Results 81 to 90 of about 674 (166)

Enantioseparation, in vitro testing, and structural characterization of triple-binding reactivators of organophosphate-inhibited cholinesterases

, 2020
The enantiomers of racemic 2-hydroxyimino-N-(azidophenylpropyl)acetamide-derived triple-binding oxime reactivators were separated, and tested for inhibition and reactivation of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibited with ...
Kovarik, Zrinka, Rončević, Igor; id_orcid, Maraković, Nikola, Šinko, Goran, Brazzalotto, Xavier, Knežević, Anamarija   +5 more
core   +1 more source

Novel Human Butyrylcholinesterase Variants: Toward Organophosphonate Detoxication

, 2015
Human butyrylcholinesterase (hBChE) is currently being developed as a detoxication enzyme for stoichiometric binding and/or catalytic hydrolysis of organophosphates.
Emily M. Smith (1326564), Beilin Wang (1326558), Jun Zhang (48506), Mary Dwyer (1326561), John R. Cashman (354526), Daniel A. Ryan (1326555), Sacha Javor (1326567)   +6 more
core   +1 more source

Detection of Chemical Warfare Agents with a Miniaturized High-Performance Drift Tube Ion Mobility Spectrometer Using High-Energetic Photons for Ionization. [PDF]

Anal Chem, 2022
Ahrens A, Allers M, Bock H, Hitzemann M, Ficks A, Zimmermann S.   +5 more
europepmc   +1 more source

Monitoring the hydrolysis of toxic organophosphonate nerve agents in aqueous buffer and in bicontinuous microemulsions by use of diisopropyl fluorophosphatase (DFPase) with H-1-P-31 HSQC NMR spectroscopy

, 2010
Gaeb J, Melzer M, Kehe K, Wellert S, Hellweg T, Blum M-M. Monitoring the hydrolysis of toxic organophosphonate nerve agents in aqueous buffer and in bicontinuous microemulsions by use of diisopropyl fluorophosphatase (DFPase) with H-1-P-31 HSQC NMR ...
Gaeb, Juergen, Wellert, Stefan, Blum, Marc-Michael, Kehe, Kai, Hellweg, Thomas ; https://orcid.org/, Melzer, Marco, Hellweg, T., Blum, M. M., Kehe, K., Gäb, J., Melzer, M., Wellert, S.   +11 more
core   +1 more source

Réactivité de la ß-cyclodextrine (Accès à des Epurateurs d organophosphorés neurotoxiques)

, 2010
Les armes chimiques sont encore disponibles et présentent un réel danger pour la population. Récemment, des ß-cyclodextrines ß-CD) fonctionnalisées par un dérivé de l acide 2-iodosobenzoïque ont été développées comme épurateur des organophosphorés ...
LE PROVOST, Romain, LAFONT, Olivier
core  

Synthesis and comparison of activity of potential reactivators of acetylcholinesterase inhibited by cyclosarine

, 2009
SYNTHESIS OF POTENCIAL QUATERNARY ACETYLCHOLINESTERASE REACTIVATORS AND EVALUATION OF THEIR POTENCY TO REACTIVATE CYCLOSARIN-INHIBITED AChE Mgr. Lukáš Lipka Department of pharmaceutical chemistry and drug control, Charles University in Prague, Faculty of
Lipka, Lukáš
core  

Detecting forensic substances using commercially available SERS substrates and handheld Raman spectrometers

, 2018
Ultra-sensitive in-field measurements of most forensic substances still today remain a challenge for first responders and forensic investigators. Handheld Raman spectroscopy equipment is getting more and more routinely used in the field for evidence ...
Stenbæk Schmidt, Michael,, Rindzevicius, Tomas, Schmidt, Michael Stenbæk, Hakonen, Aron, Boisen, Anja, Hakonen, Aron,, Andersson, Per Ola, Wu, Kaiyu, Wy, Kaiy,, Andersson, Per Ola,, Boisen, Anja,, Rindzevicius, Tomas,   +11 more
core   +1 more source

Chemical and Biological Threats, Hazard Potential and Countermeasures. [PDF]

Toxics, 2022
Soukup O, Korabecny J.
europepmc   +1 more source

Computational redesign of a mononuclear zinc metalloenzyme for organophosphate hydrolysis.

, 2012
The ability to redesign enzymes to catalyze noncognate chemical transformations would have wide-ranging applications. We developed a computational method for repurposing the reactivity of metalloenzyme active site functional groups to catalyze new ...
Leader, Haim, Kipnis, Yakov, Barry L Stoddard, Yakov Kipnis, Ryo Takeuchi, Moshe Goldsmith, Takeuchi, Ryo, Dan S Tawfik, Song, Yifan, Tawfik, Dan S., Khare, Sagar D., Israel Silman, David Baker, Haim Leader, Baker, David, Goldsmith, Moshe, Joel L Sussman, Stoddard, Barry L., Jasmine L Gallaher, Silman, Israel, Sagar D Khare, Greisen, Per Junior, Sussman, Joel L, Per Jr Greisen, Ashani, Yacov, Yacov Ashani, Gallaher, Jasmine L, Yifan Song   +27 more
core   +1 more source

Review: Organophosphorus toxicants, in addition to inhibiting acetylcholinesterase activity, make covalent adducts on multiple proteins and promote protein crosslinking into high molecular weight aggregates. [PDF]

Chem Biol Interact, 2023
Lockridge O, Schopfer LM.
europepmc   +1 more source