Results 31 to 40 of about 5,197 (259)

The Evaluation of Benefit of Newly Prepared Reversible Inhibitors of Acetylcholinesterase and Commonly Used Pyridostigmine as Pharmacological Pretreatment of Soman-Poisoned Mice

Acta Medica, 2017
Aim: The ability of four newly prepared reversible inhibitors of acetylcholinesterase (6-chlorotacrine, 7-phenoxytacrine, compounds 1 and 2) and currently used carbamate pyridostigmine to increase the resistance of mice against soman and the efficacy of ...
Jiří Kassa, Jan Korábečný, Eugenie Nepovimová   +2 more
doaj   +1 more source

Refractory and Super-Refractory Status Epilepticus in Nerve Agent-Poisoned Rats Following Application of Standard Clinical Treatment Guidelines

Frontiers in Neuroscience, 2021
Nerve agents (NAs) induce a severe cholinergic crisis that can lead to status epilepticus (SE). Current guidelines for treatment of NA-induced SE only include prehospital benzodiazepines, which may not fully resolve this life-threatening condition.
Julia E. Morgan, Sara C. Wilson, Benjamin J. Travis, Kathryn H. Bagri, Kathleen T. Pagarigan, Hannah M. Belski, Cecelia Jackson, Kevin M. Bounader, Jessica M. Coppola, Eden N. Hornung, James E. Johnson, Hilary S. McCarren   +11 more
doaj   +1 more source

Neuroprotective effects of a catalytic antioxidant in a rat nerve agent model

Redox Biology, 2019
Persistent inhibition of acetylcholinesterase resulting from exposure to nerve agents such as soman, is associated with prolonged seizure activity known as status epilepticus (SE). Without medical countermeasures, exposure to soman and resultant SE leads
Li-Ping Liang, Jennifer N. Pearson-Smith, Jie Huang, Brian J. Day, Manisha Patel   +4 more
doaj   +1 more source

Midazolam protects B35 neuroblastoma cells through Akt-phosphorylation in reactive oxygen species derived cellular injury [PDF]

Korean Journal of Anesthesiology, 2012
BackgroundSoman, a potent irreversible acetylcholinesterase (AChE) inhibitor, induces delayed neuronal injury by reactive oxygen species (ROS). Midazolam is used in patients with pathologic effects of oxidative stresses such as infection, hemodynamic ...
Won Seog Chong, Chang Lim Hyun, Min Kyu Park, Jeong Min Park, Hyun-Ouk Song, Taejin Park, Young Su Lim, Choon Kyu Cho, Po Soon Kang, Hee Uk Kwon   +9 more
doaj   +1 more source

Neuroprotective Effects of Antidotes in Soman-Poisoned Rats

Acta Medica, 1999
1. The neuroprotective effects of antidotes (atropine, obidoxime/atropine mixture, HI-6/atropine mixture) on rats poisoned with soman at a sublethal dose (48 μg/kg i.m.; 60% of LD50 value) were studied.
Jiří Kassa, Marie Koupilová
doaj   +1 more source

Monitoring Exposure to Five Chemical Warfare Agents Using the Dried Urine Spot Technique and Liquid Chromatography-Mass Spectrometry/Mass Spectrometry—In Vivo Determination of Sarin Metabolite in Mice

Molecules, 2023
Dried urine spot (DUS) is a micro-sample collection technique, known for its advantages in handling, storage and shipping. It also uses only a small volume of urine, an essential consideration in working with small animals, or in acute medical situations.
Lilach Yishai Aviram, Shai Dagan, Ariel Hindi, Shira Chapman, Rellie Gez, Eyal Drug   +5 more
doaj   +1 more source

Assessment of the Therapeutic and Anticonvulsive Efficacy of a Drug Combination Consisting of Trihexyphenidyle and HI-6 in Soman-Poisoned Rats

Acta Medica, 2004
1. The influence of two anticholinergic drugs (atropine, trihexyphenidyle) on the effectiveness of antidotal treatment to eliminate soman-induced lethal effects and convulsions was studied in rats. 2.
Jiří Kassa, Ivan Samnaliev
doaj   +1 more source

Assessing the Clinical Features and Blood Biochemistries of Acute Organophosphorus Chemical Warfare Agents in Iranian Veterans

International Journal of Medical Toxicology and Forensic Medicine, 2021
Background: Nerve Agents (NAs) are a chemical weapons, and their use is prohibited. They were used for numerous-times in the warfare of Iraq against Iran.
khosrow Agin , Babak Mostafazadeh
doaj   +1 more source

The Influence of Anticholinergic Drug Selection on the Effectiveness of Oximes Against Soman-Induced Supralethal Poisoning in Mice

Acta Medica, 2001
1. The influence of anticholinergic drugs (atropine, benactyzine, biperiden) on the efficacy of monopyridinium and bispyridinium oximes (HI-6, BI-6, obidoxime, pralidoxime, methoxime) on soman-induced supralethal poisoning was studied in mice. 2.
Jiří Kassa
doaj   +1 more source

Antimicrobial Activity and Degradation Ability Study on Nanoparticle-Enriched Formulations Specially Designed for the Neutralization of Real and Simulated Biological and Chemical Warfare Agents

Pharmaceuticals, 2022
The present work reveals a comprehensive decontamination study on real and simulated biological and chemical warfare agents (BCWA). The emphasis was on evaluating the antimicrobial activity against real biological warfare agents, such as Bacillus ...
Raluca-Elena Ginghina, Gabriela Toader, Munizer Purica, Adriana-Elena Bratu, Claudiu Lazaroaie, Tudor-Viorel Tiganescu, Ramona-Elena Oncioiu, George-Ovidiu Iorga, Florina-Lucica Zorila, Mihai Constantin, Gabriel Craciun, Florin Comanescu, Cosmin Romanitan   +12 more
doaj   +1 more source