Cholesterol Oxime Olesoxime Assessed as a Potential Ligand of Human Cholinesterases [PDF]
BiomoleculesOlesoxime, a cholesterol derivative with an oxime group, possesses the ability to cross the blood–brain barrier, and has demonstrated excellent safety and tolerability properties in clinical research.
Dora Kolić +6 more
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Cyclosarin-An Organophosphate Nerve Agent [PDF]
Defence Science Journal, 2005 Organophosphorus compounds ascribed to as nerve agents (sarin, soman, tabun, cyclosarin) are highly toxic, and are considered to be the most dangerous chemical compounds.
Krejcova, G., Kuca, K., Sevelova, L.
core +3 more sources
New Heterostilbene and Triazole Oximes as Potential CNS-Active and Cholinesterase-Targeted Therapeutics [PDF]
BiomoleculesNew furan, thiophene, and triazole oximes were synthesized through several-step reaction paths to investigate their potential for the development of central nervous systems (CNS)-active and cholinesterase-targeted therapeutics in organophosphorus ...
Milena Mlakić +4 more
doaj +2 more sources
Benzyl trichloroacetimidates as derivatizing agents for phosphonic acids related to nerve agents by EI-GC-MS during OPCW proficiency test scenarios [PDF]
Scientific Reports, 2022 The use of benzyl trichloroacetimidates for the benzylation of phosphonic acid nerve agent markers under neutral, basic, and slightly acidic conditions is presented.
Alagu Subramanian +3 more
doaj +2 more sources
In Vitro Interaction of Organophosphono- and Organophosphorothioates with Human Acetylcholinesterase [PDF]
Molecules, 2020 The implementation of the Chemical Weapons Convention (CWC) in 1997 was a milestone in the prohibition of chemical warfare agents (CWA). Yet, the repeated use of CWA underlines the ongoing threat to the population.
Franz Worek +3 more
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Broad-Spectrum Antidote Discovery by Untangling the Reactivation Mechanism of Nerve-Agent-Inhibited Acetylcholinesterase. [PDF]
Chemistry, 2022 Rational design of efficient antidotes to organophosphorus nerve agent (OPNA) intoxication needs to account for the complexity of the molecular system. A fragment with broad‐spectrum binding profile was transformed into a multi‐active reactivator of OPNAs‐inhibited acetylcholinesterases.
Lindgren C +9 more
europepmc +2 more sources
Acetylcholinesterase: Structure, dynamics, and interactions with organophosphorus compounds. [PDF]
Protein SciAbstract Acetylcholinesterase (AChE) is an enzyme that hydrolyzes the neurotransmitter acetylcholine (ACh), removing it from the synaptic cleft after the transmission of an electrical signal, making it an essential component of chemical neurotransmission. AChE is a serine hydrolase, containing a catalytic triad of Ser/His/Glu.
Hung LW +3 more
europepmc +2 more sources
Engineering Enzymes for Environmental Sustainability
Angewandte Chemie, Volume 135, Issue 52, December 21, 2023., 2023 This review highlights how engineered enzymes have been developed and implemented to help address environmental challenges. Topics include the use of engineered enzymes for improving carbon capture and utilisation, bioremediation, plastic deconstruction, and renewable feedstock generation.
Emily Radley +5 more
wiley +2 more sources
Chemical Weapons in the Iran-Iraq War (1980–1988) 3. Medical Consequences of Chemical Warfare
Вестник войск РХБ защиты, 2023 The third article in the series is dedicated to the medical consequences of the chemical warfare between Iran and Iraq during the war (1980–1988). The UN official documents and materials, declassified CIA documents, as well as other open Western and ...
M. V. Supotnitskiy +2 more
doaj +1 more source
Вестник войск РХБ защиты, 2023 The Iran-Iraq war (1980–1988) was the first modern war in which chemical weapons were used. The purpose of this work is to summarize the experience of treating victims, affected by nerve agents. The publications of Iranian authors in different scientific
M. V. Supotnitskiy
doaj +1 more source