Results 11 to 20 of about 9,449 (276)
, 2016 Soman (O-pinacolyl methylphosphonofluoridate) is a potent neurotoxicant. Acute exposure to soman causes acetylcholinesterase inhibition, resulting in excessive levels of acetylcholine.
Robert K. Kan (2379820) +5 more
core +24 more sources
Clinical Infectious Diseases, 2013 A reply to Soman R, Gupta N, Shetty A, Rodrigues C. Are prolonged/continuous infusions of β-lactams for all? Clin Infect Dis 2013;57:323.
Dulhunty, Joel M. +10 more
openaire +6 more sources
Acta Medica, 2003 1. To study the influence of pharmacological pretreatment (PANPAL or pyridostigmine combined with biperiden) and antidotal treatment (the oxime HI-6 plus atropine) on soman-induced neurotoxicity, male albino rats were poisoned with a lethal dose of soman
Jiří Kassa +2 more
doaj +2 more sources
Inhalation Apparatus for Generating Sarin and Soman Toxic Vapors
Acta Medica, 2003 The developed inhalation system is a dynamic and whole-body exposure model designated for generating sarin or soman vapors. It consists of an evaporating apparatus, an inhalation chamber and a carbon filter.
Lucie Ševelová +2 more
doaj +2 more sources
A wrench in the works of human acetylcholinesterase: soman induced conformational changes revealed by molecular dynamics simulations. [PDF]
PLoS ONE, 2015 Irreversible inactivation of human acetylcholinesterase (hAChE) by organophosphorous pesticides (OPs) and chemical weapon agents (CWA) has severe morbidity and mortality consequences. We present data from quantum mechanics/molecular mechanics (QM/MM) and
Brian J Bennion +5 more
doaj +1 more source
Antidotal effect of combinations obidoxime/HI-6 and memantine in mice poisoned with soman, dichlorvos or heptenophos [PDF]
Vojnosanitetski Pregled, 2011 Introduction/Aim. In acute organophosphate poisoning the issue of special concern is the appearance of muscle fasciculations and convulsions that cannot be adequately antagonised by the use of atropine and oxime therapy.
Antonijević Biljana +3 more
doaj +1 more source
The Influence of Oxime Selection on the Efficacy of Antidotal Treatment of Soman-Poisoned Rats
Acta Medica, 2002 1. The influence of some acetylcholinesterase reactivators (HI-6, obidoxime, pralidoxime) on the efficacy of antidotal treatment to eliminate soman-induced disturbance of respiration and circulation and to protect experimental animals poisoned with ...
Jiří Kassa, Josef Fusek
doaj +1 more source
ADMET and Druglikeness Calculations of Sarin, Soman, and Their Hypothetical Derivatives
Iraqi Journal of Industrial Research, 2022 Absorption, Distribution, Metabolism, Excretion, and Toxicity (ADMET) represents a numerical classification of any chemical to be a drug candidate with promising therapeutic efficacy with minimum toxicity or sensitivity depending on its chemical ...
Kafa Khalaf Hammud
doaj +1 more source
Dose Dependent Prophylactic Efficacy of 6-Chlorotacrine in Soman-Poisoned Mice
Acta Medica, 2018 Aim: The influence of the dose on the ability of promising newly prepared reversible inhibitor of acetylcholinesterase (6-chlorotacrine) to increase the resistance of mice against soman and the efficacy of antidotal treatment of soman-poisoned mice was ...
Jiří Kassa, Jan Korábečný
doaj +1 more source
Epilepsia Open, 2023 Despite new antiseizure medications, the development of cholinergic‐induced refractory status epilepticus (RSE) continues to be a therapeutic challenge as pharmacoresistance to benzodiazepines and other antiseizure medications quickly develops.
Jerome Niquet +3 more
doaj +1 more source