Results 1 to 10 of about 24,286 (193)

Combined effects of VX-770 and VX-809 on several functional abnormalities of F508del-CFTR channels [PDF]

Journal of Cystic Fibrosis, 2014
BackgroundThe most common cystic fibrosis-associated mutation, the deletion of phenylalanine 508 (F508del), results in channels with poor membrane expression and impaired function.
Kopeikin, Z., Bompadre, S.G., Yang, H.-Y., Yuksek, Z.   +3 more
core   +3 more sources

Toxicokinetics of (±)-VX in hairless guinea pigs and marmosets - in vitro metabolism of (±)-VX

, 2000
Although the toxicokinetics of several nerve gases, such as sarin and soman have been thoroughly investigated, the toxicokinetics of (±)-VX are still poorly understood.
Wiel, H.J. van der, Lander, H.J., Schans, M.J. van der, Langenberg, J.P., Moes, G.W.H., Benschop, H.P.   +5 more
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Mislocalization of CFTR expression in acute pancreatitis and the beneficial effect of VX‐661 + VX‐770 treatment on disease severity [PDF]

, 2021
Cystic fibrosis transmembrane conductance regulator (CFTR) is an important ion channel in epithelial cells. Its malfunction has several serious consequences, like developing or aggravating acute pancreatitis (AP).
Lóránd Kiss, József Maléth, Fűr, Gabriella, Venglovecz, Viktória, Kiss, Lóránd, Hegyi, Péter, Zsolt Balla, Balla, Zsolt, Beáta Czira, Eszter Sára Kormányos, Rakonczay, Zoltán, Gabriella Fűr, Bálint, Emese Réka, Dénes Péter Kovács, Attila Szűcs, Petra Pallagi, Erik Márk Orján, Kormányos, Eszter Sára, Péter Hegyi, Pallagi, Petra, Orján, Erik Márk, Emese Réka Bálint, Viktória Venglovecz, Zoltán Rakonczay, Maléth, József   +24 more
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Russian VX: Inhibition and Reactivation of Acetylcholinesterase Compared with VX Agent [PDF]

Basic & Clinical Pharmacology & Toxicology, 2006
Abstract: Organophosphorus compounds such as nerve agents inhibit, practically irreversibly, cholinesterases by their phosphorylation in the active site of these enzymes. Current antidotal treatment used in the case of acute nerve agent intoxications consists of combined administration of anticholinergic drug (usually atropine) and acetylcholinesterase
Kamil, Kuca, Daniel, Jun, Jiri, Cabal, Martina, Hrabinova, Lucie, Bartosova, Veronika, Opletalova   +5 more
openaire   +2 more sources

Clinical activity of a htert (vx-001) cancer vaccine as post-chemotherapy maintenance immunotherapy in patients with stage IV non-small cell lung cancer: final results of a randomised phase 2 clinical trial [PDF]

, 2020
The cancer vaccine Vx-001, which targets the universal tumour antigen TElomerase Reverse Transcriptase (TERT), can mount specific Vx-001/TERT CD8 + cytotoxic T cells; this immune response is associated with improved overall survival (OS) in patients with
Syrigos, Kostantinos N., Kotsakis, Athanasios, Vetsika, Eleni-Kyriaki, Cesare Gridelli, Ciuleanu, Tudor, de-Las-Penas, Ramon, Majem, Margarita, Georgoulias, Vassilis, Magdalena Korozan, Frank Griesinger, Jamet, Jeanne-Menez, Isabel Bover, Kosmatopoulos, Kostas, de las Peñas, Ramon, Ciuleanu, Tudor Eliade, Eleni- Kyriaki Vetsika, Szczesna, Aleksandra, Manuel Cobo, Andrzej Kazarnowisz, Margarita Majem, Thierry Chinet, Kostas Kosmatopoulos, Catherine Gallou, Kalofonos, Charalobos, Evangelos Bournakis, Kentepozidis, Nikolaos, Correale, Pierpaolo, Athanasios Kotsakis, Korozan, Magdalena, Gridelli, Cesare, Aleksandra Szczesna, Zarogoulidis, Konstantinos, Gallou, Catherine, Tudor Ciuleanu, Kalofonos, Charalabos, Jamet, Jeanne- Menez, Ramon de las Penas, Manuel Domine, Sadjadian, Parvis, Konstantinos Zarogoulidis, Pierpaolo Correale, Dómine Gómez, Manuel, Vx-001-201 trial team, Nikolaos Kentepozidis, Chinet, Thierry, Charalabos Kalofonos, Bover, Isabel, Griesinger, Frank, Vassilis Georgoulias, Kazarnowisz, Andrzej, Jeanne- Menez Jamet, Kostantinos N. Syrigos, Vetsika, Eleni- Kyriaki, Cobo, Manuel, Chella, Antonio, Bournakis, Evangelos, Domine, Manuel, Antonio Chella, Universitat Autònoma de Barcelona, Parvis Sadjadian, Syrigos, Kostantinos N   +60 more
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Theratyping of the Rare CFTR Genotype A559T in Rectal Organoids and Nasal Cells Reveals a Relevant Response to Elexacaftor (VX-445) and Tezacaftor (VX-661) Combination [PDF]

, 2023
Despite the promising results of new CFTR targeting drugs designed for the recovery of F508del- and class III variants activity, none of them have been approved for individuals with selected rare mutations, because uncharacterized CFTR variants lack ...
Kleinfelder K., Castaldo G., Laudanna C., Amato F., Sorio C., Hristodor A. M., Melotti P., Villella V. R.   +7 more
core   +3 more sources

Mechanism-based corrector combination restores ΔF508-CFTR folding and function. [PDF]

, 2013
The most common cystic fibrosis mutation, Delta F508 in nucleotide binding domain 1 (NBD1), impairs cystic fibrosis transmembrane conductance regulator (CFTR)-coupled domain folding, plasma membrane expression, function and stability. VX-809, a promising
Okiyoneda, T., Beekman, Jeffrey, Verkman, Alan, Soya, N., Bagdany, Miklos, Dekkers, J. F., Kurth, Mark, Lukacs, Gergely, Veit, G., Veit, Guido, Beekman, Jeffrey M., Hegedűs, Tamás, Soya, Naoto, Bagdany, M., Lukacs, Gergely L., Dekkers, Johanna, Xu, Haijin, Okiyoneda, Tsukasa, Verkman, Alan S., Simon, Ágnes, Roldan, Ariel, Dekkers, Johanna F.   +21 more
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VX toxicity in the Göttingen minipig [PDF]

Toxicology Letters, 2016
The present experiments determined the intramuscular LD50 of VX in male Göttingen minipigs at two stages of development. In pubertal animals (115 days old), the LD50 of VX was indeterminate, but approximated 33.3μg/kg. However, in sexually mature animals (152 days old), the LD50 was estimated to be only 17.4μg/kg.
Jeffrey L, Langston, Todd M, Myers
openaire   +2 more sources

The Pulsation Spectrum of VX Hydrae [PDF]

Publications of the Astronomical Society of the Pacific, 2009
14 pages, 5 figures, published in Publications of the Astronomical Society of the Pacific, v.121, p.1076 (October 2009)
Templeton, M. R., Samolyk, G., Dvorak, S., Poklar, R., Butterworth, N., Gerner, H.   +5 more
openaire   +2 more sources

Treatment of Polarized Cystic Fibrosis Airway Cells With HGF Prevents VX-661-Rescued F508del-CFTR Destabilization Caused by Prolonged Co-exposure to VX-770 [PDF]

, 2021
Cystic fibrosis (CF), the most common inherited disease in Caucasians, is caused by mutations in CFTR, the most frequent of which is F508del. F508del causes ER retention and degradation of the mutant CFTR protein, but also defective channel gating and
Matos, Ana M., Jordan, Peter, Matos, Paulo   +2 more
core   +1 more source