Results 1 to 10 of about 687 (168)

Effect of Seven Newly Synthesized and Currently Available Oxime Cholinesterase Reactivators on Cyclosarin-Intoxicated Rats [PDF]

International Journal of Molecular Sciences, 2009
Seven new oxime-based acetylcholinesterase reactivators were compared with three currently available ones (obidoxime, trimedoxime, HI-6) for their ability to lessen cholinesterase inhibition in blood and brain of cyclosarin-treated rats. Oximes were given at doses of 5% their LD50 along with 21 mg/kg atropine five min before the LD50 of cyclosarin (120
Miroslav Pohanka, Kamil Kuča, Ladislav Novotný   +2 more
exaly   +4 more sources

Direct reaction of oximes with crotylsarin, cyclosarin, or VX in vitro [PDF]

Archives of Toxicology, 2006
The direct reaction of seven pyridinium oximes with the organophosphorus compounds (OPCs) crotylsarin, cyclosarin, and VX was studied by spectrophotometry. This method allows to quantify different parameters: (a) the half-life times (t (1/2)) of the oxime-OPC reactions on the basis of the changes in the absorption at the zwitterion (betaine) peak ...
Franz Worek, L Szinicz
exaly   +3 more sources

Stereospecificity in the enzymatic hydrolysis of cyclosarin (GF)

Enzyme and Microbial Technology, 2005
Abstract Enzymatic catalysis is one means of accelerating the rate of hydrolysis of G-type organophosphorus nerve agents. Here, the stereospecificity of the catalysis of cyclosarin (GF, O -cyclohexyl methylphosphonofluoridate) hydrolysis by several enzymes was investigated.
Steve Harvey, Frank M Raushel, Tu-Chen Cheng   +2 more
exaly   +2 more sources

Comparison of sarin and cyclosarin toxicity by subcutaneous, intravenous and inhalation exposure in Gottingen minipigs

Inhalation Toxicology, 2014
Sexually mature male and female Gottingen minipigs were exposed to various concentrations of GB and GF vapor via whole-body inhalation exposures or to liquid GB or GF via intravenous or subcutaneous injections. Vapor inhalation exposures were for 10, 60 or 180 min.
Douglas R Sommerville, Pe, William T Muse   +1 more
exaly   +3 more sources

Potency of Five Structurally Different Acetylcholinesterase Reactivators to Reactivate Human Brain Cholinesterases Inhibited by Cyclosarin

Clinical Toxicology, 2007
Acetylcholinesterase (AChE; EC 3.1.1.7) reactivators are used as a part of the antidotal therapy of organophosphorus pesticide and nerve agent intoxications. Cyclosarin is one member of the nerve agent family. In this article, we compared the reactivation potency of five structurally different AChE reactivators (pralidoxime, trimedoxime, methoxime, HS ...
Kamil Kuča, Daniel Jun, Martina Hrabinová   +2 more
exaly   +3 more sources

Quantitative magnetic resonance brain imaging in US army veterans of the 1991 Gulf War potentially exposed to sarin and cyclosarin

NeuroToxicology, 2007
Kristin J Heaton, Roberta F White, Deborah A Yurgelun-Todd   +2 more
exaly  

Cyclosarin nerve agent interaction with the pristine, Stone Wales defected, and Si-doped BN nanosheets: Theoretical study

Physica E: Low-Dimensional Systems and Nanostructures, 2017
Esmail Vessally, Ahmadreza Bekhradnia, A Hosseinian   +2 more
exaly  

A Density functional theory study of the sensitivity of two-dimensional BN nanosheet to nerve agents cyclosarin and tabun

Thin Solid Films, 2017
ladan Edjlali, Esmail Vessally, Ahmadreza Bekhradnia   +2 more
exaly  

In vitro reactivation potency of some acetylcholinesterase reactivators against sarin- and cyclosarin-induced inhibitions

Journal of Applied Toxicology, 2005
Kamil Kuča, Daniel Jun, Jiri Kassa
exaly  

A comparison of reactivating and therapeutic efficacy of newly-developed oximes (K156, K203) and commonly used oximes (obidoxime, HI-6) in cyclosarin-poisoned rats and mice

Toxicology Mechanisms and Methods, 2009
Kamil Kuča, Jiri Kassa, Kamil Musílek
exaly