Results 41 to 50 of about 27,247 (245)

VX-765 attenuates silica-induced lung inflammatory injury and fibrosis by modulating alveolar macrophages pyroptosis in mice

Ecotoxicology and Environmental Safety, 2023
Silicosis is a diffuse fibrotic lung disease in which excessive inflammatory responses are triggered by silica exposure. Pyroptosis, a pro-inflammatory mode of programmed cell death, is mediated by gasdermin and may play a pivotal role in the development
Huihui Tao, Hui Zhao, Aowei Mo, Luocheng Shao, Deyong Ge, Jiale Liu, Wenjian Hu, Keyi Xu, Qianqian Ma, Wenfeng Wang, Wenyang Wang, Hangbing Cao, Min Mu, Xinrong Tao, Jianhua Wang   +14 more
doaj   +1 more source

P38 mitogen activated protein kinase inhibitor improves platelet in vitro parameters and in vivo survival in a SCID mouse model of transfusion for platelets stored at cold or temperature cycled conditions for 14 days.

PLoS ONE, 2021
Platelets for transfusion are stored at room temperature (20-24°C) up to 7 days but decline in biochemical and morphological parameters during storage and can support bacterial proliferation.
Andrey Skripchenko, Monique P Gelderman, Jaroslav G Vostal   +2 more
doaj   +1 more source

Restoration of R117H CFTR folding and function in human airway cells through combination treatment with VX-809 and VX-770 [PDF]

, 2016
Cystic fibrosis (CF) is a lethal recessive genetic disease caused primarily by the F508del mutation in the CF transmembrane conductance regulator (CFTR). The potentiator VX-770 was the first CFTR modulator approved by the FDA for treatment of CF patients
Gentzsch, Martina, Chaudhry, Imron G., Cholon, Deborah M., Ren, Hong Y., Dokholyan, Nikolay V., Das, Jhuma, Cyr, Douglas M., Quinney, Nancy L., Randell, Scott H., Houck, Scott A., Sopha, Pattarawut   +10 more
core   +1 more source

A Holistic Platform Approach for Developing Robust Pulmonary mRNA Delivery: Integrating Novel Phenolic Acid‐Derived Ionizable Lipids and Device Engineering

Advanced Functional Materials, EarlyView.
An integrated pulmonary mRNA delivery platform combining novel biodegradable syringic acid‐derived ionizable lipids, design‐of‐experiments formulation optimization, and vibrating‐mesh nebulizer engineering enabled stable aerosolization and efficient lung delivery.
Neha Kaushal, Younan Ma, Asad Khanmohammed, Dipen Parande, Hanming Zhang, Saket Dolare, Juliet Chen, Apiwat Wangweerawong, Saswata Karmakar, Hongfeng Deng, Frank Koppenhagen, Shraddha Sharma, Eric Reyes, Sherry He, Lianne Boeglin, Caroline Woo, Azadeh Paksa, Ayed Allawzi, Anusha Dias, Gregory Troiano, Shrirang Karve, Frank DeRosa   +21 more
wiley   +1 more source

VX hydrolysis by human serum paraoxonase 1: a comparison of experimental and computational results.

PLoS ONE, 2011
Human Serum paraoxonase 1 (HuPON1) is an enzyme that has been shown to hydrolyze a variety of chemicals including the nerve agent VX. While wildtype HuPON1 does not exhibit sufficient activity against VX to be used as an in vivo countermeasure, it has ...
Matthew W Peterson, Steven Z Fairchild, Tamara C Otto, Mojdeh Mohtashemi, Douglas M Cerasoli, Wenling E Chang   +5 more
doaj   +1 more source

Photocatalytic oxidation of VX-simulation substance

Water Science and Technology, 2007
Experimental studies of photocatalytic oxidation (PCO) of VX-gas simulation substance cysteamine-S-phosphate sodium salt (NaHPO3S–CH2–CH2–NH2, CPSS) at various initial concentrations and pH were undertaken. PCO ultimately resulted in complete mineralisation of CPSS.
Lyon, Celine, Rima, G., Kozlova, E., Vorontsov, A., Preis, S.   +4 more
openaire   +3 more sources

Corr-4a diminishes negative effects of VX-770 on VX-809-rescued I507-ATT ΔF508 CFTR.

, 2016
A. Mechanism of action of CFTR modulators used in our studies. B. Western blot analysis of I507-ATT and I507-ATC ΔF508 CFTR expressing HEK-293 cell lysates following vehicle control (0.15% DMSO, 16 h, 37°C) or corrector treatment (5μM VX-809, 5μM VX-770 ...
Purushotham Guroji (2805343), Ahmed Lazrak (613734), Sadis Matalon (613735), Vedrana Bali (2805340), Zsuzsanna Bebok (2657035)   +4 more
core   +1 more source

Wireless Precise Manipulation of Tumor Spheroids Using a Millirobot Controlled by Permanent Magnetic Traps

Advanced Robotics Research, EarlyView.
A magnetic donut‐like millirobot is developed for label‐free pick‐and‐place of a tumor spheroid wirelessly controlled by a magnetic trap. Spheroids are important 3D multicellular culture systems that recapitulate key structural and functional features of native tissues.
Yue Gao, Moonkwang Jeong, Anni G. Muñoz, Ann‐Sophia Müller, Fangchao Long, Shengqiang Zhou, Juntian Qu, Leoni A. Kunz‐Schughart, Tian Qiu   +8 more
wiley   +1 more source

The Procoagulant Snake Venom Serine Protease Potentially Having a Dual, Blood Coagulation Factor V and X-Activating Activity

Toxins, 2020
A procoagulant snake venom serine protease was isolated from the venom of the nose-horned viper (Vipera ammodytes ammodytes). This 34 kDa glycoprotein, termed VaaSP-VX, possesses five kDa N-linked carbohydrates.
Zorica Latinović, Adrijana Leonardi, Cho Yeow Koh, R. Manjunatha Kini, Alenka Trampuš Bakija, Jože Pungerčar, Igor Križaj   +6 more
doaj   +1 more source

Ion Chemistry of VX Surrogates and Ion Energetics Properties of VX: New Suggestions for VX Chemical Ionization Mass Spectrometry Detection

, 2016
Room temperature rate constants and product ion branching ratios have been measured for the reactions of numerous positive and negative ions with VX chemical warfare agent surrogates representing the amine (triethylamine) and organophosphonate (diethyl ...
Satoshi Maeda (1247163), Thomas M. Miller (2302165), Narayan C. Bera (2144899), Anthony J. Midey (2302168), A. A. Viggiano (1277079), Keiji Morokuma (1247166)   +5 more
core   +1 more source