Results 41 to 50 of about 1,816,017 (199)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Nerve-terminal And Schwann-cell Response After Nerve Injury In The Absence Of Nitric Oxide.

, 2015
Dystrophic muscles show alterations in the dystrophin-glycoprotein complex and a lack of neuronal nitric oxide (NO) synthase. In mdx mice, presynaptic expression of neuronal NO synthase is decreased, suggesting that presynaptic signaling may be altered ...
Marques, Maria Julia, Minatel, Elaine, Pereira, Elaine Cristina Leite, Neto, Humberto Santo   +3 more
core   +2 more sources

Chemical Weapons: History of the Study of Organophosphorus Toxic Agents Abroad

Вестник войск РХБ защиты, 2023
Organophosphorus compounds occupy a unique positon among all chemical warfare agents (CWA's). Since the 1930-s their high toxicity, wide range of physical-chemical properties and complex action attracted close attention of foreign military experts.
I. A. Nelga, I. V. Medvetsky, A. V. Zlobin, S. V. Tretyakov, A. V. Sherstyuk, I. V. Kostyuchenko   +5 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Fluorometric and Colorimetric Biosensors for the Assay of Cholinesterase Inhibitors

Sensors
Cholinesterases, specifically acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), play critical roles in neurotransmission and are key targets for inhibitors with therapeutic and toxicological significance.
Miroslav Pohanka
doaj   +1 more source

Investigating possibilities and recent trends for the development of novel decontamination technologies [PDF]

Scientific Technical Review
Despite international prohibition of chemical warfare agents (CWAs), defined in Chemical Weapons Convention, recent events during military conflict in Syria and isolated events in Salisbury (UK) and Kuala Lumpur (Malesya) airport prove that these agents ...
Vitorović-Todorović Maja D., Vujatović-Velimirov Tamara B.   +1 more
doaj   +1 more source

Development of acetylcholinesterase immobilized CMD (Carboxymethyldextran) chip-based sensor for the detection of nerve agent simulant parathion

Cumhuriyet Science Journal, 2020
In this study, a carboxymethyldextran chip based sensor system is developed that selectively recognizes and binds nerve agent molecules used in chemical weapons. Nerve agents fall under the group of organophosphorus compounds and irreversibly inhibit the
Ozan Yağmuroğlu, Sibel Emir Diltemiz
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Paraoxonase (PON1) and Detoxication of Nerve Agents

, 2015
Paraoxonase (PON1) is a serum and liver enzyme that can hydrolyze in vitro a number of organophosphorus (OP) compounds, including the active metabolites of specific OP insecticides, and certain OP nerve agents such as sarin and soman.
Furlong C. E., Costa L. G., Cole T. B.
core   +1 more source

From energy-rich phosphate compounds to warfare agents: A review on the chemistry of organic phosphate compounds

Orbital: The Electronic Journal of Chemistry, 2008
The chemistry of the phosphorus-oxygen bond is widely used in biological systems in many processes, such as energy transduction and the storage, transmission and expression of genetic information, which are essential to living beings in relation to a ...
Luciano Albino Giusti, Vanderlei Gageiro Machado   +1 more
doaj   +1 more source