Results 41 to 50 of about 218,196 (253)

Interactions of cyclodextrins and their derivatives with toxic organophosphorus compounds

Beilstein Journal of Organic Chemistry, 2016
The aim of this review is to provide an update on the current use of cyclodextrins against organophosphorus compound intoxications. Organophosphorus pesticides and nerve agents play a determinant role in the inhibition of cholinesterases.
Sophie Letort, Sébastien Balieu, William Erb, Géraldine Gouhier, François Estour   +4 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Seizure and Status Epilepticus in Human Organophosphate Poisoning: A Narrative Review

Neurology International
Organophosphate (OP) exposure can trigger seizures within minutes and can rapidly evolve into status epilepticus (SE). Early seizure generation is plausibly driven by acetylcholinesterase inhibition, leading to central cholinergic overstimulation.
Giuseppe Magro, Oreste Marsico, Federico Tosto, Concetta Lobianco, Laura Rapisarda, Giovanni Mastroianni, Angelo Pascarella   +6 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Exploiting macrocyclic polylactam for sensing V-series nerve agents: A computational study

Results in Chemistry
The nerve agents are organophosphorus compounds (OPs) developed as chemical warfare agents (CWAs) that inhibit acetylcholinesterase (AChE) and lead to impeding neurological signals in mammals.
Dipankar Das, Bishwajit Ganguly
doaj   +1 more source

Chemical Weapons: History of the Study of Organophosphorus Toxic Agents Abroad

Вестник войск РХБ защиты, 2023
Organophosphorus compounds occupy a unique positon among all chemical warfare agents (CWA's). Since the 1930-s their high toxicity, wide range of physical-chemical properties and complex action attracted close attention of foreign military experts.
I. A. Nelga, I. V. Medvetsky, A. V. Zlobin, S. V. Tretyakov, A. V. Sherstyuk, I. V. Kostyuchenko   +5 more
doaj   +1 more source

The pyruvate generator is a common phenomenon in mitochondria from different rat and mouse brain regions

FEBS Letters, EarlyView.
The pyruvate generator, which causes activation of respiration by extra‐mitochondrial Ca2+, is also present and functional in rat brainstem mitochondria, as it is in other brain regions. This finding is confirmed by experiments with a fully reconstituted malate–aspartate shuttle (MAS).
Grazyna Debska‐Vielhaber, Niki Karavasili, Matthias Kunz, Zemfira Gizatullina, Timur Gainutdinov, Stefan Vielhaber, Wolfram S. Kunz, Frank N. Gellerich   +7 more
wiley   +1 more source

Investigating possibilities and recent trends for the development of novel decontamination technologies [PDF]

Scientific Technical Review
Despite international prohibition of chemical warfare agents (CWAs), defined in Chemical Weapons Convention, recent events during military conflict in Syria and isolated events in Salisbury (UK) and Kuala Lumpur (Malesya) airport prove that these agents ...
Vitorović-Todorović Maja D., Vujatović-Velimirov Tamara B.   +1 more
doaj   +1 more source

Development of acetylcholinesterase immobilized CMD (Carboxymethyldextran) chip-based sensor for the detection of nerve agent simulant parathion

Cumhuriyet Science Journal, 2020
In this study, a carboxymethyldextran chip based sensor system is developed that selectively recognizes and binds nerve agent molecules used in chemical weapons. Nerve agents fall under the group of organophosphorus compounds and irreversibly inhibit the
Ozan Yağmuroğlu, Sibel Emir Diltemiz
doaj   +1 more source

Nerve Agents and Their Detection [PDF]

Journal of Sensor Science and Technology, 2014
Nerve agents are major chemical warfare agents with the “G series” and “V series” being the most widely known because of their lethal effect. Although not conspicuously used in major wars, the potential detrimental impact on modern society had been revealed from the sarin terror attack on Tokyo subway, which affected thousands of people.
Young Jun Kim, Jae Doo Huh
openaire   +1 more source