Results 1 to 10 of about 10,038,951 (181)
HI-6-loaded PEGylated liposomes: an on-site first-aid strategy for acute organophosphorus agent poisoning [PDF]
Drug Delivery, 2023 Organophosphorus agents, also known as nerve agents, are very dangerous chemicals that were used as chemical warfare agents. HI-6 is one of the most promising reactivators which is effective in reactivating AChE inhibited by many nerve agents.
Liao Shen +5 more
doaj +3 more sources
Molecular Modeling Study of Uncharged Oximes Compared to HI-6 and 2-PAM Inside Human AChE Sarin and VX Conjugates. [PDF]
ACS Omega, 2020 The deleterious effects of nerve agents over the enzymes acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) turned these compounds into the most dangerous chemical weapons known.
Souza FR +6 more
europepmc +2 more sources
HI-6 assisted catalytic scavenging of VX by acetylcholinesterase choline binding site mutants. [PDF]
Chem Biol Interact, 2016 The high toxicity of organophosphorus compounds originates from covalent inhibition of acetylcholinesterase (AChE), an essential enzyme in cholinergic neurotransmission.
Maček Hrvat N +4 more
europepmc +2 more sources
Structure of a prereaction complex between the nerve agent sarin, its biological target acetylcholinesterase, and the antidote HI-6. [PDF]
Proc Natl Acad Sci U S A, 2016 Allgardsson A +6 more
europepmc +2 more sources
European Journal of Pharmaceutical Sciences, 2023 PURPOSE Organophosphorus compounds (OPs) is a serious threat to human health and life safety, but because of the existence of blood-brain barrier, most of the therapeutic drugs can not enter the center, reactivate centrally located toxic ...
Ning Fan +5 more
semanticscholar +1 more source
Neurobiology of Disease, 2021 The result of a deprivation of oxygen and glucose to the brain, hypoxic–ischemic encephalopathy (HIE), remains the most common cause of death and disability in human neonates globally and is mediated by glutamate toxicity and inflammation.
O. Arteaga Cabeza +9 more
doaj +1 more source
Evaluation of the neuroprotective efficacy of individual oxime (HI-6) and oxime mixtures (HI-6 + trimedoxime, HI-6 + K203) in tabun-poisoned rats [PDF]
Journal of Applied Biomedicine, 2009 The ability of the oxime HI-6 to reduce tabun-induced acute neurotoxic signs and symptoms was compared with the neuroprotective efficacy of two combinations of oximes (HI-6 + trimedoxime, HI-6 + K203) using a functional observational battery. Tabun-induced neurotoxicity and the neuroprotective effects of HI-6 alone, and HI-6 combined with trimedoxime ...
Jiří Kassa +2 more
openaire +1 more source
Protective effect of HI-6 and trimedoxime combination in mice acutely poisoned with tabun, dichlorvos or heptenophos [PDF]
Acta Veterinaria, 2012 The aim of this study was to compare the protective effect of two individual oximes (HI-6 and trimedoxime) with their combination in mice acutely poisoned with tabun, dichlorvos or heptenophos.
Antonijević Biljana +2 more
doaj +1 more source
Drug Testing and Analysis, 2020 Oximes like pralidoxime (2-PAM), obidoxime (Obi) and HI-6 are the only currently available therapeutics to reactivate inhibited acetylcholinesterase (AChE) in case of intoxications with organophosphorus (OP) compounds.
T. Kranawetvogl +3 more
semanticscholar +1 more source
Ibrain, 2022 This study aimed to investigate the role of interleukin‐6 (IL‐6) in the pathogenesis of neonatal hypoxic‐ischemic encephalopathy (NHIE). Sprague‐Dawley (SD) rats were used for the establishment of hypoxic‐ischemic (HI) model.
Xiu Yang +3 more
doaj +1 more source