Results 61 to 70 of about 674 (166)
Chemistry – A European Journal, Volume 31, Issue 9, February 12, 2025.Two is better than one. The introduction of a second hydroxamic acid substituents along the cavity of a sulfonatocalix[4]arene improves the activity with which this compound detoxifies highly toxic nerve agents of the V‐type to such an extent that its use as an antidote is now conceivable.
Patrick Gaß +3 more
wiley +1 more source
ChemBioChem, Volume 25, Issue 15, August 1, 2024.The biocatalyzed oxidative detoxification of the V‐series simulant PhX with the microperoxidase AcMP11 affords the corresponding phosphonothioate as the prominent product instead of the classical P−S and P−O bond cleavage. These results highlight the efficacy of AcMP11 to efficiently detoxify V‐series organophosphorus nerve agents and the necessity to ...
Valmir Baptista da Silva +5 more
wiley +1 more source
, 2016 The inactivation of acetylcholinesterase (AChE) by organophosphorus agent (OP) compounds is a serious problem regardless of how the individual was exposed.
Jeffry D. Madura (1335309) +3 more
core +1 more source
ChemNanoMat, Volume 10, Issue 8, August 2024.Detoxification of organophosphate (OP) chemical warfare agents is a major concern due to their high toxicity. Previous researches demonstrate Zr‐MOF catalysts efficiently hydrolyzing OPs in highly alkaline pH (~9‐10). However, catalysts for detoxification at physiological pH and with high recycling ability remain limited.
Subharanjan Biswas +10 more
wiley +1 more source
ChemPlusChem, Volume 89, Issue 8, August 2024.Fast and reliable detection of Nerve Agents (NAs) in the environment still represent an urgent need in emergency situation. The development of practical, portable sensing technology, accessible to non‐specialized operators, performing fast detection of NAs, still represents a challenge.
Roberta Puglisi +3 more
wiley +1 more source
Supramolecular Approaches to the Detoxification of Nerve Agents
Israel Journal of Chemistry, Volume 64, Issue 6-7, July 2024.Abstract A promising, but not yet practiced, approach to the treatment of neurotoxic organophosphate poisoning is the administration of a scavenger that rapidly deactivates the nerve agent before it can exert its toxic effects. The detoxification rates required for successful use of this therapy can currently only be achieved with enzymes, but ...
Stefan Kubik
wiley +1 more source
Journal of Computational Chemistry, Volume 45, Issue 15, Page 1303-1315, June 5, 2024.Understanding the factors that lead to the formation of the bond between an organophosphorus, specifically chemical warfare agents, and AChE is essential for understanding these systems. This work used DFT techniques, such as AIM, NBO, and EDA, finding indications that this bond is driven by the pnictogen bond and, unlike the usual explanation that ...
Gustavo A. Andolpho +1 more
wiley +1 more source
Recent advances in cholinergic mechanisms as reactions to toxicity, stress, and neuroimmune insults
Journal of Neurochemistry, Volume 168, Issue 4, Page 355-369, April 2024.We reviewed the current advances in our understanding of the effects of a variety of stressors in order to connect acute poisoning with organophosphates, neurotoxicity, changes in microRNAs, and transfer RNA fragments with cholinergic signaling dysfunction.
Zrinka Kovarik +3 more
wiley +1 more source
Recent research on Gulf War illness and other health problems in veterans of the 1991 Gulf War: Effects of toxicant exposures during deployment [PDF]
, 2015 Veterans of Operation Desert Storm/Desert Shield − the 1991 Gulf War (GW) − are a unique population who returned from theater with multiple health complaints and disorders. Studies in the U.S.
O’Callaghan, James P. +29 more
core +2 more sources
Reactivation of hCE1 following nerve agent exposure.
, 2013 A. Spontaneous reactivation of V146H/L363E hCE1 following inhibition by racemic sarin (blue), soman (green), or cyclosarin (red). Wild type hCE1 (grey) only reactivates following sarin inhibition (7). n = 6, s.d. B.
Steven L. Lewis (354519) +14 more
core +1 more source