Results 41 to 50 of about 674 (166)

Selective surface-enhanced Raman scattering detection of Tabun, VX and Cyclosarin nerve agents using 4-pyridine amide oxime functionalized gold nanopillars [PDF]

, 2020
We have earlier demonstrated sensitive detection of low the volatile nerve agents Tabun, Cyclosarin and VX by using handheld Raman instrumentation in conjunction with surface-enhanced Raman scattering (SERS) attained with gold and silver coated Si ...
Mikaelsson, Therese, Schmidt, Michael Stenbæk, Hakonen, Aron, Juhlin, Lars, Boisen, A.,, Schmidt, Michael Stenb\ue6k, Käll, Mikael, Andersson, Per Ola, Rindzevicius, Tomas,, Andersson, Per Ola,, Schmidt, Michael Stenbaek, Schmidt, Michael Stenbæk,, Rindzevicius, Tomas, Boisen, Anja, Mikaelsson, Therese,, Hakonen, Aron,, Boisen, Anja,, K\ue4ll, Mikael, Boisen, A., Schmidt, Michael Stenbaek,, Käll, Mikael,, Juhlin, Lars,   +21 more
core   +1 more source

Dysbiosis in gastrointestinal pathophysiology: Role of the gut microbiome in Gulf War Illness

Journal of Cellular and Molecular Medicine, Volume 27, Issue 7, Page 891-905, April 2023., 2023
Abstract Gulf War Illness (GWI) has been reported in 25%–35% of veterans returned from the Gulf war. Symptoms of GWI are varied and include both neurological and gastrointestinal symptoms as well as chronic fatigue. Development of GWI has been associated with chemical exposure particularly with exposure to pyridostigmine bromide (PB) and permethrin ...
Elise Slevin, Sachiko Koyama, Kelly Harrison, Ying Wan, James E. Klaunig, Chaodong Wu, Ashok K. Shetty, Fanyin Meng   +7 more
wiley   +1 more source

Aminoalkoxy‐substituted coumarins: Synthesis and evaluation for reactivation of inhibited human acetylcholinesterase

Archiv der Pharmazie, Volume 355, Issue 11, November 2022., 2022
Significant effort has been invested into the development of cholinesterase reactivators that are capable of treating organophosphorus poisoning. A series of 12 coumarin derivatives equipped with linker‐connected nonaromatic terminal amino moieties were prepared in this study.
Paul W. Elsinghorst, Timo Wille, Danijela Barić, Matthias D. Mertens, Madlen Baumann, Jim Küppers, Michael Gütschow   +6 more
wiley   +1 more source

1,3–Bis(2–hydroxyiminomethylpyridinium) Propane as the Potential Reactivator of the Acetylcholinesterase Inhibited by Nerve Agents

Acta Medica, 2004
The oxime K005 [1,3–bis(2–hydroxyiminomethylpyridinium) propane dibromide] for the reactivation of the enzyme acetylcholinesterase (AChE) inhibited by cyclosarin and VX was tested.
Kamil Kuča, Vlastimil Dohnal
doaj   +1 more source

Synthesis of Deuterated Methylphosphonic Acid Derivatives for Use as Standard Compounds in the Analysis of Toxic Chemicals

Вестник войск РХБ защиты, 2021
One of the ways to ensure high reliability of detection, identification and accuracy of quantitative determination of toxic chemicals (TC) in environmental and biomedical samples by gas and liquid chromatography-mass spectrometry methods is to use ...
V. А. Yashkir, V. I. Krylov, I. I. Krylov, A. V. Brown, D. V. Oreshkin, I. V. Rybalchenko, V. N. Fateenkov   +6 more
doaj   +1 more source

Human Carboxylesterase 1 Stereoselectively Binds the Nerve Agent Cyclosarin and Spontaneously Hydrolyzes the Nerve Agent Sarin [PDF]

, 2009
Organophosphorus (OP) nerve agents are potent toxins that inhibit cholinesterases and produce a rapid and lethal cholin-ergic crisis. Development of protein-based therapeutics is be-ing pursued with the goal of preventing nerve agent toxicity and ...
Monika Wierdl, Mary Macdonald, Tamara C. Otto, Matthew R. Redinbo, Fleming, C. D., Hemmert, A. C., Douglas M. Cerasoli, MacDonald, M., Cashman, J. R., Christopher D. Fleming, Edwards, C. C., Carol C. Edwards, Andrew C. Hemmert, Wierdl, M., Potter, P. M., Philip M. Potter, Redinbo, M. R., John R. Cashman, Otto, T. C., Cerasoli, D. M.   +19 more
core   +1 more source

Nerve agent hydrolysis activity designed into a human drug metabolism enzyme. [PDF]

PLoS ONE, 2011
Organophosphorus (OP) nerve agents are potent suicide inhibitors of the essential neurotransmitter-regulating enzyme acetylcholinesterase. Due to their acute toxicity, there is significant interest in developing effective countermeasures to OP poisoning.
Andrew C Hemmert, Tamara C Otto, Roberto A Chica, Monika Wierdl, Jonathan S Edwards, Steven M Lewis, Carol C Edwards, Lyudmila Tsurkan, C Linn Cadieux, Shane A Kasten, John R Cashman, Stephen L Mayo, Philip M Potter, Douglas M Cerasoli, Matthew R Redinbo   +14 more
doaj   +1 more source

Effects of low-level sarin and cyclosarin exposure on hippocampal subfields in Gulf War Veterans [PDF]

NeuroToxicology, 2014
More than 100,000 US troops were potentially exposed to chemical warfare agents sarin (GB) and cyclosarin (GF) when an ammunition dump at Khamisiyah, Iraq was destroyed during the 1991 Gulf War (GW). We previously reported reduced hippocampal volume in GW veterans with suspected GB/GF exposure relative to matched, unexposed GW veterans estimated from 1.
Linda L. Chao, Stephen Kriger, Shannon Buckley, Peter Ng, Susanne G. Mueller   +4 more
openaire   +2 more sources

Potency of new structurally different oximes to reactivate cyclosarin-inhibited human brain acetylcholinesterases [PDF]

Journal of Enzyme Inhibition and Medicinal Chemistry, 2006
Antidotes currently used for organophosphorus pesticide and nerve agent intoxications consist of anticholinergics (atropine mainly) and acetylcholinesterase (AChE, EC 3.1.1.7) reactivators called oximes. Owing to the wide-spread of these toxic compounds worldwide, development of antidotes in the case of first aid is needed. To select the most promising
Kamil, Kuca, Jiri, Cabal, Daniel, Jun, Jiri, Bajgar, Martina, Hrabinova   +4 more
openaire   +2 more sources

In vitro detoxification of cyclosarin in human blood pre-incubated ex vivo with recombinant serum paraoxonases [PDF]

Toxicology Letters, 2011
An ex vivo protocol was developed to assay the antidotal capacity of rePON1 variants to protect endogenous acetylcholinesterase and butyrylcholinesterase in human whole blood against OP nerve agents. This protocol permitted us to address the relationship between blood rePON1 concentrations, their kinetic parameters, and the level of protection ...
Yacov, Ashani, Moshe, Goldsmith, Haim, Leader, Israel, Silman, Joel L, Sussman, Dan S, Tawfik   +5 more
openaire   +2 more sources