Results 1 to 10 of about 258,722 (267)
HI-6-loaded PEGylated liposomes: an on-site first-aid strategy for acute organophosphorus agent poisoning [PDF]
Drug Delivery, 2023 Organophosphorus agents, also known as nerve agents, are very dangerous chemicals that were used as chemical warfare agents. HI-6 is one of the most promising reactivators which is effective in reactivating AChE inhibited by many nerve agents.
Liao Shen +5 more
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Association between hydrogen gas inhalation and cardiac output in an asphyxiated piglet model [PDF]
Scientific ReportsAbout 80% of neonates with hypoxic-ischaemic encephalopathy (HIE) have cardiovascular dysfunction and are vulnerable to late-onset injury due to disrupted cerebral blood flow and metabolism.
Kosuke Sakamoto +15 more
doaj +2 more sources
Neurobiology of Disease, 2021 The result of a deprivation of oxygen and glucose to the brain, hypoxic–ischemic encephalopathy (HIE), remains the most common cause of death and disability in human neonates globally and is mediated by glutamate toxicity and inflammation.
O. Arteaga Cabeza +9 more
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Protective effect of HI-6 and trimedoxime combination in mice acutely poisoned with tabun, dichlorvos or heptenophos [PDF]
Acta Veterinaria, 2012 The aim of this study was to compare the protective effect of two individual oximes (HI-6 and trimedoxime) with their combination in mice acutely poisoned with tabun, dichlorvos or heptenophos.
Antonijević Biljana +2 more
doaj +1 more source
Ibrain, 2022 This study aimed to investigate the role of interleukin‐6 (IL‐6) in the pathogenesis of neonatal hypoxic‐ischemic encephalopathy (NHIE). Sprague‐Dawley (SD) rats were used for the establishment of hypoxic‐ischemic (HI) model.
Xiu Yang +3 more
doaj +1 more source
Acta Medica, 2010 The studies dealing with mechanism of organophosphates (OP)/nerve agent action, prophylaxis and treatment of intoxications is a very hot topic at present.
Jiří Bajgar
doaj +1 more source
Nanoparticulate transport of oximes over an in vitro blood-brain barrier model [PDF]
, 2010 Background: Due to the use of organophosphates (OP) as pesticides and the availability of OP-type nerve agents, an effective medical treatment for OP poisonings is still a challenging problem.
Wagner, Sylvia +9 more
core +2 more sources
Dose Dependent Prophylactic Efficacy of 6-Chlorotacrine in Soman-Poisoned Mice
Acta Medica, 2018 Aim: The influence of the dose on the ability of promising newly prepared reversible inhibitor of acetylcholinesterase (6-chlorotacrine) to increase the resistance of mice against soman and the efficacy of antidotal treatment of soman-poisoned mice was ...
Jiří Kassa, Jan Korábečný
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The Alpha 7 Nicotinic Acetylcholine Receptor Does Not Affect Neonatal Brain Injury
Biomedicines, 2022 Inflammation plays a central role in the development of neonatal brain injury. The alpha 7 nicotinic acetylcholine receptor (α7nAChR) can modulate inflammation and has shown promising results as a treatment target in rodent models of adult brain injury ...
Maria E. Hammarlund +10 more
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Hydronephrosis Index as a New Method for the Evaluation and Follow-up of Fetal Hydronephrosis [PDF]
Iranian Journal of Neonatology, 2020 Background: The present study was conducted to compare the efficiency of hydronephrosis index (HI) with those of pelvic anteroposterior (AP) diameter and parenchymal thickness in the diagnosis of fetal hydronephrosis in the prenatal period, as well as 1,
Farideh Gharekhanloo
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