Results 71 to 80 of about 1,056 (182)
ChemPlusChem, Volume 89, Issue 8, August 2024.Fast and reliable detection of Nerve Agents (NAs) in the environment still represent an urgent need in emergency situation. The development of practical, portable sensing technology, accessible to non‐specialized operators, performing fast detection of NAs, still represents a challenge.
Roberta Puglisi +3 more
wiley +1 more source
Supramolecular Approaches to the Detoxification of Nerve Agents
Israel Journal of Chemistry, Volume 64, Issue 6-7, July 2024.Abstract A promising, but not yet practiced, approach to the treatment of neurotoxic organophosphate poisoning is the administration of a scavenger that rapidly deactivates the nerve agent before it can exert its toxic effects. The detoxification rates required for successful use of this therapy can currently only be achieved with enzymes, but ...
Stefan Kubik
wiley +1 more source
Journal of Computational Chemistry, Volume 45, Issue 15, Page 1303-1315, June 5, 2024.Understanding the factors that lead to the formation of the bond between an organophosphorus, specifically chemical warfare agents, and AChE is essential for understanding these systems. This work used DFT techniques, such as AIM, NBO, and EDA, finding indications that this bond is driven by the pnictogen bond and, unlike the usual explanation that ...
Gustavo A. Andolpho +1 more
wiley +1 more source
Recent advances in cholinergic mechanisms as reactions to toxicity, stress, and neuroimmune insults
Journal of Neurochemistry, Volume 168, Issue 4, Page 355-369, April 2024.We reviewed the current advances in our understanding of the effects of a variety of stressors in order to connect acute poisoning with organophosphates, neurotoxicity, changes in microRNAs, and transfer RNA fragments with cholinergic signaling dysfunction.
Zrinka Kovarik +3 more
wiley +1 more source
Solubilization and Humanization of Paraoxonase-1 [PDF]
, 2012 Paraoxonase-1 (PON1) is a serum protein, the activity of which is related to susceptibility to cardiovascular disease and intoxication by organophosphorus (OP) compounds.
Cerasoli, Douglas M. +8 more
core +2 more sources
Rational Design and Directed Evolution of Human Paraoxonase I (huPON1) for Increased Solubility and Stability in E. coli [PDF]
, 2009 Paraoxonase I (PON1) is a serum hydrolase that has been found to hydrolyze organophosphates (OP), such as VX and sarin. Because human PON1 (huPON1) is a human protein with reasonable activity, it seems like a promising therapeutic agent against OP ...
Matic, George, Jr.
core
Oxidative Stress and Mitochondrial Injury in Chronic Multisymptom Conditions: From Gulf War Illness to Autism Spectrum Disorder [PDF]
, 2012 Background: Overlapping chronic multisymptom illnesses (CMI) include Chronic Fatigue Syndrome (CFS), fibromyalgia, irritable bowel syndrome, multiple chemical sensitivity, and Gulf War illness (GWI), and subsets of autism spectrum disorder (ASD).
Beatrice A. Golomb
core +1 more source
Hydrolysis of G- and V-series organophosphorus nerve agents (OPNAs) containing a phosphorus-methyl bond yields a methylphosphonic acid (MeP) product when adducted to human butyrylcholinesterase (BChE).
core +3 more sources
Preparation of Oxime HI-6 (Dichloride and Dimethanesulphonate)ŒAntidote against Nerve Agents [PDF]
, 2008 Because of the threat of misuse of nerve agents as terroristic weapons by the terrorists, animmediate need is felt for the preparation of antidotes on large-scale basis.
Dolezal, Bohumil +5 more
core +2 more sources
Novel TRPA1 antagonist lead compound and its therapeutic potential in organophosphate poisoning
In Silico Research in BiomedicineOrganophosphate toxicity mediated by the TRPA1 ion channel presents a significant challenge in neurotoxicology. This study computationally explores a novel, potential inhibitory site within the TRPA1 channel pore, centered on the Serine 1039 residue ...
Shreya Satyanarayan Bhat +3 more
doaj +1 more source