Results 31 to 40 of about 24,286 (193)
Chemistry – A European Journal, EarlyView.ABSTRACT The development of synthetic procedures for preparing metal nanoparticles with controlled size using sunlight opens new avenues toward more sustainable methods with lower energy consumption. Herein, we propose the use of double‐vacancy halide perovskites as precursors for engineering highly crystalline and small platinum nanoparticles (< 3 nm)
Kevin Mego +4 more
wiley +1 more source
, 2015 VX-770 (5 μM) did not significantly alter VX-809 (3 μM) stimulated Cl secretion in CFBE cells. Both PAO1 and PA14 reduced VX-809 + VX-770 stimulated Cl secretion in CFBE cells. By contrast VX-770 significantly reduced VX-809 stimulated Cl secretion in CF-
Bruce A. Stanton (226728) +3 more
core +1 more source
Repurposing Drugs for Malaria through a Human Dose Prediction: A Case Study with Berzosertib
Clinical Pharmacology &Therapeutics, EarlyView.Repurposing drugs whose clinical safety has been established offers a valuable approach to reduce the cost and time associated with the development of new drugs for malaria. Here, we investigate the potential to repurpose the anticancer kinase inhibitor berzosertib for the treatment of malaria, by assessing whether a predicted efficacious human dose ...
Devasha Redhi +5 more
wiley +1 more source
, 2009 The alkaline perhydrolysis of the nerve agent O-ethyl S-[2-(diisopropylamino)ethyl] methylphosphonothioate (VX) was investigated by studying the ion-molecule reactions of HOO(-) with O,S-dimethyl methylphosphonothioate in a modified linear ion-trap mass ...
Williams, J. +4 more
core +1 more source
Acoustic‐driven surface cleaning with millimeter‐sized bubbles at translational resonance
Droplet, EarlyView.Time‐lapse visualization comparing bubble trajectories. The top panel (0 Hz) shows a bubble's linear path under no acoustic forcing, while the bottom panel (50 Hz) demonstrates the oscillatory motion induced by acoustic waves at a resonance mode. This mechanism holds promising potential for applications such as surface cleaning.
Yan Jun Lin +2 more
wiley +1 more source
, 2016 Cystic fibrosis (CF) is a lethal recessive genetic disease caused primarily by the F508del mutation in the CF transmembrane conductance regulator (CFTR). The potentiator VX-770 was the first CFTR modulator approved by the FDA for treatment of CF patients
Gentzsch, Martina +10 more
core +1 more source
Deep Underground Science and Engineering, EarlyView.Fluid flow through a single fracture is commonly described by the cubic law. However, deviations from this model are expected because natural fracture surfaces are rough and in contact with each other in discrete regions. In this study, the interactions between fracture closure, contact area, and hydraulic characterization of mesoscopic‐scale rough ...
Chenghao Han +5 more
wiley +1 more source
Epilepsia, EarlyView.Abstract Understanding the mechanisms underlying post‐traumatic epilepsy (PTE) following traumatic brain injury (TBI), and developing strategies to prevent or modify its progression, has been the focus of large collaborative efforts within the epilepsy and TBI research communities for over a decade.
Elisa R. Zanier +82 more
wiley +1 more source
Effects of the Aurora kinase inhibitor VX-680 on anaplastic thyroid cancer-derived cell lines.
, 2008 International audienceAnaplastic thyroid cancers (ATC) are aggressive tumors, which exhibit cell cycle misregulations leading to uncontrolled cellular proliferation and genomic instability.
Delcros, Jean-Guy +8 more
core +3 more sources
The multiple hit model of infantile and epileptic spasms: The 2025 update
Epilepsia Open, EarlyView.Abstract Objective Infantile and epileptic spasms syndrome (IESS) is a developmental and epileptic encephalopathy manifesting with epileptic spasms and poor neurodevelopmental outcomes. There is an urgent need for the development of more effective and tolerated therapies.
Aristea S. Galanopoulou +6 more
wiley +1 more source