Results 1 to 10 of about 21,733 (146)

Triple potentiator combinations increase the functional correction of several CFTR gating mutants [PDF]

npj Drug Discovery
The Trikafta drug combination, comprising the corrector tezacaftor (VX-661), the potentiator ivacaftor (VX-770) and the dual corrector/potentiator elexacaftor (VX-445), has been FDA-approved for treatment of cystic fibrosis caused by ~300 cystic fibrosis
Guido Veit, Christian Vaccarin, Márton A. Simon, Haijin Xu, Houriyeh Hajizadeh, Tina He, Adriana Chilin, Elias Matouk, László Csanády, Giovanni Marzaro, Gergely L. Lukacs   +10 more
doaj   +2 more sources

The Antidepressant Vortioxetine Potently Inhibits Cell Growth in Cultured Human Glioblastoma Cells Expressing 5-HT_1B Serotonin Receptors [PDF]

Cells
Background: Recent evidence suggests that the antidepressant vortioxetine (Vx) inhibits the growth of glioblastoma (GBM), the most aggressive primary malignant tumor of the CNS.
Veronica Russo, Miriam Russo, Maria Antonietta Oliva, Marika Alborghetti, Sonia Castaldi, Luisa Di Menna, Giuseppe Battaglia, Ferdinando Nicoletti, Matteo Caridi, Antonietta Arcella   +9 more
doaj   +2 more sources

Gingival Verruciform Xanthoma: A Rare Case Report With Updated Insights Into Pathogenesis [PDF]

Case Reports in Dentistry
Verruciform xanthoma (VX) is a rare, reactive oral mucosal lesion that can mimic other papillary or verrucous hyperplastic conditions. The present report is of a gingival VX that clinically resembled other papillary lesions. A 14-year-old male reported a
J. Jeevarathan, S. Leena Sankari, Mohammed A. Assiri, S. Myvizhipriyadharshini, Siraj D. A. A. Khan, Khadijah Mohideen, Layla Hafed   +6 more
doaj   +2 more sources

Giant vulvar verruciform xanthoma in a child: a rare case report and literature review [PDF]

Frontiers in Medicine
Verruciform xanthoma (VX) is a rare benign mucocutaneous proliferative lesion that primarily affects the oral mucosa and, in rare cases, the genital mucosa and skin.
Yan Xia, Ying Liu, Hongyan Jiang, Hongsheng Xia, Bin Dong   +4 more
doaj   +2 more sources

Assessment of Seminal L-Carnitine in Infertile Men with Varicocele [PDF]

Egyptian Journal of Medical Research, 2022
Introduction: Most studies that linked varicocele (Vx) with male infertility focused mainly on the testis affection, yet it was suggested that Vx can disturb also the epididymis that plays a central role in sperm maturation.
Mohamed Aabdallah, Taymour Ibrahim, Khadiga Abugabal, Ahmed AboSief   +3 more
doaj   +1 more source

Chemical Weapons in the Iran-Iraq War (1980-1988) Iraq Preparing for Chemical War

Вестник войск РХБ защиты, 2023
The Iraqis became the first nation to use chemical weapons on the modern battlefield during the IranIraq War (1980-1988). There are no general reviews and research available on this issue in Russian.
M. V. Supotnitskiy, N. I. Shilo, V. A. Kovtun   +2 more
doaj   +1 more source

Russian VX: Inhibition and Reactivation of Acetylcholinesterase Compared with VX Agent [PDF]

Basic & Clinical Pharmacology & Toxicology, 2006
Abstract: Organophosphorus compounds such as nerve agents inhibit, practically irreversibly, cholinesterases by their phosphorylation in the active site of these enzymes. Current antidotal treatment used in the case of acute nerve agent intoxications consists of combined administration of anticholinergic drug (usually atropine) and acetylcholinesterase
Kamil, Kuca, Daniel, Jun, Jiri, Cabal, Martina, Hrabinova, Lucie, Bartosova, Veronika, Opletalova   +5 more
openaire   +2 more sources

Emphasis on Temporal Association between Oral Verruciform Xanthoma and Candidal Infection: A Case Report [PDF]

Journal of Clinical and Diagnostic Research, 2023
Oral Verruciform Xanthoma (VX) is a verrucopapillary lesion seen as a cauliflower-like/papillary growth in the oral cavity. The aetiopathophysiology of VX is explained by several pathogenic processes.
Reshma Poothakulath Krishnan, Deepak Pandiar   +1 more
doaj   +1 more source

Pseudomonas aeruginosa Reduces VX-809 Stimulated F508del-CFTR Chloride Secretion by Airway Epithelial Cells. [PDF]

PLoS ONE, 2015
P. aeruginosa is an opportunistic pathogen that chronically infects the lungs of 85% of adult patients with Cystic Fibrosis (CF). Previously, we demonstrated that P. aeruginosa reduced wt-CFTR Cl secretion by airway epithelial cells.
Bruce A Stanton, Bonita Coutermarsh, Roxanna Barnaby, Deborah Hogan   +3 more
doaj   +1 more source

Treatment of Polarized Cystic Fibrosis Airway Cells With HGF Prevents VX-661-Rescued F508del-CFTR Destabilization Caused by Prolonged Co-exposure to VX-770

Frontiers in Molecular Biosciences, 2021
Cystic fibrosis (CF), the most common inherited disease in Caucasians, is caused by mutations in CFTR, the most frequent of which is F508del. F508del causes ER retention and degradation of the mutant CFTR protein, but also defective channel gating and ...
Ana M. Matos, Ana M. Matos, Peter Jordan, Peter Jordan, Paulo Matos, Paulo Matos   +5 more
doaj   +1 more source