Results 31 to 40 of about 243,296 (232)

Lymphocyte Antigen 6G Mediates Vagotomy-Associated Reduction in Body Weight. [PDF]

open access: yesFASEB J
Vagotomy was associated with lower body weight and epididymal white adipose tissue (eWAT) mass, as well as increased Ly6G+ cell infiltration in eWAT. This vagotomy‐associated weight loss was significantly attenuated in neutrophil‐deficient mice, suggesting Ly6G+ cells participate in the regulation of eWAT energy homeostasis.
Liu T   +18 more
europepmc   +2 more sources

Identification of binding sites for ivacaftor on the cystic fibrosis transmembrane conductance regulator

open access: yesiScience, 2021
Summary: Ivacaftor (VX-770) was the first cystic fibrosis transmembrane conductance regulator (CFTR) modulatory drug approved for the treatment of patients with cystic fibrosis.
Onofrio Laselva   +10 more
doaj   +1 more source

Reducing C-terminal truncation mitigates synucleinopathy and neurodegeneration in a transgenic model of multiple system atrophy [PDF]

open access: yes, 2016
Multiple system atrophy (MSA) is a sporadic orphan neurodegenerative disorder. No treatment is currently available to slow down the aggressive neurodegenerative process, and patients die within a few years after disease onset.
Bassil, Fares   +8 more
core   +3 more sources

The Caspase 1 Inhibitor VX-765 Protects the Isolated Rat Heart via the RISK Pathway [PDF]

open access: yes, 2018
PURPOSE: Protecting the heart from ischaemia-reperfusion (IR) injury is a major goal in patients presenting with an acute myocardial infarction. Pyroptosis is a novel form of cell death in which caspase 1 is activated and cleaves interleukin 1β.
Arjun, S   +4 more
core   +1 more source

Do environmental quality standards for selected nerve agents ensure safety of the ecosystems? / Czy istniejące standardy jakości środowiska dla wybranych fosforoorganicznych bojowych środków trujących zapewniają również ochronę ekosystemów?

open access: yesEnvironmental Protection and Natural Resources, 2013
Zagrożenie i ryzyko powodowane fosforoorganicznymi bojowymi środkami trującymi w stosunku do ludzi i organizmów wyższych jest stosunkowo dobrze rozpoznane i zbadane, jednakże dane naukowe dotyczące środowiskowego oddziaływania tego typu substancji są ...
Kalinowski Radosław   +2 more
doaj   +1 more source

Biochemical properties of a novel cysteine protease of Plasmodium vivax, vivapain-4. [PDF]

open access: yesPLoS Neglected Tropical Diseases, 2010
Multiple cysteine proteases of malaria parasites are required for maintenance of parasite metabolic homeostasis and egress from the host erythrocyte. In Plasmodium falciparum these proteases appear to mediate the processing of hemoglobin and aspartic ...
Byoung-Kuk Na   +10 more
doaj   +1 more source

Application of 3D scanning technology in Royal Malaysian Air Force Industrial Revolution 4.0‐based aircraft maintenance

open access: yesIET Networks, EarlyView., 2022
Abstract 3D scanning is rapidly becoming a key maintenance tool. Aerospace was a pioneer in adopting 3D scanning technology because aircraft manufacture and maintenance require precision. Monitoring deterioration, removing components for maintenance, and verifying covert operations are not practical or helpful without technology.
T. Nanthakumaran Thulasy   +4 more
wiley   +1 more source

Biomechanical comparison of the track start and the modified one-handed track start in competitive swimming: an intervention study [PDF]

open access: yes, 2008
This study compared the conventional track and a new one-handed track start in elite age group swimmers to determine if the new technique had biomechanical implications on dive performance.
Galbraith, H   +4 more
core   +1 more source

Molecular modeling studies on the interactions of 7-methoxytacrine-4-pyridinealdoxime, 4-PA, 2-PAM, and obidoxime with VX-inhibited human acetylcholinesterase: a near attack conformation approach

open access: yesJournal of Enzyme Inhibition and Medicinal Chemistry, 2019
7-methoxytacrine-4-pyridinealdoxime (7-MEOTA-4-PA, named hybrid 5C) is a compound formerly synthesized and evaluated in vitro, together with 4-pyridine aldoxime (4-PA) and commercial reactivators of acetylcholinesterase (AChE). This compound was designed
Jorge Alberto Valle da Silva   +4 more
doaj   +1 more source

Multiple Scattering Theory for the Photoproduction of Vector Mesons off Nuclei [PDF]

open access: yes, 1996
The integrated cross section for the incoherent photoproduction of vector mesons on nuclei $\gamma^* A \to VX$, $X\not=A$, is calculated within Glauber theory and as a function of the photon energy.
Bauer   +8 more
core   +2 more sources

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