(-)-Phenserine attenuates soman-induced neuropathology. [PDF]
PLoS ONE, 2014 Organophosphorus (OP) nerve agents are deadly chemical weapons that pose an alarming threat to military and civilian populations. The irreversible inhibition of the critical cholinergic degradative enzyme acetylcholinesterase (AChE) by OP nerve agents ...
Jun Chen +11 more
doaj +4 more sources
Mitigating organophosphate nerve agent, soman (GD), induced long-term neurotoxicity: Saracatinib, a Src Tyrosine Kinase inhibitor, as a potential countermeasure [PDF]
Journal of NeuroinflammationBackground Acute exposure to soman (GD), an organophosphate nerve agent (OPNA), irreversibly inhibits acetylcholinesterase (AChE), induces seizures, and could be fatal if not treated immediately.
Nyzil Massey +10 more
doaj +2 more sources
Proteomics Reveals Mechanisms of Metabolic Dysregulation in Soman Neurotoxicity [PDF]
ToxicsSoman, an organophosphorus nerve agent, induces neurotoxicity primarily by inhibiting acetylcholinesterase, triggering a series of pathological events including cholinergic crisis, seizures, calcium overload, oxidative stress, mitochondrial dysfunction ...
Xing-Xing Zong +6 more
doaj +2 more sources
Anticonvulsants for Soman-Induced Seizure Activity
Journal of Biomedical Science, 1999 This report describes studies of anticonvulsants for the organophosphorus (OP) nerve agent soman: a basic research effort to understand how different pharmacological classes of compounds influence the expression of seizure produced by soman in rats, and a drug screening effort to determine whether clinically useful antiepileptics can modulate soman ...
John H McDonough +2 more
exaly +3 more sources
Ultra-Sensitive Analysis of Organophosphorus Compounds by Comparative GC-FPD and GC-ICP-MS: Implications for Chemical Warfare Agent Detection [PDF]
MoleculesOrganophosphorus chemical warfare agents such as sarin (GB), soman (GD), and cyclosarin (GF) rank among the most toxic substances known, making trace-level detection critical for public and military safety.
Michał Wiktorko +5 more
doaj +2 more sources
A wrench in the works of human acetylcholinesterase: soman induced conformational changes revealed by molecular dynamics simulations. [PDF]
PLoS ONE, 2015 Irreversible inactivation of human acetylcholinesterase (hAChE) by organophosphorous pesticides (OPs) and chemical weapon agents (CWA) has severe morbidity and mortality consequences. We present data from quantum mechanics/molecular mechanics (QM/MM) and
Brian J Bennion +5 more
doaj +1 more source
Epilepsia Open, 2023 Objective Exposure to the nerve agent, soman (GD), induces status epilepticus (SE), epileptogenesis, and even death. Although rodent models studying the pathophysiological mechanisms show females to be more reactive to soman, no tangible sex differences ...
Meghan Gage +6 more
doaj +1 more source
Clinical Infectious Diseases, 2013 A reply to Soman R, Gupta N, Shetty A, Rodrigues C. Are prolonged/continuous infusions of β-lactams for all? Clin Infect Dis 2013;57:323.
Dulhunty, Joel M. +10 more
openaire +5 more sources
Antidotal effect of combinations obidoxime/HI-6 and memantine in mice poisoned with soman, dichlorvos or heptenophos [PDF]
Vojnosanitetski Pregled, 2011 Introduction/Aim. In acute organophosphate poisoning the issue of special concern is the appearance of muscle fasciculations and convulsions that cannot be adequately antagonised by the use of atropine and oxime therapy.
Antonijević Biljana +3 more
doaj +1 more source
Acta Medica, 2003 1. To study the influence of pharmacological pretreatment (PANPAL or pyridostigmine combined with biperiden) and antidotal treatment (the oxime HI-6 plus atropine) on soman-induced neurotoxicity, male albino rats were poisoned with a lethal dose of soman
Jiří Kassa +2 more
doaj +1 more source