Results 51 to 60 of about 674 (166)

Mechanism of reactivation by V146H/L363E hCE1 after cyclosarin binding.

, 2013
A. Model of V146H/L363E (cyan) hCE1 with PR cyclosarin (magenta) including a water molecule (red) between E363 and the central phosphorus. B. Proposed mechanism for enhanced reactivation following cyclosarin inhibition. C.
Steven L. Lewis (354519), Matthew R. Redinbo (93591), Carol C. Edwards (354521), Tamara C. Otto (350617), Philip M. Potter (23125), Douglas M. Cerasoli (350618), C. Linn Cadieux (354524), John R. Cashman (354526), Lyudmila Tsurkan (354523), Shane A. Kasten (354525), Roberto A. Chica (109101), Stephen L. Mayo (109096), Monika Wierdl (354512), Jonathan S. Edwards (354516), Andrew C. Hemmert (354510)   +14 more
core   +1 more source

Bimolecular rates of inhibition, Michaelis-Menten constants, and rates of reactivation for wild-type and V146H/L363E hCE1 against racemic cyclosarin and stereoisomers of cyclosarin model compounds.

, 2013
N = 3, s.d., N.D. is not determined, N.R. is no reactivation, pH 7.4, 25°C.aRacemic bona fide cyclosarin,bstereoisomers of cyclosarin model compounds,c(8).
Steven L. Lewis (354519), Matthew R. Redinbo (93591), Carol C. Edwards (354521), Tamara C. Otto (350617), Philip M. Potter (23125), Douglas M. Cerasoli (350618), C. Linn Cadieux (354524), John R. Cashman (354526), Lyudmila Tsurkan (354523), Shane A. Kasten (354525), Roberto A. Chica (109101), Stephen L. Mayo (109096), Monika Wierdl (354512), Jonathan S. Edwards (354516), Andrew C. Hemmert (354510)   +14 more
core   +1 more source

Substituted Monoquaternary Oximes as Reactivators of Cyclosarin- and Chlorpyrifos-Inhibited Acetylcholinesterase [PDF]

, 2006
U ovome in vitro istraživanju testiran je reaktivacijski potencijal triju reaktivatora acetilkolinesteraze (AChE; EC 3.1.1.7) dobivenih iz monokvaternog reaktivatora pralidoksima.
Martina Hrabinova, Jun, Daniel, Kamil Kuča, Daniel Jun, Veronika Racakova, Racakova, Veronika, Hrabinova, Martina, Kuča, Kamil   +7 more
core   +1 more source

Modified Biosensor for Cholinesterase Inhibitors with Guinea Green B as the Color Indicator

Biosensors, 2018
Colorimetric biosensors of cholinesterase inhibitors are ideal for fast, reliable, and very simple detection of agents in air, in water, and on surfaces.
Vladimír Pitschmann, Lukáš Matějovský, Martin Lobotka, Jan Dědič, Martin Urban, Michal Dymák   +5 more
doaj   +1 more source

Effects of low-level sarin and cyclosarin exposure on white matter integrity in Gulf War Veterans [PDF]

NeuroToxicology, 2015
We previously found evidence of reduced gray and white matter volume in Gulf War (GW) veterans with predicted low-level exposure to sarin (GB) and cyclosarin (GF). Because loss of white matter tissue integrity has been linked to both gray and white matter atrophy, the current study sought to test the hypothesis that GW veterans with predicted GB/GF ...
Linda L, Chao, Yu, Zhang, Shannon, Buckley   +2 more
openaire   +2 more sources

Green Computational Approach for Raman Spectroscopy Prediction: A Sustainable Method for Hazardous Chemical Database Construction

Chemistry–Methods, Volume 6, Issue 7, July 2026.
A green density functional theory‐based Raman prediction workflow is presented as a safe alternative to hazardous experimental characterization. The optimized computational model enables accurate spectral prediction, scalable database expansion, and structural differentiation using key P═O, C═N, and P–F Raman markers while minimizing waste and ...
Honghyun Kim, Yoonjae Cho, Tae In Ryu, Keunhong Jeong   +3 more
wiley   +1 more source

Therapeutic Efficacy of Different Antidotal Mixtures Against Poisoning with GF-Agent in Mice

Acta Medica, 2004
The toxicity of cyclohexyl methylphosphonofluoridate (GF-agent; cyclosarin) and therapeutic efficacy of four oximes (trimedoxime, methoxime, obidoxime and HI-6) in combination with atropine or benactyzine (BNZ) was studied in mice.
Lucie Bartošová, Gabriela Kunešová, Kamil Kuča, Josef Vachek   +3 more
doaj   +1 more source

Micro/nanorobots for detecting and eliminating biological and chemical warfare agents

BMEMat, Volume 4, Issue 1, March 2026.
Fuel‐powered and field‐driven micro/nanorobots provide a cutting‐edge platform to safeguard national security and defense. This review reports the latest research progress in micro/nanorobots in sensing and detoxifying biological and chemical warfare agents.
Song Li, Huaijuan Zhou, Di Shi, Zdeněk Sofer, Jinhua Li   +4 more
wiley   +1 more source

Toxicological analyses of the bone matrix: Successes and challenges

Archaeometry, Volume 67, Issue 4, Page 1001-1021, August 2025.
Abstract This study aimed to conduct an in‐depth and systematic literature review dealing with toxicological analyses on human bone tissue and focusing on the forensic toxicological and archaeotoxicological field. Several studies have focused their research on medical drugs, drugs of abuse, and trace elements on both human cadavers and skeletal remains,
Gaia Giordano, Lucie Biehler‐Gomez, Cristina Cattaneo, Domenico Di Candia   +3 more
wiley   +1 more source

A Thermostable Bacterial Metallohydrolase that Degrades Organophosphate Plasticizers

ChemBioChem, Volume 26, Issue 11, June 3, 2025.
This bacterial enzyme, cyclase‐phosphotriesterase (C‐PTE) from Ruegeria pomeroyi DSS‐3, shows significant potential for breaking down organophosphate pollutants. Beyond its capability to hydrolyze specific plasticizers such as triphenyl phosphate and tris(2‐chloropropyl) phosphate, C‐PTE's crystal structure reveals a binuclear zinc active site, and it ...
Dawei Ji, Rebecca L. Frkic, Javad Delyami, Joachim S. Larsen, Matthew A. Spence, Colin J. Jackson   +5 more
wiley   +1 more source