Results 31 to 40 of about 1,056 (182)

Chemical Weapons in the Iran-Iraq War (1980-1988) Iraq Preparing for Chemical War

Вестник войск РХБ защиты, 2023
The Iraqis became the first nation to use chemical weapons on the modern battlefield during the IranIraq War (1980-1988). There are no general reviews and research available on this issue in Russian.
M. V. Supotnitskiy, N. I. Shilo, V. A. Kovtun   +2 more
doaj   +1 more source

Direct reaction of oximes with crotylsarin, cyclosarin, or VX in vitro [PDF]

Archives of Toxicology, 2006
The direct reaction of seven pyridinium oximes with the organophosphorus compounds (OPCs) crotylsarin, cyclosarin, and VX was studied by spectrophotometry. This method allows to quantify different parameters: (a) the half-life times (t (1/2)) of the oxime-OPC reactions on the basis of the changes in the absorption at the zwitterion (betaine) peak ...
Becker, G., Kawan, A., Gutzeit, D., Worek, F., Szinicz, L.   +4 more
openaire   +2 more sources

Chemical Weapons in the Iran-Iraq War (1980–1988). 2. Combat Use of Chemical Weapons

Вестник войск РХБ защиты, 2023
The Iran-Iraq war (1980–1988) was the result of the geopolitical situation in the Middle East after the Islamic revolution in Iran in 1979. Certain longstanding territorial disputes and the absence of mutually recognized state border between the rivalry ...
M. V. Supotnitskiy, N. I. Shilo, V. A. Kovtun   +2 more
doaj   +1 more source

Molecular aspects of the reactivation process of acetylcholinesterase inhibited by cyclosarin [PDF]

Journal of the Brazilian Chemical Society, 2011
®® para avaliar as constantes cineticas de associacao e reativacao de oximas, em relacao a resultados in vitro previamente reportados na literatura. Como observado antes, os resultados mostraram boa correlacao entre as energias livres teoricas de ligacao das oximas e os dados experimentais, corroborando a metodologia como adequada para a predicao de ...
Matos, Karina S., Mancini, Daiana T., Cunha, Elaine F. F. da, Kuča, Kamil, França, Tanos C. C., Ramalho, Teodorico C.   +5 more
openaire   +3 more sources

Phosphonylated tyrosine and lysine residues as biomarkers of local exposure of human hair to the organophosphorus nerve agents sarin and VX

Drug Testing and Analysis, Volume 15, Issue 7, Page 730-744, July 2023., 2023
This is the first report addressing analysis of biomarker adducts obtained from human hair exposed to the nerve agents sarin and VX in vitro. Phosphonylated single amino acids were obtained after pronase‐catalyzed proteolysis of hair proteins. Adducted Lys and especially Tyr residues were the most prominent adducts detected by μLC‐ESI MS/HR MS.
Harald John, Tamara Lindl, Henrik Reuter, Wolfgang Schmeißer, Michael Schrader, Horst Thiermann   +5 more
wiley   +1 more source

Sex‐based structural and functional MRI outcomes in the rat brain after soman (GD) exposure‐induced status epilepticus

Epilepsia Open, Volume 8, Issue 2, Page 399-410, June 2023., 2023
Abstract Objective Exposure to the nerve agent, soman (GD), induces status epilepticus (SE), epileptogenesis, and even death. Although rodent models studying the pathophysiological mechanisms show females to be more reactive to soman, no tangible sex differences in brains postexposure have been reported.
Meghan Gage, Suraj S Vasanthi, Christina M Meyer, Nikhil S Rao, Daniel R Thedens, Sridhar S. Kannurpatti, Thimmasettappa Thippeswamy   +6 more
wiley   +1 more source

Dysbiosis in gastrointestinal pathophysiology: Role of the gut microbiome in Gulf War Illness

Journal of Cellular and Molecular Medicine, Volume 27, Issue 7, Page 891-905, April 2023., 2023
Abstract Gulf War Illness (GWI) has been reported in 25%–35% of veterans returned from the Gulf war. Symptoms of GWI are varied and include both neurological and gastrointestinal symptoms as well as chronic fatigue. Development of GWI has been associated with chemical exposure particularly with exposure to pyridostigmine bromide (PB) and permethrin ...
Elise Slevin, Sachiko Koyama, Kelly Harrison, Ying Wan, James E. Klaunig, Chaodong Wu, Ashok K. Shetty, Fanyin Meng   +7 more
wiley   +1 more source

EFFECTIVITY OF NEW ACETYLCHOLINESTERASE REACTIVATORS IN TREATMENT OF CYCLOSARIN POISONING IN MICE AND RATS [PDF]

Biomedical Papers, 2005
The present study was performed to assess and compare a therapeutic efficacy of obidoxime, HI-6, BI-6 and HS-6 administered in equimolar doses and combined with atropine in cyclosarin-poisoned mice and rats. It was demonstrated that all the therapeutic regimens tested, were able to decrease the cyclosarin-induced toxicity significantly - at least 1.5 ...
Lucie, Bartosová, Kamil, Kuca, Gabriela, Kunesová   +2 more
openaire   +2 more sources

Reactivation Potency of New Group of Acetylcholinesterase Reactivators and Their Comparison with Currently Available Oximes

Acta Medica, 2006
In this work, in vitro potency of novel serie of monoquaternary pyridinium oximes to reactivate cyclosarin-inhibited acetylcholinesterase (AChE) was tested.
Kamil Kuča, Jan Pícha, Daniel Jun
doaj   +1 more source

Aminoalkoxy‐substituted coumarins: Synthesis and evaluation for reactivation of inhibited human acetylcholinesterase

Archiv der Pharmazie, Volume 355, Issue 11, November 2022., 2022
Significant effort has been invested into the development of cholinesterase reactivators that are capable of treating organophosphorus poisoning. A series of 12 coumarin derivatives equipped with linker‐connected nonaromatic terminal amino moieties were prepared in this study.
Paul W. Elsinghorst, Timo Wille, Danijela Barić, Matthias D. Mertens, Madlen Baumann, Jim Küppers, Michael Gütschow   +6 more
wiley   +1 more source