Results 11 to 20 of about 27,247 (245)

The modulatory action of C-Vx substance on the immune system in COVID-19

Emerging Microbes and Infections, 2022
The modulatory effect of C-Vx, a novel therapeutic agent, on the immune system of COVID-19 patients was investigated. The functions of T and NK cells of COVID-19 patients with different disease severity were evaluated by flow cytometry in response to C ...
Ilhan Tahrali, Nilgun Akdeniz, Vuslat Yilmaz, Umut C. Kucuksezer, Fatma B. Oktelik, Ozkan Ozdemir, Esin Cetin-Aktas, Yelda Ogutmen, Arzu Ergen, Neslihan Abaci, Erdem Tuzun, Oral Oncul, Gunnur Deniz   +12 more
doaj   +2 more sources

Combined effects of VX-770 and VX-809 on several functional abnormalities of F508del-CFTR channels [PDF]

Journal of Cystic Fibrosis, 2014
The most common cystic fibrosis-associated mutation, the deletion of phenylalanine 508 (F508del), results in channels with poor membrane expression and impaired function. VX-770, a clinically approved drug for treatment of CF patients carrying the G551D mutation, and VX-809, a corrector shown in vitro to increase membrane expression of mutant channels,
Kopeikin, Z., Yuksek, Z., Yang, H.-Y., Bompadre, S.G.   +3 more
openaire   +4 more sources

VX-702 Ameliorates the Severity of Sepsis-Associated Acute Kidney Injury by Downregulating Inflammatory Factors in Macrophages [PDF]

Journal of Inflammation Research
Yue Han,* Jingyi Wang,* Jin Zhang,* Xi Zheng, Yijia Jiang, Wei Liu, Wenxiong Li Department of Surgical Intensive Care Unit, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, People’s Republic of China*These authors ...
Han Y, Wang J, Zhang J, Zheng X, Jiang Y, Liu W, Li W   +6 more
doaj   +1 more source

Mislocalization of CFTR expression in acute pancreatitis and the beneficial effect of VX-661 + VX-770 treatment on disease severity [PDF]

, 2021
Cystic fibrosis transmembrane conductance regulator (CFTR) is an important ion channel in epithelial cells. Its malfunction has several serious consequences, like developing or aggravating acute pancreatitis (AP).
Pallagi Petra, Kovács Dénes Péter, Orján Erik Márk, Venglovecz Viktória, Balla Zsolt, Kormányos Eszter Sára, Maléth József, Czira Beáta, Rakonczay Zoltán Jr., Szűcs Attila, Fűr Gabriella, Bálint Emese Réka, Hegyi Péter, Kiss Lóránd   +13 more
core   +2 more sources

Clinical activity of a htert (vx-001) cancer vaccine as post-chemotherapy maintenance immunotherapy in patients with stage IV non-small cell lung cancer: final results of a randomised phase 2 clinical trial [PDF]

, 2020
The cancer vaccine Vx-001, which targets the universal tumour antigen TElomerase Reverse Transcriptase (TERT), can mount specific Vx-001/TERT CD8 + cytotoxic T cells; this immune response is associated with improved overall survival (OS) in patients with
Syrigos, Kostantinos N., Kotsakis, Athanasios, Vetsika, Eleni-Kyriaki, Cesare Gridelli, Ciuleanu, Tudor, de-Las-Penas, Ramon, Majem, Margarita, Georgoulias, Vassilis, Magdalena Korozan, Frank Griesinger, Jamet, Jeanne-Menez, Isabel Bover, Kosmatopoulos, Kostas, de las Peñas, Ramon, Ciuleanu, Tudor Eliade, Eleni- Kyriaki Vetsika, Szczesna, Aleksandra, Manuel Cobo, Andrzej Kazarnowisz, Margarita Majem, Thierry Chinet, Kostas Kosmatopoulos, Catherine Gallou, Kalofonos, Charalobos, Evangelos Bournakis, Kentepozidis, Nikolaos, Correale, Pierpaolo, Athanasios Kotsakis, Korozan, Magdalena, Gridelli, Cesare, Aleksandra Szczesna, Zarogoulidis, Konstantinos, Gallou, Catherine, Tudor Ciuleanu, Kalofonos, Charalabos, Jamet, Jeanne- Menez, Ramon de las Penas, Manuel Domine, Sadjadian, Parvis, Konstantinos Zarogoulidis, Pierpaolo Correale, Dómine Gómez, Manuel, Vx-001-201 trial team, Nikolaos Kentepozidis, Chinet, Thierry, Charalabos Kalofonos, Bover, Isabel, Griesinger, Frank, Vassilis Georgoulias, Kazarnowisz, Andrzej, Jeanne- Menez Jamet, Kostantinos N. Syrigos, Vetsika, Eleni- Kyriaki, Cobo, Manuel, Chella, Antonio, Bournakis, Evangelos, Domine, Manuel, Antonio Chella, Universitat Autònoma de Barcelona, Parvis Sadjadian, Syrigos, Kostantinos N   +60 more
core   +1 more source

Theratyping of the Rare CFTR Genotype A559T in Rectal Organoids and Nasal Cells Reveals a Relevant Response to Elexacaftor (VX-445) and Tezacaftor (VX-661) Combination [PDF]

, 2023
Despite the promising results of new CFTR targeting drugs designed for the recovery of F508del- and class III variants activity, none of them have been approved for individuals with selected rare mutations, because uncharacterized CFTR variants lack ...
Kleinfelder K., Castaldo G., Laudanna C., Amato F., Sorio C., Hristodor A. M., Melotti P., Villella V. R.   +7 more
core   +3 more sources

On reciprocal degree distance of graphs

Heliyon, 2023
Given a connected graph H, its reciprocal degree distance is defined asRDD(H)=∑x≠ydH(vx)+dH(vy)dH(vx,vy), where dH(vx) denotes the degree of the vertex vx in the graph H and dH(vx,vy) is the shortest distance between vx and vy in H.
Mingqiang An, Yinan Zhang, Kinkar Chandra Das, Yilun Shang   +3 more
doaj   +1 more source

The use of VX as a terrorist agent: action by Aum Shinrikyo of Japan and the death of Kim Jong-Nam in Malaysia: four case studies

Global Security: Health, Science and Policy, 2020
VX is a strong nerve-gas agent. In this paper, murder or injury of human made by VX is reported. First use of VX against human was made by Aum Shimrikyo in 1994 and 1995. More recently, VX was used in the assassination of Mr. Kim Jong-Nam in Kuala Lumpur,
Anthony T. Tu
doaj   +1 more source

Mechanism-based corrector combination restores ΔF508-CFTR folding and function. [PDF]

, 2013
The most common cystic fibrosis mutation, Delta F508 in nucleotide binding domain 1 (NBD1), impairs cystic fibrosis transmembrane conductance regulator (CFTR)-coupled domain folding, plasma membrane expression, function and stability. VX-809, a promising
Okiyoneda, T., Beekman, Jeffrey, Verkman, Alan, Soya, N., Bagdany, Miklos, Dekkers, J. F., Kurth, Mark, Lukacs, Gergely, Veit, G., Veit, Guido, Beekman, Jeffrey M., Hegedűs, Tamás, Soya, Naoto, Bagdany, M., Lukacs, Gergely L., Dekkers, Johanna, Xu, Haijin, Okiyoneda, Tsukasa, Verkman, Alan S., Simon, Ágnes, Roldan, Ariel, Dekkers, Johanna F.   +21 more
core   +1 more source

Valerio Magrelli. Geologia di un padre (fragmenten)

Incontri: Rivista Europea di Studi Italiani, 2017
Vertaling: Emilia ...
Emilia Menkveld
doaj   +1 more source