Results 11 to 20 of about 258,722 (267)
Evaluation of the neuroprotective efficacy of individual oxime (HI-6) and oxime mixtures (HI-6 + trimedoxime, HI-6 + K203) in tabun-poisoned rats [PDF]
Journal of Applied Biomedicine, 2009 The ability of the oxime HI-6 to reduce tabun-induced acute neurotoxic signs and symptoms was compared with the neuroprotective efficacy of two combinations of oximes (HI-6 + trimedoxime, HI-6 + K203) using a functional observational battery. Tabun-induced neurotoxicity and the neuroprotective effects of HI-6 alone, and HI-6 combined with trimedoxime ...
Jiří Kassa +2 more
openaire +1 more source
HI-6 assisted catalytic scavenging of VX by acetylcholinesterase choline binding site mutants. [PDF]
Chem Biol Interact, 2016 The high toxicity of organophosphorus compounds originates from covalent inhibition of acetylcholinesterase (AChE), an essential enzyme in cholinergic neurotransmission. Poisonings that lead to life-threatening toxic manifestations require immediate treatment that combines administration of anticholinergic drugs and an aldoxime as a reactivator of AChE.
Maček Hrvat N +4 more
europepmc +7 more sources
Sulfur mustard induced oxidative stress and its alteration using asoxime (HI-6). [PDF]
Interdiscip Toxicol, 2013 ABSTRACT Sulfur mustard (SM) is a blister agent with cytotoxic mechanism of action. There is no suitable treatment based on administration of an antidote. In this study, Wistar rats were exposed to SM in doses of 0-40 mg/kg body weight and treated with the compound HI-6.
Pohanka M +3 more
europepmc +4 more sources
High spatial resolution mid-infrared observations of the low-mass young star TW Hya [PDF]
, 2007 We want to improve knowledge of the structure of the inner few AU of the circumstellar disk around the nearby T Tauri star TW Hya. Earlier studies have suggested the existence of a large inner hole, possibly caused by interactions with a growing ...
Bouwman, J. +5 more
core +4 more sources
BMC Pharmacology and Toxicology, 2018 Background The aim of our study was to compare the ability of two combinations of oximes (HI-6 + trimedoxime and HI-6 + K203) with atropine to counteract acute sarin-induced brain damage with the efficacy of antidotal treatment involving single oxime (HI-
Filip Caisberger +5 more
doaj +1 more source
Frontiers in Cellular Neuroscience, 2021 Inflammation and neonatal hypoxia-ischemia (HI) are important etiological factors of perinatal brain injury. However, underlying mechanisms remain unclear.
Gagandeep Singh-Mallah +11 more
doaj +1 more source
Acta Medica, 2008 The protective effect of the reversible cholinesterase inhibitors tacrine and pyridostigmine alone or in combination with different drugs against acetylcholinesterase inhibition in the pontomedullar area and cerebellum of rats caused by VX agent (O-ethyl
Jiří Bajgar
doaj +1 more source
Serological response of patients with influenza A (H1N1) pdm09-associated pneumonia: an observational study. [PDF]
PLoS ONE, 2013 BACKGROUND: Little is known about the dynamics or magnitude of antibody response in patients with influenza A (H1N1) pdm09-associated pneumonia. We described and compared the antibody response to influenza A (H1N1) pdm09 in patients with and without ...
Nasikarn Angkasekwinai +7 more
doaj +1 more source
Intranasal administration of human MSC for ischemic brain injury in the mouse: in vitro and in vivo neuroregenerative functions. [PDF]
PLoS ONE, 2014 Intranasal treatment with C57BL/6 MSCs reduces lesion volume and improves motor and cognitive behavior in the neonatal hypoxic-ischemic (HI) mouse model.
Vanessa Donega +6 more
doaj +1 more source
Acta Medica, 2012 The reactivating and therapeutic efficacy of two combinations of oximes (HI‑6 + trimedoxime and HI‑6 + K203) was compared with the effectiveness of antidotal treatment involving single oxime (HI‑6, trimedoxime, K203) using in vivo methods.
Jiří Kassa +4 more
doaj +1 more source