Results 41 to 50 of about 27,703 (234)

Mechanistic Approaches to Improve Correction of the Most Common Disease-Causing Mutation in Cystic Fibrosis.

PLoS ONE, 2016
The most common mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene leads to deletion of the phenylalanine at position 508 (ΔF508) in the CFTR protein and causes multiple folding and functional defects. Contrary to large-scale
Vedrana Bali, Ahmed Lazrak, Purushotham Guroji, Sadis Matalon, Zsuzsanna Bebok   +4 more
doaj   +1 more source

A phase I, randomized, double‐blind, placebo‐controlled, single‐ and multiple dose escalation study evaluating the safety, pharmacokinetics and pharmacodynamics of VX‐128, a highly selective Nav1.8 inhibitor, in healthy adults

Clinical and Translational Science, 2022
Selective inhibition of certain voltage‐gated sodium channels (Navs), such as Nav1.8, is of primary interest for pharmacological pain research and widely studied as a pharmacological target due to its contribution to repetitive firing, neuronal ...
Hemme J. Hijma, Emilie M. J. vanBrummelen, Pieter S. Siebenga, Geert Jan Groeneveld   +3 more
doaj   +1 more source

VX-765 attenuates silica-induced lung inflammatory injury and fibrosis by modulating alveolar macrophages pyroptosis in mice

Ecotoxicology and Environmental Safety, 2023
Silicosis is a diffuse fibrotic lung disease in which excessive inflammatory responses are triggered by silica exposure. Pyroptosis, a pro-inflammatory mode of programmed cell death, is mediated by gasdermin and may play a pivotal role in the development
Huihui Tao, Hui Zhao, Aowei Mo, Luocheng Shao, Deyong Ge, Jiale Liu, Wenjian Hu, Keyi Xu, Qianqian Ma, Wenfeng Wang, Wenyang Wang, Hangbing Cao, Min Mu, Xinrong Tao, Jianhua Wang   +14 more
doaj   +1 more source

Effect of P. aeruginosa on F508del-CFTR Cl secretion in CFBE cells (A) and CF-HBE cells (B) treated with VX-809 alone and VX-809 + VX-770.

, 2015
VX-770 (5 μM) did not significantly alter VX-809 (3 μM) stimulated Cl secretion in CFBE cells. Both PAO1 and PA14 reduced VX-809 + VX-770 stimulated Cl secretion in CFBE cells. By contrast VX-770 significantly reduced VX-809 stimulated Cl secretion in CF-
Bruce A. Stanton (226728), Bonita Coutermarsh (745822), Roxanna Barnaby (745823), Deborah Hogan (745824)   +3 more
core   +1 more source

P38 mitogen activated protein kinase inhibitor improves platelet in vitro parameters and in vivo survival in a SCID mouse model of transfusion for platelets stored at cold or temperature cycled conditions for 14 days.

PLoS ONE, 2021
Platelets for transfusion are stored at room temperature (20-24°C) up to 7 days but decline in biochemical and morphological parameters during storage and can support bacterial proliferation.
Andrey Skripchenko, Monique P Gelderman, Jaroslav G Vostal   +2 more
doaj   +1 more source

Corr-4a reverses the negative effects of VX-770 on VX-809-corrected ΔF508 CFTR half-life.

, 2016
A. I507-ATT ΔF508 CFTR turnover in VX-809 (5μM), VX-809+VX-770 (5μM+5μM) and VX-809+VX-770+Corr-4a (5μM +5μM+10μM) treated cells. B. I507-ATC ΔF508 CFTR turnover in VX-809 (5μM), VX-809+VX-770 (5μM+5μM) and VX-809+VX-770+Corr-4a (5μM +5μM+10μM) treated ...
Purushotham Guroji (2805343), Ahmed Lazrak (613734), Sadis Matalon (613735), Vedrana Bali (2805340), Zsuzsanna Bebok (2657035)   +4 more
core   +1 more source

Vapor Pressure of VX [PDF]

, 1999
Abstract : O-ethyl-S-(diisopropylaminoethly) methyl phosphonothiolate (VX) vapor pressure has been measured using a modified ASTM method in which a carrier gas was slowly passed over the liquid phase, and the saturated effluent was analyzed. Data measured in the current work has extended the low end of the range of measured VX vapor pressures from 30 ...
David E. Tevault, Ann B. Butrow, Leonard C. Buettner, James H. Buchanan   +3 more
openaire   +1 more source

A Holistic Platform Approach for Developing Robust Pulmonary mRNA Delivery: Integrating Novel Phenolic Acid‐Derived Ionizable Lipids and Device Engineering

Advanced Functional Materials, EarlyView.
An integrated pulmonary mRNA delivery platform combining novel biodegradable syringic acid‐derived ionizable lipids, design‐of‐experiments formulation optimization, and vibrating‐mesh nebulizer engineering enabled stable aerosolization and efficient lung delivery.
Neha Kaushal, Younan Ma, Asad Khanmohammed, Dipen Parande, Hanming Zhang, Saket Dolare, Juliet Chen, Apiwat Wangweerawong, Saswata Karmakar, Hongfeng Deng, Frank Koppenhagen, Shraddha Sharma, Eric Reyes, Sherry He, Lianne Boeglin, Caroline Woo, Azadeh Paksa, Ayed Allawzi, Anusha Dias, Gregory Troiano, Shrirang Karve, Frank DeRosa   +21 more
wiley   +1 more source

VX hydrolysis by human serum paraoxonase 1: a comparison of experimental and computational results.

PLoS ONE, 2011
Human Serum paraoxonase 1 (HuPON1) is an enzyme that has been shown to hydrolyze a variety of chemicals including the nerve agent VX. While wildtype HuPON1 does not exhibit sufficient activity against VX to be used as an in vivo countermeasure, it has ...
Matthew W Peterson, Steven Z Fairchild, Tamara C Otto, Mojdeh Mohtashemi, Douglas M Cerasoli, Wenling E Chang   +5 more
doaj   +1 more source

Restoration of R117H CFTR folding and function in human airway cells through combination treatment with VX-809 and VX-770 [PDF]

, 2016
Cystic fibrosis (CF) is a lethal recessive genetic disease caused primarily by the F508del mutation in the CF transmembrane conductance regulator (CFTR). The potentiator VX-770 was the first CFTR modulator approved by the FDA for treatment of CF patients
Gentzsch, Martina, Chaudhry, Imron G., Cholon, Deborah M., Ren, Hong Y., Dokholyan, Nikolay V., Das, Jhuma, Cyr, Douglas M., Quinney, Nancy L., Randell, Scott H., Houck, Scott A., Sopha, Pattarawut   +10 more
core   +1 more source