Efficient Detection of Nerve Agents through Carbon Nitride Quantum Dots: A DFT Approach [PDF]
Nanomaterials, 2023 V-series nerve agents are very lethal to health and cause the inactivation of acetylcholinesterase which leads to neuromuscular paralysis and, finally, death. Therefore, rapid detection and elimination of V-series nerve agents are very important. Herein,
Yasair S. S. Al-Faiyz +7 more
doaj +3 more sources
Non-quaternary oximes detoxify nerve agents and reactivate nerve agent-inhibited human butyrylcholinesterase [PDF]
Communications Biology, 2021 Amitai et al. identified 4 potential small molecule antidotes toward nerve agents poisoning by high-throughput-screening of over 150,000 compounds. Unique non-quaternary oximes represent new potential antidotes for future development as they detoxified ...
Gabriel Amitai +10 more
doaj +5 more sources
Enzymatic Decontamination of G-Type, V-Type and Novichok Nerve Agents. [PDF]
Int J Mol Sci, 2021 Organophosphorus nerve agents (OPNAs) are highly toxic compounds inhibiting cholinergic enzymes in the central and autonomic nervous systems and neuromuscular junctions, causing severe intoxications in humans.
Jacquet P +7 more
europepmc +2 more sources
Molecular Recognition of Nerve Agents and Their Organophosphorus Surrogates: Toward Supramolecular Scavengers and Catalysts. [PDF]
Chemistry, 2021 Nerve agents are tetrahedral organophosphorus compounds (OPs) that were developed in the last century to irreversibly inhibit acetylcholinesterase (AChE) and therefore impede neurological signaling in living organisms.
Finnegan TJ +2 more
europepmc +2 more sources
Fluorescence umpolung enables light-up sensing of N-acetyltransferases and nerve agents. [PDF]
Nat Commun, 2021 Intramolecular charge transfer (ICT) is a fundamental mechanism that enables the development of numerous fluorophores and probes for bioimaging and sensing.
Yan C +7 more
europepmc +2 more sources
Theoretical prediction on the hydrolysis rate of the new types of nerve agents: A density functional study [PDF]
Toxicology Reports, 2023 Although the hydrolysis mechanism of the nerve agents, which is the main decontamination pathway, has been studied experimentally and theoretically, the reliable theoretical prediction method for the hydrolysis rate is not studied yet. Furthermore, after
Md Al Mamunur Rashid +3 more
doaj +2 more sources
Poisoning by organophosphorus nerve agents and pesticides: An overview of the principle strategies and current progress of mass spectrometry-based procedures for verification. [PDF]
J Mass Spectrom Adv Clin Lab, 2021 Highlights • Evidence of poisoning with organophosphorus (OP) nerve agents requires biomedical verification.• OP nerve agents undergo common biotransformation pathways producing valuable biomarkers.• Internationally accepted methods target remaining ...
John H, Thiermann H.
europepmc +2 more sources
Organophosphorus Nerve Agents: Types, Toxicity, and Treatments. [PDF]
J Toxicol, 2020 Organophosphorus compounds are extensively used worldwide as pesticides which cause great hazards to human health. Nerve agents, a subcategory of the organophosphorus compounds, have been produced and used during wars, and they have also been used in ...
Mukherjee S, Gupta RD.
europepmc +2 more sources
Counteracting poisoning with chemical warfare nerve agents. [PDF]
Arh Hig Rada Toksikol, 2020 Phosphylation of the pivotal enzyme acetylcholinesterase (AChE) by nerve agents (NAs) leads to irreversible inhibition of the enzyme and accumulation of neurotransmitter acetylcholine, which induces cholinergic crisis, that is, overstimulation of ...
Hrvat NM, Kovarik Z.
europepmc +2 more sources
Military Medicine, 2023 Observations of military conflicts and local wars of recent decades show us that the concept of "chemical weapons" has not yet been deleted from the military lexicon of various countries, despite the convention on its prohibition.
Bova A. A. +5 more
semanticscholar +2 more sources