Results 21 to 30 of about 27,247 (245)
Biomolecules, 2020 In the present work, we performed a complementary quantum mechanical (QM) study to describe the mechanism by which deprotonated pralidoxime (2-PAM) could reactivate human (Homo sapiens sapiens) acetylcholinesterase (HssAChE) inhibited by the nerve agent ...
Jorge Alberto Valle da Silva +5 more
doaj +1 more source
Molecular basis of telaprevir resistance due to V36 and T54 mutations in the NS3-4A protease of the hepatitis C virus [PDF]
, 2008 Background The inhibitor telaprevir (VX-950) of the hepatitis C virus (HCV) protease NS3-4A has been tested in a recent phase 1b clinical trial in patients infected with HCV genotype 1. This trial revealed residue mutations that confer varying degrees of
Stefan Zeuzem +32 more
core +1 more source
The Pulsation Spectrum of VX Hydrae [PDF]
Publications of the Astronomical Society of the Pacific, 2009 14 pages, 5 figures, published in Publications of the Astronomical Society of the Pacific, v.121, p.1076 (October 2009)
Templeton, M. R. +5 more
openaire +2 more sources
Investigation of the Colorimetric Characteristics of VX in Squaraine-Based Solutions
Chemosensors, 2023 Colorimetry is an important on-site detection method for organophosphorus compounds. O-Ethyl S-(2-diisopropylaminoethyl) methylphosphonothioate (VX) is recognized as one of the deadliest organophosphorus chemical agents, and the rapid on-site detection ...
Bin Du +6 more
doaj +1 more source
Drought stress during the reproductive stage of two soybean lines [PDF]
Pesquisa Agropecuária Brasileira, 2020 : The objective of this work was to evaluate the effects of drought stress in the reproductive stage (R3) on the physiological parameters and grain yield of two soybean (Glycine max) lines.
Vanessa do Rosário Rosa +7 more
doaj +2 more sources
VX toxicity in the Göttingen minipig [PDF]
Toxicology Letters, 2016 The present experiments determined the intramuscular LD50 of VX in male Göttingen minipigs at two stages of development. In pubertal animals (115 days old), the LD50 of VX was indeterminate, but approximated 33.3μg/kg. However, in sexually mature animals (152 days old), the LD50 was estimated to be only 17.4μg/kg.
Jeffrey L, Langston, Todd M, Myers
openaire +2 more sources
Counteracting poisoning with chemical warfare nerve agents
Arhiv za Higijenu Rada i Toksikologiju, 2020 Phosphylation of the pivotal enzyme acetylcholinesterase (AChE) by nerve agents (NAs) leads to irreversible inhibition of the enzyme and accumulation of neurotransmitter acetylcholine, which induces cholinergic crisis, that is, overstimulation of ...
Hrvat Nikolina Maček, Kovarik Zrinka
doaj +1 more source
Novel tricyclic pyrrolo-quinolines as pharmacological correctors of the mutant CFTR chloride channel
Scientific Reports, 2023 F508del, the most frequent mutation in cystic fibrosis (CF), impairs the stability and folding of the CFTR chloride channel, thus resulting in intracellular retention and CFTR degradation.
Mario Renda +15 more
doaj +1 more source
Suzetrigine Is Not Expected to Have Clinically Relevant DDIs with Apixaban and Rivaroxaban Based on PBPK Modeling. [PDF]
J Clin PharmacolAbstract Suzetrigine (VX‐548) is a first‐in‐class, oral, non‐opioid, FDA‐approved analgesic for the treatment of moderate to severe acute pain. Based on Phase 1 clinical drug–drug interaction (DDI) studies, suzetrigine is a weak‐to‐moderate cytochrome P450 3A (CYP3A) inducer and thus has the potential to decrease exposure and impact efficacy of CYP3A ...
Wang G +5 more
europepmc +2 more sources
Noot bij de vertaling van Geologia di un padre van Valerio Magrelli
Incontri: Rivista Europea di Studi Italiani, 2017 /
Emilia Menkveld
doaj +1 more source