Results 11 to 20 of about 674 (166)

New Heterostilbene and Triazole Oximes as Potential CNS-Active and Cholinesterase-Targeted Therapeutics [PDF]

Biomolecules
New furan, thiophene, and triazole oximes were synthesized through several-step reaction paths to investigate their potential for the development of central nervous systems (CNS)-active and cholinesterase-targeted therapeutics in organophosphorus ...
Milena Mlakić, Tena Čadež, Goran Šinko, Irena Škorić, Zrinka Kovarik   +4 more
doaj   +3 more sources

Cyclosarin-An Organophosphate Nerve Agent [PDF]

Defence Science Journal, 2005
Organophosphorus compounds ascribed to as nerve agents (sarin, soman, tabun, cyclosarin) are highly toxic, and are considered to be the most dangerous chemical compounds. All apparently share a common mechanism of cholinesterase inhibition and can cause similar svmotoms. The . .
G. Krejcova, K. Kuca, L. Sevelova
openaire   +2 more sources

Reactivation Potency of New Group of Acetylcholinesterase Reactivators and Their Comparison with Currently Available Oximes

Acta Medica, 2006
In this work, in vitro potency of novel serie of monoquaternary pyridinium oximes to reactivate cyclosarin-inhibited acetylcholinesterase (AChE) was tested.
Kamil Kuča, Jan Pícha, Daniel Jun
doaj   +3 more sources

A Comparison of the Neuroprotective Efficacy of Newly Developed Oximes (K156, K203) and Currently Available Oximes (Obidoxime, HI-6) in Cyclosarin-poisoned Rats

Acta Medica, 2008
The neuroprotective effects of newly developed oximes (K156, K203) and currently available oximes (obidoxime, HI-6) in combination with atropine in rats poisoned with cyclosarin were studied.
Jiří Kassa, Jana Žďárová Karasová, Sandra Tesařová, Kamil Kuča, Kamil Musílek   +4 more
doaj   +2 more sources

The Ability of Oxime Mixtures to Increase the Reactivating and Therapeutic Efficacy of Antidotal Treatment of Cyclosarin Poisoning in Rats and Mice

Acta Medica, 2012
The reactivating and therapeutic efficacy of two combinations of oximes (HI‑6 + trimedoxime and HI‑6 + K203) was compared with the effectiveness of antidotal treatment involving single oxime (HI‑6, trimedoxime, K203) using in vivo methods.
Jiří Kassa, Jana Zdarová Karasová, Růžena Pavlíková, Filip Caisberger, Jiří Bajgar   +4 more
doaj   +2 more sources

In Vitro Reactivation of Acetylcholinesterase Inhibited by Cyclosarin Using Bisquaternary Pyridinium Aldoximes K005, K033, K027 and K048

Acta Medica, 2004
We have tested four new bisquaternary pyridinium acetylcholinesterase (AChE; EC 3.1.1.7) reactivators – K005 (1,3–bis(2–hydroxyiminomethylpyridinium) propane dibromide), K033 (1,4–bis(2–hydroxyiminomethylpyridinium) butane dibromide), K027 (1–(4 ...
Kamil Kuča, Lucie Ševelová-Bartošová, Gabriela Krejčová-Kunešová   +2 more
doaj   +2 more sources

Targeted Synthesis of 1-(4-Hydroxyiminomethylpyridinium)-3-pyridiniumpropane Dibromide – A New Nerve Agent Reactivator

Molecules, 2007
Preparation of 1-(4-hydroxy-iminomethylpyridinium)-3-pyridiniumpropane dibromide is described. This compound represents a new acetylcholinesterase (AChE) reactivator, which has no substituents on the second pyridinium ring as found in other commonly used
Jan Marek, Martina Hrabinova, Petr Stodulka, Daniel Jun, Martin Paar, Kamil Musilek, Kamil Kuca   +6 more
doaj   +2 more sources

A Comparison of the Potency of the Oxime HLö-7 and Currently Used Oximes (HI-6, Pralidoxime, Obidoxime) to Reactivate Nerve Agent-Inhibited Rat Brain Acetylcholinesterase by in vitro Methods

Acta Medica, 2005
1. The efficacy of the oxime HLö-7 and currently used oximes (pralidoxime, obidoxime, HI-6) to reactivate acetylcholinesterase inhibited by various nerve agents (sarin, tabun, cyclosarin, VX) was tested by in vitro methods. 2. Both H oximes (HLö-7, HI-6)
Kamil Kuča, Jiří Cabal, Jiří Kassa, Daniel Jun, Martina Hrabinová   +4 more
doaj   +2 more sources

Substrate Analogues for the Enzyme-Catalyzed Detoxification of the Organophosphate Nerve Agents—Sarin, Soman, and Cyclosarin

Biochemistry, 2021
The G-type nerve agents, sarin (GB), soman (GD), and cyclosarin (GF), are among the most toxic compounds known. Much progress has been made in evolving the enzyme phosphotriesterase (PTE) from Pseudomonas diminuta for the decontamination of the G-agents; however, the extreme toxicity of the G-agents makes the use of substrate analogues necessary ...
Andrew N. Bigley, Steven P. Harvey, Tamari Narindoshvili, Frank M. Raushel   +3 more
openaire   +3 more sources

Chemical Weapons in the Iran-Iraq War (1980–1988). 4. The Destruction of Iraqi Chemical Weapons

Вестник войск РХБ защиты, 2020
After the defeat of Iraqi army in Kuwait in February 1991, on April 3, the UN Security Council (UN Security Council) adopted Resolution 687, that «decides that Iraq shall unconditionally accept the destruction, removal, or rendering harmless, under ...
M. V. Supotnitskiy, N. I. Shilo, V. A. Kovtun   +2 more
doaj   +2 more sources