Results 61 to 70 of about 1,056 (182)

Therapeutic Efficacy of Different Antidotal Mixtures Against Poisoning with GF-Agent in Mice

Acta Medica, 2004
The toxicity of cyclohexyl methylphosphonofluoridate (GF-agent; cyclosarin) and therapeutic efficacy of four oximes (trimedoxime, methoxime, obidoxime and HI-6) in combination with atropine or benactyzine (BNZ) was studied in mice.
Lucie Bartošová, Gabriela Kunešová, Kamil Kuča, Josef Vachek   +3 more
doaj   +1 more source

Targeting Intracellular Calcium Stores Alleviates Neurological Morbidities in a DFP-Based Rat Model of Gulf War Illness [PDF]

, 2019
Gulf War Illness (GWI) is a chronic multi-symptom disorder afflicting the veterans of the First Gulf War, and includes neurological symptoms characterized by depression and memory deficits.
Blair, Robert, Deshpande, Laxmikant, Phillips, Kristin, Santos, Edna   +3 more
core   +1 more source

Comparison of the structure and activity of glycosylated and asglycosylated human carboxylesterase 1 [PDF]

, 2015
Human Carboxylesterase 1 (hCES1) is the key liver microsomal enzyme responsible for detoxification and metabolism of a variety of clinical drugs. To analyse the role of the single N-linked glycan on the structure and activity of the enzyme, authentically
AC Hemmert, AJ McCoy, Andreas Hofmann, AR Aricescu, CD Fleming, CD Fleming, CL Morton, David J. Scott, DI Stuart, DL Kroetz, DL Kroetz, DL Ollis, EI Parkinson, F Gorrec, G Koshland DN, GN Murshudov, HM Greenblatt, HM Greenblatt, J Monod, J Newman, JA Crow, JE Nettleship, JE Nettleship, JL Vaughn, Joanne E. Nettleship, K Nishi, LA Needham, M Alam, M Husokawa, M Suzuki-Kurasaki, Martin A. Walsh, Michael H. Charlton, MJ Hatfield, Nahid Rahman, NS Berrow, P Emsley, PA Karplus, PJ Reeves, PM Potter, PM Potter, Raymond J. Owens, RM Wadkins, RM Wadkins, RS Holmes, S Bencharit, S Bencharit, S Bencharit, S Bencharit, S Bencharit, S Takahashi, SN Ho, T Satoh, T Satoh, TS Walter, U Boonyuen, Victoria Arena de Souza, VT Chang   +56 more
core   +2 more sources

Toxicological analyses of the bone matrix: Successes and challenges

Archaeometry, Volume 67, Issue 4, Page 1001-1021, August 2025.
Abstract This study aimed to conduct an in‐depth and systematic literature review dealing with toxicological analyses on human bone tissue and focusing on the forensic toxicological and archaeotoxicological field. Several studies have focused their research on medical drugs, drugs of abuse, and trace elements on both human cadavers and skeletal remains,
Gaia Giordano, Lucie Biehler‐Gomez, Cristina Cattaneo, Domenico Di Candia   +3 more
wiley   +1 more source

In vitro detoxification of cyclosarin in human blood pre-incubated ex vivo with recombinant serum paraoxonases [PDF]

Toxicology Letters, 2011
An ex vivo protocol was developed to assay the antidotal capacity of rePON1 variants to protect endogenous acetylcholinesterase and butyrylcholinesterase in human whole blood against OP nerve agents. This protocol permitted us to address the relationship between blood rePON1 concentrations, their kinetic parameters, and the level of protection ...
Yacov, Ashani, Moshe, Goldsmith, Haim, Leader, Israel, Silman, Joel L, Sussman, Dan S, Tawfik   +5 more
openaire   +2 more sources

A Thermostable Bacterial Metallohydrolase that Degrades Organophosphate Plasticizers

ChemBioChem, Volume 26, Issue 11, June 3, 2025.
This bacterial enzyme, cyclase‐phosphotriesterase (C‐PTE) from Ruegeria pomeroyi DSS‐3, shows significant potential for breaking down organophosphate pollutants. Beyond its capability to hydrolyze specific plasticizers such as triphenyl phosphate and tris(2‐chloropropyl) phosphate, C‐PTE's crystal structure reveals a binuclear zinc active site, and it ...
Dawei Ji, Rebecca L. Frkic, Javad Delyami, Joachim S. Larsen, Matthew A. Spence, Colin J. Jackson   +5 more
wiley   +1 more source

Connectivity differences between Gulf War Illness (GWI) phenotypes during a test of attention [PDF]

, 2019
One quarter of veterans returning from the 1990–1991 Persian Gulf War have developed Gulf War Illness (GWI) with chronic pain, fatigue, cognitive and gastrointestinal dysfunction. Exertion leads to characteristic, delayed onset exacerbations that are not
Baraniuk, James N., Clarke, Tomas, Jamieson, Jessie, Malone, Patrick, Rayhan, Rakib U., VanMeter, John W., Washington, Stuart   +6 more
core   +2 more sources

Sulfonatocalix[4]arene‐Based Scavengers for V‐Type Nerve Agents with Enhanced Detoxification Activity

Chemistry – A European Journal, Volume 31, Issue 9, February 12, 2025.
Two is better than one. The introduction of a second hydroxamic acid substituents along the cavity of a sulfonatocalix[4]arene improves the activity with which this compound detoxifies highly toxic nerve agents of the V‐type to such an extent that its use as an antidote is now conceivable.
Patrick Gaß, Sebastiano Casalino, Franz Worek, Stefan Kubik   +3 more
wiley   +1 more source

Detoxification of V‐Nerve Agents Assisted by a Microperoxidase: New Pathway Revealed by the Use of a Relevant VX Simulant

ChemBioChem, Volume 25, Issue 15, August 1, 2024.
The biocatalyzed oxidative detoxification of the V‐series simulant PhX with the microperoxidase AcMP11 affords the corresponding phosphonothioate as the prominent product instead of the classical P−S and P−O bond cleavage. These results highlight the efficacy of AcMP11 to efficiently detoxify V‐series organophosphorus nerve agents and the necessity to ...
Valmir Baptista da Silva, Jean‐Pierre Mahy, Xavier Brazzolotto, Pierre‐Yves Renard, Rémy Ricoux, Julien Legros   +5 more
wiley   +1 more source

Detoxification of Chemical Warfare Agents by a Zr‐Based MOF with High Recycling Ability at Physiological pH

ChemNanoMat, Volume 10, Issue 8, August 2024.
Detoxification of organophosphate (OP) chemical warfare agents is a major concern due to their high toxicity. Previous researches demonstrate Zr‐MOF catalysts efficiently hydrolyzing OPs in highly alkaline pH (~9‐10). However, catalysts for detoxification at physiological pH and with high recycling ability remain limited.
Subharanjan Biswas, Rémy Gay, Janek Bzdrenga, Thomas Soirot, Nicolas Belverge, Nicolas Taudon, Xavier Brazzolotto, Mohamed Haouas, Nathalie Steunou, Jean‐Pierre Mahy, Rémy Ricoux   +10 more
wiley   +1 more source