Results 31 to 40 of about 27,703 (234)

Some gating potentiators, including VX-770, diminish ΔF508-CFTR functional expression. [PDF]

, 2014
Cystic fibrosis (CF) is caused by mutations in the CF transmembrane regulator (CFTR) that result in reduced anion conductance at the apical membrane of secretory epithelia.
Apaja, Pirjo M., Bagdany, Miklos, Phuan, Puay-Wah, Avramescu, Radu G., Hegedus, Tamas, Wu, Yu-Sheng, Veit, Guido, Borot, Florence, Lukacs, Gergely L., Perdomo, Doranda, Szollosi, Daniel, Finkbeiner, Walter E., Verkman, Alan S.   +12 more
core   +3 more sources

Do environmental quality standards for selected nerve agents ensure safety of the ecosystems? / Czy istniejące standardy jakości środowiska dla wybranych fosforoorganicznych bojowych środków trujących zapewniają również ochronę ekosystemów?

Environmental Protection and Natural Resources, 2013
Zagrożenie i ryzyko powodowane fosforoorganicznymi bojowymi środkami trującymi w stosunku do ludzi i organizmów wyższych jest stosunkowo dobrze rozpoznane i zbadane, jednakże dane naukowe dotyczące środowiskowego oddziaływania tego typu substancji są ...
Kalinowski Radosław, Chrzanowska Edyta, Brytan Marek   +2 more
doaj   +1 more source

Identification of binding sites for ivacaftor on the cystic fibrosis transmembrane conductance regulator

iScience, 2021
Summary: Ivacaftor (VX-770) was the first cystic fibrosis transmembrane conductance regulator (CFTR) modulatory drug approved for the treatment of patients with cystic fibrosis.
Onofrio Laselva, Zafar Qureshi, Zhi-Wei Zeng, Evgeniy V. Petrotchenko, Mohabir Ramjeesingh, C. Michael Hamilton, Ling-Jun Huan, Christoph H. Borchers, Régis Pomès, Robert Young, Christine E. Bear   +10 more
doaj   +1 more source

Concurrent validity and reliability of a low-cost gait analysis system for assessment of spatiotemporal gait parameters

Journal of Rehabilitation Medicine, 2019
Objective: To determine the concurrent validity and reliability of a low-cost spatiotemporal gait analysis system for clinical use in rehabilitation medicine. Design: Cross-sectional study. Subjects: Thirty-three healthy adults.
Maijke van Bloemendaal, Anita Beelen, Rob F.M. Kleissen, Alexander C. Geurts, Frans Nollet, Sicco A. Bus   +5 more
doaj   +1 more source

Biochemical properties of a novel cysteine protease of Plasmodium vivax, vivapain-4. [PDF]

PLoS Neglected Tropical Diseases, 2010
Multiple cysteine proteases of malaria parasites are required for maintenance of parasite metabolic homeostasis and egress from the host erythrocyte. In Plasmodium falciparum these proteases appear to mediate the processing of hemoglobin and aspartic ...
Byoung-Kuk Na, Young-An Bae, Young-Gun Zo, Youngchool Choe, Seon-Hee Kim, Prashant V Desai, Mitchell A Avery, Charles S Craik, Tong-Soo Kim, Philip J Rosenthal, Yoon Kong   +10 more
doaj   +1 more source

Application of 3D scanning technology in Royal Malaysian Air Force Industrial Revolution 4.0‐based aircraft maintenance

IET Networks, EarlyView., 2022
Abstract 3D scanning is rapidly becoming a key maintenance tool. Aerospace was a pioneer in adopting 3D scanning technology because aircraft manufacture and maintenance require precision. Monitoring deterioration, removing components for maintenance, and verifying covert operations are not practical or helpful without technology.
T. Nanthakumaran Thulasy, Puteri N. E. Nohuddin, Istas Fahrurrazi Nusyirwan, Mohd Hanafi Ahmad Hijazi, Musaddak Maher Abdul Zahra   +4 more
wiley   +1 more source

Vaccination with staphylococcal protein A protects mice against systemic complications of skin infection recurrences

Frontiers in Immunology
Skin and soft tissue infections (SSTIs) are the most common diseases caused by Staphylococcus aureus (S. aureus), which can progress to threatening conditions due to recurrences and systemic complications.
Andrea Paola Mandelli, Greta Magri, Marco Tortoli, Stefania Torricelli, Donatello Laera, Fabio Bagnoli, Oretta Finco, Giuliano Bensi, Michela Brazzoli, Emiliano Chiarot   +9 more
doaj   +1 more source

Nerve agents: A clear and present danger to mankind [PDF]

Scripta Medica, 2019
This editorial is written on the occasion of the 25th anniversary of the infamous sarin and VX terrorist attacks in Japan, in order to increase the awareness of the potential terrorist use of nerve agents and to urge the preparedness to cope with its ...
Stojiljković Miloš P.
doaj  

Corr-4a diminishes negative effects of VX-770 on VX-809-rescued I507-ATT ΔF508 CFTR.

, 2016
A. Mechanism of action of CFTR modulators used in our studies. B. Western blot analysis of I507-ATT and I507-ATC ΔF508 CFTR expressing HEK-293 cell lysates following vehicle control (0.15% DMSO, 16 h, 37°C) or corrector treatment (5μM VX-809, 5μM VX-770 ...
Purushotham Guroji (2805343), Ahmed Lazrak (613734), Sadis Matalon (613735), Vedrana Bali (2805340), Zsuzsanna Bebok (2657035)   +4 more
core   +1 more source

Corr-4a increases cAMP-activated, CFTR_inh-172-inhibited whole-cell currents in VX-809+VX-770 treated I507-ATT ΔF508 CFTR expressing cells.

, 2016
Whole-cell patch clamp studies were performed following treatment with CFTR modulators as specified (5μM VX-809 + 10μM Corr-4a+ 5μM VX-770, 16h, 37°C). Corr-4a and VX-809 were present during recordings, but VX-770 was washed out prior to experiments.
Purushotham Guroji (2805343), Ahmed Lazrak (613734), Sadis Matalon (613735), Vedrana Bali (2805340), Zsuzsanna Bebok (2657035)   +4 more
core   +1 more source