Results 21 to 30 of about 10,817 (281)

Soman (GD) Rat Model to Mimic Civilian Exposure to Nerve Agent: Mortality, Video-EEG Based Status Epilepticus Severity, Sex Differences, Spontaneously Recurring Seizures, and Brain Pathology

Frontiers in Cellular Neuroscience, 2022
Modeling a real-world scenario of organophosphate nerve agent (OPNA) exposure is challenging. Military personnel are premedicated with pyridostigmine, which led to the development of OPNA models with pyridostigmine/oxime pretreatment to investigate novel
Meghan Gage, Meghan Gage, Nikhil S. Rao, Manikandan Samidurai, Marson Putra, Marson Putra, Suraj S. Vasanthi, Christina Meyer, Chong Wang, Thimmasettappa Thippeswamy, Thimmasettappa Thippeswamy   +10 more
doaj   +1 more source

Antiseizure and Neuroprotective Efficacy of Midazolam in Comparison with Tezampanel (LY293558) against Soman-Induced Status Epilepticus

Toxics, 2022
Acute exposure to nerve agents induces status epilepticus (SE), which can cause death or long-term brain damage. Diazepam is approved by the FDA for the treatment of nerve agent-induced SE, and midazolam (MDZ) is currently under consideration to replace ...
Taiza H. Figueiredo, Vassiliki Aroniadou-Anderjaska, Volodymyr I. Pidoplichko, James P. Apland, Maria F. M. Braga   +4 more
doaj   +1 more source

Dataset of EEG power integral, spontaneous recurrent seizure and behavioral responses following combination drug therapy in soman-exposed rats

Data in Brief, 2019
This article investigated the efficacy of the combination of antiepileptic drug therapy in protecting against soman-induced seizure severity, epileptogenesis and performance deficits.
Lucille A. Lumley, Franco Rossetti, Marcio de Araujo Furtado, Brenda Marrero-Rosado, Caroline R. Schultz, Mark K. Schultz, Jerome Niquet, Claude G. Wasterlain   +7 more
doaj   +1 more source

Refractory and Super-Refractory Status Epilepticus in Nerve Agent-Poisoned Rats Following Application of Standard Clinical Treatment Guidelines

Frontiers in Neuroscience, 2021
Nerve agents (NAs) induce a severe cholinergic crisis that can lead to status epilepticus (SE). Current guidelines for treatment of NA-induced SE only include prehospital benzodiazepines, which may not fully resolve this life-threatening condition.
Julia E. Morgan, Sara C. Wilson, Benjamin J. Travis, Kathryn H. Bagri, Kathleen T. Pagarigan, Hannah M. Belski, Cecelia Jackson, Kevin M. Bounader, Jessica M. Coppola, Eden N. Hornung, James E. Johnson, Hilary S. McCarren   +11 more
doaj   +1 more source

The Evaluation of Benefit of Newly Prepared Reversible Inhibitors of Acetylcholinesterase and Commonly Used Pyridostigmine as Pharmacological Pretreatment of Soman-Poisoned Mice

Acta Medica, 2017
Aim: The ability of four newly prepared reversible inhibitors of acetylcholinesterase (6-chlorotacrine, 7-phenoxytacrine, compounds 1 and 2) and currently used carbamate pyridostigmine to increase the resistance of mice against soman and the efficacy of ...
Jiří Kassa, Jan Korábečný, Eugenie Nepovimová   +2 more
doaj   +1 more source

Neuroprotective effects of a catalytic antioxidant in a rat nerve agent model

Redox Biology, 2019
Persistent inhibition of acetylcholinesterase resulting from exposure to nerve agents such as soman, is associated with prolonged seizure activity known as status epilepticus (SE). Without medical countermeasures, exposure to soman and resultant SE leads
Li-Ping Liang, Jennifer N. Pearson-Smith, Jie Huang, Brian J. Day, Manisha Patel   +4 more
doaj   +1 more source

Midazolam protects B35 neuroblastoma cells through Akt-phosphorylation in reactive oxygen species derived cellular injury [PDF]

Korean Journal of Anesthesiology, 2012
BackgroundSoman, a potent irreversible acetylcholinesterase (AChE) inhibitor, induces delayed neuronal injury by reactive oxygen species (ROS). Midazolam is used in patients with pathologic effects of oxidative stresses such as infection, hemodynamic ...
Won Seog Chong, Chang Lim Hyun, Min Kyu Park, Jeong Min Park, Hyun-Ouk Song, Taejin Park, Young Su Lim, Choon Kyu Cho, Po Soon Kang, Hee Uk Kwon   +9 more
doaj   +1 more source

Prophylactic and therapeutic efficacy of the soman-simulator, pinacolyl dimethylphosphinate

, 1986
Atropinized rats, intoxicated with 6 or 8 x LD50 soman and subsequently treated with the oxime HI-6 died several hours after intoxication. Oral or intravenous administration of the soman-simulator, pinacolyl dimethylphosphinate (PDP), given at ...
Wiel, H.J. van der, Helden, H.P.M. van, Wolthuis, O.L.   +2 more
core   +2 more sources

Monitoring Exposure to Five Chemical Warfare Agents Using the Dried Urine Spot Technique and Liquid Chromatography-Mass Spectrometry/Mass Spectrometry—In Vivo Determination of Sarin Metabolite in Mice

Molecules, 2023
Dried urine spot (DUS) is a micro-sample collection technique, known for its advantages in handling, storage and shipping. It also uses only a small volume of urine, an essential consideration in working with small animals, or in acute medical situations.
Lilach Yishai Aviram, Shai Dagan, Ariel Hindi, Shira Chapman, Rellie Gez, Eyal Drug   +5 more
doaj   +1 more source

Neuroprotective Effects of Antidotes in Soman-Poisoned Rats

Acta Medica, 1999
1. The neuroprotective effects of antidotes (atropine, obidoxime/atropine mixture, HI-6/atropine mixture) on rats poisoned with soman at a sublethal dose (48 μg/kg i.m.; 60% of LD50 value) were studied.
Jiří Kassa, Marie Koupilová
doaj   +1 more source