Results 31 to 40 of about 687 (168)

Substrate Analogues for the Enzyme-Catalyzed Detoxification of the Organophosphate Nerve Agents—Sarin, Soman, and Cyclosarin

Biochemistry, 2021
The G-type nerve agents, sarin (GB), soman (GD), and cyclosarin (GF), are among the most toxic compounds known. Much progress has been made in evolving the enzyme phosphotriesterase (PTE) from Pseudomonas diminuta for the decontamination of the G-agents; however, the extreme toxicity of the G-agents makes the use of substrate analogues necessary ...
Andrew N. Bigley, Steven P. Harvey, Tamari Narindoshvili, Frank M. Raushel   +3 more
openaire   +3 more sources

In Vitro Interaction of Organophosphono- and Organophosphorothioates with Human Acetylcholinesterase [PDF]

Molecules, 2020
The implementation of the Chemical Weapons Convention (CWC) in 1997 was a milestone in the prohibition of chemical warfare agents (CWA). Yet, the repeated use of CWA underlines the ongoing threat to the population.
Franz Worek, Horst Thiermann, Marianne Koller, Timo Wille   +3 more
doaj   +2 more sources

Mechanistic studies of new oximes reactivators of human butyryl cholinesterase inhibited by cyclosarin and sarin

Journal of Biomolecular Structure and Dynamics, 2016
Butyryl cholinesterase (BChE) has been seen as a key enzyme in the search for new strategies in the treatment of poisoning by organophosphates (OPs), since human BChE (HssBChE), complexed with the appropriate oxime, can be a suitable scavenger and deactivator for OPs in the blood stream.
Lima, Willian E. Amaral de, Francisco, Ander, Cunha, Elaine Fontes Ferreira da, Radic, Zoran, Taylor, Palmer, França, Tanos C. C., Ramalho, Teodorico C.   +6 more
openaire   +3 more sources

Detection of Chemical Weapon Agents Using Spectroscopic Probes: A Computational Study

Journal of Chemistry, 2020
Organophosphorus compounds are organic compounds widely employed in agriculture as well as in chemical weapons. The use in agriculture is due to their insecticidal properties.
Letícia S. Braga, Érika F. Silva, Daiana T. Mancini, Eduardo P. da Rocha, Elaine F. F. da Cunha, Teodorico C. Ramalho   +5 more
doaj   +2 more sources

Modified Biosensor for Cholinesterase Inhibitors with Guinea Green B as the Color Indicator

Biosensors, 2018
Colorimetric biosensors of cholinesterase inhibitors are ideal for fast, reliable, and very simple detection of agents in air, in water, and on surfaces.
Vladimír Pitschmann, Lukáš Matějovský, Martin Lobotka, Jan Dědič, Martin Urban, Michal Dymák   +5 more
doaj   +2 more sources

Elimination kinetics and molecular reaction mechanisms of cyclosarin (GF) by an oxime substituted β-cyclodextrin derivative in vitro

Toxicology Letters, 2015
Detoxification mechanisms of the chemical warfare agent cyclosarin (GF) in presence of 6-OxP-CD were investigated in detail in in vitro model systems. Most important finding was the preference of 6-Ox-P-CD to eliminate the more toxic (-)-GF.
Kranawetvogl, A., Müller, S., Kubik, S., Spruit, W.E.T., Thiermann, H., Worek, F., Noort, D., Reiter, G.   +7 more
openaire   +4 more sources

From Mechanisms to Materials: Oximate Reactivity and Emerging Strategies for Organophosphate Detoxification. [PDF]

Chemphyschem
The development of effective strategies for the detoxification of organophosphorus (OP) nerve agents has evolved from the early mechanistic studies of François Terrier and collaborators, who first elucidated the exceptional nucleophilicity of α‐effect species such as oximes and hydroxamates, to the modern design of supramolecular and material‐based ...
Rodríguez-Dafonte P.
europepmc   +2 more sources

Acetylcholinesterase: Structure, dynamics, and interactions with organophosphorus compounds. [PDF]

Protein Sci
Abstract Acetylcholinesterase (AChE) is an enzyme that hydrolyzes the neurotransmitter acetylcholine (ACh), removing it from the synaptic cleft after the transmission of an electrical signal, making it an essential component of chemical neurotransmission. AChE is a serine hydrolase, containing a catalytic triad of Ser/His/Glu.
Hung LW, Sanbonmatsu KY, Williams RF, Chen JC.   +3 more
europepmc   +2 more sources

Engineering Enzymes for Environmental Sustainability

Angewandte Chemie, Volume 135, Issue 52, December 21, 2023., 2023
This review highlights how engineered enzymes have been developed and implemented to help address environmental challenges. Topics include the use of engineered enzymes for improving carbon capture and utilisation, bioremediation, plastic deconstruction, and renewable feedstock generation.
Emily Radley, John Davidson, Jake Foster, Richard Obexer, Elizabeth L. Bell, Anthony P. Green   +5 more
wiley   +2 more sources

Chemical Weapons in the Iran-Iraq War (1980–1988) 3. Medical Consequences of Chemical Warfare

Вестник войск РХБ защиты, 2023
The third article in the series is dedicated to the medical consequences of the chemical warfare between Iran and Iraq during the war (1980–1988). The UN official documents and materials, declassified CIA documents, as well as other open Western and ...
M. V. Supotnitskiy, N. I. Shilo, V. A. Kovtun   +2 more
doaj   +1 more source