Results 71 to 80 of about 687 (168)

Pyridinium Oximes with Ortho-Positioned Chlorine Moiety Exhibit Improved Physicochemical Properties and Efficient Reactivation of Human Acetylcholinesterase Inhibited by Several Nerve Agents

, 2018
Six chlorinated bispyridinium mono-oximes, analogous to potent charged reactivators K027, K048, and K203, were synthesized with the aim of improving lipophilicity and reducing the pKa value of the oxime group, thus resulting in a higher oximate ...
Ondrej Soukup (1475038), Tamara Zorbaz (5988824), David Malinak, Adam Skarka (5988833), Nikolina Maček Hrvat, Maja Katalinić, Kamil Musilek, Kamil Musilek (1476094), Kamil Kuca (1474993), Marketa Benkova (4850329), Nikolina Maček Hrvat (1599688), Maja Katalinić (1599685), Zrinka Kovarik (1599691), Adam Skarka, Ondrej Soukup, Kamil Kuca, Antonio Zandona (5988830), Nikola Maraković (5988827), Antonio Zandona, Nikola Maraković, David Malinak (1475035), Rudolf Andrys (5988836), Rudolf Andrys, Michal Novotny (3134412), Tamara Zorbaz, Marketa Benkova, Michal Novotny, Zrinka Kovarik   +27 more
core   +2 more sources

Detoxification of Chemical Warfare Agents by a Zr‐Based MOF with High Recycling Ability at Physiological pH

ChemNanoMat, Volume 10, Issue 8, August 2024.
Detoxification of organophosphate (OP) chemical warfare agents is a major concern due to their high toxicity. Previous researches demonstrate Zr‐MOF catalysts efficiently hydrolyzing OPs in highly alkaline pH (~9‐10). However, catalysts for detoxification at physiological pH and with high recycling ability remain limited.
Subharanjan Biswas, Rémy Gay, Janek Bzdrenga, Thomas Soirot, Nicolas Belverge, Nicolas Taudon, Xavier Brazzolotto, Mohamed Haouas, Nathalie Steunou, Jean‐Pierre Mahy, Rémy Ricoux   +10 more
wiley   +1 more source

Recent research on Gulf War illness and other health problems in veterans of the 1991 Gulf War: Effects of toxicant exposures during deployment [PDF]

, 2015
Veterans of Operation Desert Storm/Desert Shield − the 1991 Gulf War (GW) − are a unique population who returned from theater with multiple health complaints and disorders. Studies in the U.S.
O’Callaghan, James P., Bunker, James A, Binns, James H, Graves, Joel C., Bunker, Bloo, Graves, Joel C, Grashow, Rachel, Knox, Marguerite, Bloom, Floyd E., Kilmas, Nancy, Philbert, Martin A., NC DOCKS at East Carolina University, O'Callaghan, James P, Crawford, Fiona, Steele, Lea, Philbert, Martin A, Klimas, Nancy, Bloom, Floyd E, O'Callaghan, James P., Binns, James H., White, Roberta F, Meggs, William J., Meggs, William J, Hardie, Anthony, Golomb, Beatrice A, Golomb, Beatrice A., White, Roberta F., Melling, Jack, Sullivan, Kimberly, Bunker, James A.   +29 more
core   +2 more sources

Smart Sensing of Nerve Agents

ChemPlusChem, Volume 89, Issue 8, August 2024.
Fast and reliable detection of Nerve Agents (NAs) in the environment still represent an urgent need in emergency situation. The development of practical, portable sensing technology, accessible to non‐specialized operators, performing fast detection of NAs, still represents a challenge.
Roberta Puglisi, Rossella Santonocito, Andrea Pappalardo, Giuseppe Trusso Sfrazzetto   +3 more
wiley   +1 more source

Supramolecular Approaches to the Detoxification of Nerve Agents

Israel Journal of Chemistry, Volume 64, Issue 6-7, July 2024.
Abstract A promising, but not yet practiced, approach to the treatment of neurotoxic organophosphate poisoning is the administration of a scavenger that rapidly deactivates the nerve agent before it can exert its toxic effects. The detoxification rates required for successful use of this therapy can currently only be achieved with enzymes, but ...
Stefan Kubik
wiley   +1 more source

Pnictogen bond‐driven control of the molecular interaction between organophosphorus and acetylcholinesterase enzyme

Journal of Computational Chemistry, Volume 45, Issue 15, Page 1303-1315, June 5, 2024.
Understanding the factors that lead to the formation of the bond between an organophosphorus, specifically chemical warfare agents, and AChE is essential for understanding these systems. This work used DFT techniques, such as AIM, NBO, and EDA, finding indications that this bond is driven by the pnictogen bond and, unlike the usual explanation that ...
Gustavo A. Andolpho, Teodorico C. Ramalho   +1 more
wiley   +1 more source

Reactivation of hCE1 following nerve agent exposure.

, 2013
A. Spontaneous reactivation of V146H/L363E hCE1 following inhibition by racemic sarin (blue), soman (green), or cyclosarin (red). Wild type hCE1 (grey) only reactivates following sarin inhibition (7). n = 6, s.d. B.
Steven L. Lewis (354519), Matthew R. Redinbo (93591), Carol C. Edwards (354521), Tamara C. Otto (350617), Philip M. Potter (23125), Douglas M. Cerasoli (350618), C. Linn Cadieux (354524), John R. Cashman (354526), Lyudmila Tsurkan (354523), Shane A. Kasten (354525), Roberto A. Chica (109101), Stephen L. Mayo (109096), Monika Wierdl (354512), Jonathan S. Edwards (354516), Andrew C. Hemmert (354510)   +14 more
core   +1 more source

Recent advances in cholinergic mechanisms as reactions to toxicity, stress, and neuroimmune insults

Journal of Neurochemistry, Volume 168, Issue 4, Page 355-369, April 2024.
We reviewed the current advances in our understanding of the effects of a variety of stressors in order to connect acute poisoning with organophosphates, neurotoxicity, changes in microRNAs, and transfer RNA fragments with cholinergic signaling dysfunction.
Zrinka Kovarik, Gilli Moshitzky, Nikolina Maček Hrvat, Hermona Soreq   +3 more
wiley   +1 more source

Analogues with Fluorescent Leaving Groups for Screening and Selection of Enzymes That Efficiently Hydrolyze Organophosphorus Nerve Agents

, 2016
Enzymes that efficiently hydrolyze highly toxic organophosphorus nerve agents could potentially be used as medical countermeasures. As sufficiently active enzymes are currently unknown, we synthesized twelve fluorogenic analogues of organophosphorus ...
Gareth R. Williams (538728), Alan R. Fersht (5589), Andy P. Smith (2655121), Janet Wetherell (2655124), David Sellers (2655118), Christopher M. Timperley (783508), Stuart Notman (2361871), Jim Hill (2655115), Andrew D. Griffiths (1898392), Nichola H. Williams (2655112), Luis Briseño-Roa (227389)   +10 more
core   +1 more source

The therapeutic efficacy of oxime treatment in cyclosarin-poisoned mice pretreated with a combination of pyridostigmine benactyzine and trihexyphenidyl [PDF]

Journal of Applied Biomedicine, 2004
Summary The present study was performed to assess and compare the therapeutic efficacy of various oximes (methoxime, BI-6, HI-6) combined with benactyzine (BNZ) in cyclosarin (GF-agent)-poisoned mice and to evaluate the influence of pretreatment with PANPAL (pyridostigmine, benactyzine and trihexyphenidyl) on the effect of antidotal treatment in mice ...
Lucie Ševelová, Kamil Kuča, Gabriela Krejčová, Josef Vachek   +3 more
openaire   +1 more source