Results 21 to 30 of about 27,703 (234)

Mechanism-based corrector combination restores ΔF508-CFTR folding and function. [PDF]

, 2013
The most common cystic fibrosis mutation, Delta F508 in nucleotide binding domain 1 (NBD1), impairs cystic fibrosis transmembrane conductance regulator (CFTR)-coupled domain folding, plasma membrane expression, function and stability. VX-809, a promising
Okiyoneda, T., Beekman, Jeffrey, Verkman, Alan, Soya, N., Bagdany, Miklos, Dekkers, J. F., Kurth, Mark, Lukacs, Gergely, Veit, G., Veit, Guido, Hegedűs, Tamás, Soya, Naoto, Bagdany, M., Dekkers, Johanna, Xu, Haijin, Okiyoneda, Tsukasa, Simon, Ágnes, Roldan, Ariel   +17 more
core   +1 more source

VX toxicity in the Göttingen minipig [PDF]

Toxicology Letters, 2016
The present experiments determined the intramuscular LD50 of VX in male Göttingen minipigs at two stages of development. In pubertal animals (115 days old), the LD50 of VX was indeterminate, but approximated 33.3μg/kg. However, in sexually mature animals (152 days old), the LD50 was estimated to be only 17.4μg/kg.
Jeffrey L, Langston, Todd M, Myers
openaire   +2 more sources

Investigation of the Colorimetric Characteristics of VX in Squaraine-Based Solutions

Chemosensors, 2023
Colorimetry is an important on-site detection method for organophosphorus compounds. O-Ethyl S-(2-diisopropylaminoethyl) methylphosphonothioate (VX) is recognized as one of the deadliest organophosphorus chemical agents, and the rapid on-site detection ...
Bin Du, Shu Geng, Wei Cao, Lei Guo, Jianjie Xu, Feng Huang, Lina Chen   +6 more
doaj   +1 more source

Drought stress during the reproductive stage of two soybean lines [PDF]

Pesquisa Agropecuária Brasileira, 2020
: The objective of this work was to evaluate the effects of drought stress in the reproductive stage (R3) on the physiological parameters and grain yield of two soybean (Glycine max) lines.
Vanessa do Rosário Rosa, Adinan Alves da Silva, Danielle Santos Brito, José Domingos Pereira Júnior, Cíntia Oliveira Silva, Maximiller Dal-Bianco, Juraci Alves de Oliveira, Cleberson Ribeiro   +7 more
doaj   +2 more sources

The Pulsation Spectrum of VX Hydrae [PDF]

Publications of the Astronomical Society of the Pacific, 2009
14 pages, 5 figures, published in Publications of the Astronomical Society of the Pacific, v.121, p.1076 (October 2009)
Templeton, M. R., Samolyk, G., Dvorak, S., Poklar, R., Butterworth, N., Gerner, H.   +5 more
openaire   +2 more sources

Counteracting poisoning with chemical warfare nerve agents

Arhiv za Higijenu Rada i Toksikologiju, 2020
Phosphylation of the pivotal enzyme acetylcholinesterase (AChE) by nerve agents (NAs) leads to irreversible inhibition of the enzyme and accumulation of neurotransmitter acetylcholine, which induces cholinergic crisis, that is, overstimulation of ...
Hrvat Nikolina Maček, Kovarik Zrinka
doaj   +1 more source

Novel tricyclic pyrrolo-quinolines as pharmacological correctors of the mutant CFTR chloride channel

Scientific Reports, 2023
F508del, the most frequent mutation in cystic fibrosis (CF), impairs the stability and folding of the CFTR chloride channel, thus resulting in intracellular retention and CFTR degradation.
Mario Renda, Marilia Barreca, Anna Borrelli, Virginia Spanò, Alessandra Montalbano, Maria Valeria Raimondi, Roberta Bivacqua, Ilaria Musante, Paolo Scudieri, Daniela Guidone, Martina Buccirossi, Michele Genovese, Arianna Venturini, Tiziano Bandiera, Paola Barraja, Luis J. V. Galietta   +15 more
doaj   +1 more source

Noot bij de vertaling van Geologia di un padre van Valerio Magrelli

Incontri: Rivista Europea di Studi Italiani, 2017
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Emilia Menkveld
doaj   +1 more source

Molecular modeling studies on the interactions of 7-methoxytacrine-4-pyridinealdoxime, 4-PA, 2-PAM, and obidoxime with VX-inhibited human acetylcholinesterase: a near attack conformation approach

Journal of Enzyme Inhibition and Medicinal Chemistry, 2019
7-methoxytacrine-4-pyridinealdoxime (7-MEOTA-4-PA, named hybrid 5C) is a compound formerly synthesized and evaluated in vitro, together with 4-pyridine aldoxime (4-PA) and commercial reactivators of acetylcholinesterase (AChE). This compound was designed
Jorge Alberto Valle da Silva, Eugenie Nepovimova, Teodorico Castro Ramalho, Kamil Kuca, Tanos Celmar Costa França   +4 more
doaj   +1 more source

Molecular basis of telaprevir resistance due to V36 and T54 mutations in the NS3-4A protease of the hepatitis C virus [PDF]

, 2008
Background The inhibitor telaprevir (VX-950) of the hepatitis C virus (HCV) protease NS3-4A has been tested in a recent phase 1b clinical trial in patients infected with HCV genotype 1. This trial revealed residue mutations that confer varying degrees of
Stefan Zeuzem, Albrecht, M., Hartmann, Christoph, Mayr, G., Andreas Schlicker, Welsch, C., Sarrazin, C., Susser, Simone, Sarrazin, Christoph, Lengauer, T., Albrecht, Mario, Christoph Welsch, Thomas Lengauer, Christoph Sarrazin, Antes, I., Mayr, Gabriele, Iris Antes, Simone Susser, Gabriele Mayr, Lengauer, Thomas, Susser, S., Zeuzem, S., Hartmann, C., Christoph Hartmann, Mario Albrecht, Schlicker, A., Francisco S Domingues, Domingues, Francisco S., Domingues, F., Welsch, Christoph, Schlicker, Andreas, Antes, Iris, Zeuzem, Stefan, Welsch, C.;Domingues, F. S.;Susser, S.;Antes, I.;Hartmann, C.;Mayr, G.;Schlicker, A.;Sarrazin, C.;Albrecht, M.;Zeuzem, S.;Lengauer, T.   +33 more
core   +1 more source