflammatory cytokines, oxidative stress, and organ function as biomarkers of soman (GD) chronic neurotoxicity [PDF]

Scientific Reports
Organophosphate (OP) nerve agents, such as soman (GD), pose great risk to neurological health by inhibiting acetylcholinesterase, leading to seizures, epilepsy, and behavioral deficits.
Nyzil Massey, Suraj S. Vasanthi, Luis G. Gimenez-Lirola, Harm Tyler, Thimmasettappa Thippeswamy   +4 more
doaj   +2 more sources

Sex‐based structural and functional MRI outcomes in the rat brain after soman (GD) exposure‐induced status epilepticus

Epilepsia Open, 2023
Objective Exposure to the nerve agent, soman (GD), induces status epilepticus (SE), epileptogenesis, and even death. Although rodent models studying the pathophysiological mechanisms show females to be more reactive to soman, no tangible sex differences ...
Meghan Gage, Suraj S Vasanthi, Christina M Meyer, Nikhil S Rao, Daniel R Thedens, Sridhar S. Kannurpatti, Thimmasettappa Thippeswamy   +6 more
doaj   +1 more source