Results 11 to 20 of about 10,817 (281)

(-)-Phenserine attenuates soman-induced neuropathology. [PDF]

PLoS ONE, 2014
Organophosphorus (OP) nerve agents are deadly chemical weapons that pose an alarming threat to military and civilian populations. The irreversible inhibition of the critical cholinergic degradative enzyme acetylcholinesterase (AChE) by OP nerve agents ...
Jun Chen, Hongna Pan, Cynthia Chen, Wei Wu, Kevin Iskandar, Jeffrey He, Tetsade Piermartiri, David M Jacobowitz, Qian-Sheng Yu, John H McDonough, Nigel H Greig, Ann M Marini   +11 more
doaj   +5 more sources

Reply to Soman et al [PDF]

Clinical Infectious Diseases, 2013
A reply to Soman R, Gupta N, Shetty A, Rodrigues C. Are prolonged/continuous infusions of β-lactams for all? Clin Infect Dis 2013;57:323.
Dulhunty, Joel M., Roberts, Jason A., Davis, Joshua S., Webb, Steven A. R., Bellomo, Rinaldo, Gomersall, Charles, Shirwadkar, Charudatt, Eastwood, Glenn M., Myburgh, John, Paterson, David L., Lipman, Jeffrey   +10 more
openaire   +6 more sources

Gene Expression Profiling of Rat Hippocampus Following Exposure to the Acetylcholinesterase Inhibitor Soman

, 2016
Soman (O-pinacolyl methylphosphonofluoridate) is a potent neurotoxicant. Acute exposure to soman causes acetylcholinesterase inhibition, resulting in excessive levels of acetylcholine.
Robert K. Kan (2379820), Christina P. Tompkins (2379829), Denise M. Kniffin (2379823), Christopher S. Phillips (2379826), Tracey A. Hamilton (66920), James F. Dillman (2324800)   +5 more
core   +17 more sources

Inhalation Apparatus for Generating Sarin and Soman Toxic Vapors

Acta Medica, 2003
The developed inhalation system is a dynamic and whole-body exposure model designated for generating sarin or soman vapors. It consists of an evaporating apparatus, an inhalation chamber and a carbon filter.
Lucie Ševelová, Josef Vachek, Jiří Bajgar   +2 more
doaj   +2 more sources

Toxicokinetics of the four stereoisomers of the nerve agent soman in atropinized rats—Influence of a soman simulator

Toxicology and Applied Pharmacology, 1987
The toxicokinetics of the four stereoisomers of C(+/-)P(+/-)-soman were investigated in anesthetized, atropinized, and artificially ventilated rats at iv doses of 6 (495 micrograms/kg) and 3 LD50. By integration of a thermodesorption/cold trap injector into our GLC analysis, the soman stereoisomers could be followed in rat blood down to a minimum ...
Benschop, H.P., Bijleveld, E.C., Jong, L.P.A. de, Wiel, H.J. van der, Helden, H.P.M. van   +4 more
openaire   +4 more sources

Inhalation Toxicokinetics of Soman Stereoisomers in the Atropinized Guinea Pig with Nose-Only Exposure to Soman Vapor

Toxicology and Applied Pharmacology, 1998
The toxicokinetics of the four stereoisomers of the nerve agent C(+/-)P(+/-)-soman were studied in anesthetized, atropinized guinea pigs for nose-only exposure to soman vapor. During exposure the respiratory minute volume (RMV) and respiratory frequency (RF) were monitored.
Langenberg, J.P., Spruit, W.E.T., Wiel, H.J. van der, Trap, H.C., Helmich, R.B., Bergers, W.W.A., Helden, H.P.M. van, Benschop, H.P.   +7 more
openaire   +4 more sources

Dose Dependent Prophylactic Efficacy of 6-Chlorotacrine in Soman-Poisoned Mice

Acta Medica, 2018
Aim: The influence of the dose on the ability of promising newly prepared reversible inhibitor of acetylcholinesterase (6-chlorotacrine) to increase the resistance of mice against soman and the efficacy of antidotal treatment of soman-poisoned mice was ...
Jiří Kassa, Jan Korábečný
doaj   +1 more source

Polyclonal Antibody to Soman-Tyrosine [PDF]

Chemical Research in Toxicology, 2013
Soman forms a stable, covalent bond with tyrosine 411 of human albumin, with tyrosines 257 and 593 in human transferrin, and with tyrosine in many other proteins. The pinacolyl group of soman is retained, suggesting that pinacolyl methylphosphonate bound to tyrosine could generate specific antibodies.
Bin, Li, Ellen G, Duysen, Marie-Thérèse, Froment, Patrick, Masson, Florian, Nachon, Wei, Jiang, Lawrence M, Schopfer, Geoffrey M, Thiele, Lynell W, Klassen, John, Cashman, Gareth R, Williams, Oksana, Lockridge   +11 more
openaire   +2 more sources

Changes of Cholinesterase Activity in the Erythrocytes, Plasma, Diaphragm, Liver and Various Parts of the Brain in the Rabbit Following Transfusion of Erythrocytes with Soman Inhibited Acetylcholinesterase

Acta Medica, 1997
1. The changes of cholinesterase activity in rabbit blood, peripheral tissues and the central nervous system following transfusion of erythrocytes with soman inhibited acetylcholinesterase were demonstrated. 2. After incubation with soman for 0.5 or 24 h,
Jiří Kassa, Jiří Bajgar, Josef Fusek
doaj   +1 more source

Treatment of cholinergic‐induced status epilepticus with polytherapy targeting GABA and glutamate receptors

Epilepsia Open, 2023
Despite new antiseizure medications, the development of cholinergic‐induced refractory status epilepticus (RSE) continues to be a therapeutic challenge as pharmacoresistance to benzodiazepines and other antiseizure medications quickly develops.
Jerome Niquet, Donna Nguyen, Marcio deAraujo Furtado, Lucille Lumley   +3 more
doaj   +1 more source