Results 11 to 20 of about 27,703 (234)

The modulatory action of C-Vx substance on the immune system in COVID-19 [PDF]

Emerging Microbes and Infections, 2022
The modulatory effect of C-Vx, a novel therapeutic agent, on the immune system of COVID-19 patients was investigated. The functions of T and NK cells of COVID-19 patients with different disease severity were evaluated by flow cytometry in response to C ...
Ilhan Tahrali, Nilgun Akdeniz, Vuslat Yilmaz, Umut C. Kucuksezer, Fatma B. Oktelik, Ozkan Ozdemir, Esin Cetin-Aktas, Yelda Ogutmen, Arzu Ergen, Neslihan Abaci, Erdem Tuzun, Oral Oncul, Gunnur Deniz   +12 more
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Theratyping of the Rare CFTR Genotype A559T in Rectal Organoids and Nasal Cells Reveals a Relevant Response to Elexacaftor (VX-445) and Tezacaftor (VX-661) Combination [PDF]

, 2023
Despite the promising results of new CFTR targeting drugs designed for the recovery of F508del- and class III variants activity, none of them have been approved for individuals with selected rare mutations, because uncharacterized CFTR variants lack ...
Sorio, Claudio, Kleinfelder, Karina, Karina Kleinfelder, Giuseppe Castaldo, Felice Amato, Claudio Sorio, Hristodor, Anca Manuela, Villella, Valeria Rachela, Laudanna, Carlo, Amato, Felice, Anca Manuela Hristodor, Carlo Laudanna, Melotti, Paola, Valeria Rachela Villella, Paola Melotti, Castaldo, Giuseppe, Kleinfelder K., Castaldo G., Laudanna C., Hristodor A. M., Amato F., Sorio C., Melotti P., Villella V. R.   +23 more
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Toxicokinetics of (±)-VX in hairless guinea pigs and marmosets - in vitro metabolism of (±)-VX

, 2000
Although the toxicokinetics of several nerve gases, such as sarin and soman have been thoroughly investigated, the toxicokinetics of (±)-VX are still poorly understood.
Wiel, H.J. van der, Lander, H.J., Schans, M.J. van der, Langenberg, J.P., Moes, G.W.H., Benschop, H.P.   +5 more
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VX-702 Ameliorates the Severity of Sepsis-Associated Acute Kidney Injury by Downregulating Inflammatory Factors in Macrophages [PDF]

Journal of Inflammation Research
Yue Han,* Jingyi Wang,* Jin Zhang,* Xi Zheng, Yijia Jiang, Wei Liu, Wenxiong Li Department of Surgical Intensive Care Unit, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, People’s Republic of China*These authors ...
Han Y, Wang J, Zhang J, Zheng X, Jiang Y, Liu W, Li W   +6 more
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Russian VX: Inhibition and Reactivation of Acetylcholinesterase Compared with VX Agent [PDF]

Basic & Clinical Pharmacology & Toxicology, 2006
Abstract: Organophosphorus compounds such as nerve agents inhibit, practically irreversibly, cholinesterases by their phosphorylation in the active site of these enzymes. Current antidotal treatment used in the case of acute nerve agent intoxications consists of combined administration of anticholinergic drug (usually atropine) and acetylcholinesterase
Kamil, Kuca, Daniel, Jun, Jiri, Cabal, Martina, Hrabinova, Lucie, Bartosova, Veronika, Opletalova   +5 more
openaire   +2 more sources

Mislocalization of CFTR expression in acute pancreatitis and the beneficial effect of VX‐661 + VX‐770 treatment on disease severity

, 2021
Cystic fibrosis transmembrane conductance regulator (CFTR) is an important ion channel in epithelial cells. Its malfunction has several serious consequences, like developing or aggravating acute pancreatitis (AP).
Lóránd Kiss, József Maléth, Fűr, Gabriella, Venglovecz, Viktória, Kiss, Lóránd, Hegyi, Péter, Zsolt Balla, Balla, Zsolt, Beáta Czira, Eszter Sára Kormányos, Rakonczay, Zoltán, Gabriella Fűr, Bálint, Emese Réka, Dénes Péter Kovács, Attila Szűcs, Petra Pallagi, Erik Márk Orján, Kormányos, Eszter Sára, Péter Hegyi, Pallagi, Petra, Orján, Erik Márk, Emese Réka Bálint, Viktória Venglovecz, Zoltán Rakonczay, Maléth, József   +24 more
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Clinical activity of a htert (vx-001) cancer vaccine as post-chemotherapy maintenance immunotherapy in patients with stage IV non-small cell lung cancer: final results of a randomised phase 2 clinical trial [PDF]

, 2020
The cancer vaccine Vx-001, which targets the universal tumour antigen TElomerase Reverse Transcriptase (TERT), can mount specific Vx-001/TERT CD8 + cytotoxic T cells; this immune response is associated with improved overall survival (OS) in patients with
Syrigos, Kostantinos N., Kotsakis, Athanasios, Vetsika, Eleni-Kyriaki, Cesare Gridelli, Ciuleanu, Tudor, de-Las-Penas, Ramon, Majem, Margarita, Georgoulias, Vassilis, Magdalena Korozan, Frank Griesinger, Jamet, Jeanne-Menez, Isabel Bover, Kosmatopoulos, Kostas, de las Peñas, Ramon, Ciuleanu, Tudor Eliade, Eleni- Kyriaki Vetsika, Szczesna, Aleksandra, Manuel Cobo, Andrzej Kazarnowisz, Margarita Majem, Thierry Chinet, Kostas Kosmatopoulos, Catherine Gallou, Kalofonos, Charalobos, Evangelos Bournakis, Kentepozidis, Nikolaos, Correale, Pierpaolo, Athanasios Kotsakis, Korozan, Magdalena, Gridelli, Cesare, Aleksandra Szczesna, Zarogoulidis, Konstantinos, Gallou, Catherine, Tudor Ciuleanu, Kalofonos, Charalabos, Jamet, Jeanne- Menez, Ramon de las Penas, Manuel Domine, Sadjadian, Parvis, Konstantinos Zarogoulidis, Pierpaolo Correale, Dómine Gómez, Manuel, Vx-001-201 trial team, Nikolaos Kentepozidis, Chinet, Thierry, Charalabos Kalofonos, Bover, Isabel, Griesinger, Frank, Vassilis Georgoulias, Kazarnowisz, Andrzej, Jeanne- Menez Jamet, Kostantinos N. Syrigos, Vetsika, Eleni- Kyriaki, Cobo, Manuel, Chella, Antonio, Bournakis, Evangelos, Domine, Manuel, Antonio Chella, Universitat Autònoma de Barcelona, Parvis Sadjadian, Syrigos, Kostantinos N, Majem Tarruella, Margarita   +61 more
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The use of VX as a terrorist agent: action by Aum Shinrikyo of Japan and the death of Kim Jong-Nam in Malaysia: four case studies

Global Security: Health, Science and Policy, 2020
VX is a strong nerve-gas agent. In this paper, murder or injury of human made by VX is reported. First use of VX against human was made by Aum Shimrikyo in 1994 and 1995. More recently, VX was used in the assassination of Mr. Kim Jong-Nam in Kuala Lumpur,
Anthony T. Tu
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Valerio Magrelli. Geologia di un padre (fragmenten)

Incontri: Rivista Europea di Studi Italiani, 2017
Vertaling: Emilia ...
Emilia Menkveld
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Reactivation of VX-Inhibited Human Acetylcholinesterase by Deprotonated Pralidoxime. A Complementary Quantum Mechanical Study

Biomolecules, 2020
In the present work, we performed a complementary quantum mechanical (QM) study to describe the mechanism by which deprotonated pralidoxime (2-PAM) could reactivate human (Homo sapiens sapiens) acetylcholinesterase (HssAChE) inhibited by the nerve agent ...
Jorge Alberto Valle da Silva, Ander Francisco Pereira, Steven R. LaPlante, Kamil Kuca, Teodorico Castro Ramalho, Tanos Celmar Costa França   +5 more
doaj   +1 more source