Results 1 to 10 of about 1,056 (182)

In Vitro Reactivation of Acetylcholinesterase Inhibited by Cyclosarin Using Bisquaternary Pyridinium Aldoximes K005, K033, K027 and K048 [PDF]

Acta Medica, 2004
We have tested four new bisquaternary pyridinium acetylcholinesterase (AChE; EC 3.1.1.7) reactivators – K005 (1,3–bis(2–hydroxyiminomethylpyridinium) propane dibromide), K033 (1,4–bis(2–hydroxyiminomethylpyridinium) butane dibromide), K027 (1–(4 ...
Kamil Kuča, Lucie Ševelová-Bartošová, Gabriela Krejčová-Kunešová   +2 more
doaj   +3 more sources

Repeated low-dose organophosphate DFP exposure leads to the development of depression and cognitive impairment in a rat model of Gulf War Illness [PDF]

, 2016
Approximately 175,000 to 250,000 of the returning veterans from the 1991 Persian Gulf War exhibit chronic multi-symptom illnesses that includes neurologic co-morbidities such as depression, anxiety and cognitive impairments.
Deshpande, Laxmikant, Phillips, Kristin
core   +2 more sources

The Ability of Oxime Mixtures to Increase the Reactivating and Therapeutic Efficacy of Antidotal Treatment of Cyclosarin Poisoning in Rats and Mice

Acta Medica, 2012
The reactivating and therapeutic efficacy of two combinations of oximes (HI‑6 + trimedoxime and HI‑6 + K203) was compared with the effectiveness of antidotal treatment involving single oxime (HI‑6, trimedoxime, K203) using in vivo methods.
Jiří Kassa, Jana Zdarová Karasová, Růžena Pavlíková, Filip Caisberger, Jiří Bajgar   +4 more
doaj   +1 more source

A Comparison of the Potency of the Oxime HLö-7 and Currently Used Oximes (HI-6, Pralidoxime, Obidoxime) to Reactivate Nerve Agent-Inhibited Rat Brain Acetylcholinesterase by in vitro Methods

Acta Medica, 2005
1. The efficacy of the oxime HLö-7 and currently used oximes (pralidoxime, obidoxime, HI-6) to reactivate acetylcholinesterase inhibited by various nerve agents (sarin, tabun, cyclosarin, VX) was tested by in vitro methods. 2. Both H oximes (HLö-7, HI-6)
Kamil Kuča, Jiří Cabal, Jiří Kassa, Daniel Jun, Martina Hrabinová   +4 more
doaj   +1 more source

Chemical Weapons in the Iran-Iraq War (1980–1988). 4. The Destruction of Iraqi Chemical Weapons

Вестник войск РХБ защиты, 2020
After the defeat of Iraqi army in Kuwait in February 1991, on April 3, the UN Security Council (UN Security Council) adopted Resolution 687, that «decides that Iraq shall unconditionally accept the destruction, removal, or rendering harmless, under ...
M. V. Supotnitskiy, N. I. Shilo, V. A. Kovtun   +2 more
doaj   +1 more source

Central Executive Dysfunction and Deferred Prefrontal Processing in Veterans with Gulf War Illness. [PDF]

, 2013
Gulf War Illness is associated with toxic exposure to cholinergic disruptive chemicals. The cholinergic system has been shown to mediate the central executive of working memory (WM).
Bennett, Ilana J, Brigante, Ryan M, Haley, Robert W, Hubbard, Nicholas A, Hutchison, Joanna L, Motes, Michael A, Rypma, Bart, Shokri-Kojori, Ehsan   +7 more
core   +2 more sources

1,3–Bis(2–hydroxyiminomethylpyridinium) Propane as the Potential Reactivator of the Acetylcholinesterase Inhibited by Nerve Agents

Acta Medica, 2004
The oxime K005 [1,3–bis(2–hydroxyiminomethylpyridinium) propane dibromide] for the reactivation of the enzyme acetylcholinesterase (AChE) inhibited by cyclosarin and VX was tested.
Kamil Kuča, Vlastimil Dohnal
doaj   +1 more source

Synthesis of Deuterated Methylphosphonic Acid Derivatives for Use as Standard Compounds in the Analysis of Toxic Chemicals

Вестник войск РХБ защиты, 2021
One of the ways to ensure high reliability of detection, identification and accuracy of quantitative determination of toxic chemicals (TC) in environmental and biomedical samples by gas and liquid chromatography-mass spectrometry methods is to use ...
V. А. Yashkir, V. I. Krylov, I. I. Krylov, A. V. Brown, D. V. Oreshkin, I. V. Rybalchenko, V. N. Fateenkov   +6 more
doaj   +1 more source

Biosilica-nanogold composite: Easy-to-prepare catalyst for soman degradation [PDF]

, 2019
A very fast single-step biosynthesis of gold nanoparticles (AuNPs) using algal cells of Mallomonas kalinae (MK) is introduced. The average particle size of crystalline AuNPs was approximately 10 nm.
Holišová, Veronika, Kolenčík, Marek, Kratošová, Gabriela, Němcová, Yvonne, Peikertová, Pavlína, Schröfel, Adam, Slabotinský, Jiří, Urban, Martin   +7 more
core   +1 more source

Nerve agent hydrolysis activity designed into a human drug metabolism enzyme. [PDF]

PLoS ONE, 2011
Organophosphorus (OP) nerve agents are potent suicide inhibitors of the essential neurotransmitter-regulating enzyme acetylcholinesterase. Due to their acute toxicity, there is significant interest in developing effective countermeasures to OP poisoning.
Andrew C Hemmert, Tamara C Otto, Roberto A Chica, Monika Wierdl, Jonathan S Edwards, Steven M Lewis, Carol C Edwards, Lyudmila Tsurkan, C Linn Cadieux, Shane A Kasten, John R Cashman, Stephen L Mayo, Philip M Potter, Douglas M Cerasoli, Matthew R Redinbo   +14 more
doaj   +1 more source