Results 51 to 60 of about 2,868 (201)
Chronic behavioral and cognitive deficits in a rat survival model of paraoxon toxicity [PDF]
, 2014 Organophosphate (OP) compounds, including paraoxon (POX), are similar to nerve agents such as sarin. There is a growing concern that OP agents could be weaponized to cause mass civilian causalities.
DeLorenzo, Robert J. +3 more
core +2 more sources
The Influence of Oxime Selection on the Efficacy of Antidotal Treatment of Soman-Poisoned Rats
Acta Medica, 2002 1. The influence of some acetylcholinesterase reactivators (HI-6, obidoxime, pralidoxime) on the efficacy of antidotal treatment to eliminate soman-induced disturbance of respiration and circulation and to protect experimental animals poisoned with ...
Jiří Kassa, Josef Fusek
doaj +1 more source
The Subcutaneous Injection of Organophosphate: A Case Report
International Journal of Medical Toxicology and Forensic Medicine, 2021 Organophosphate (OP) poisoning is prevalent in developing countries. Toxicity occurs by voluntary injection, inhalation, and absorption. Self-injection is rare.
Shafeajafar Zoofaghari +4 more
doaj +1 more source
SeparationsPralidoxime chloride, a highly hydrophilic antidote, cannot be effectively separated by reverse-phase high-performance liquid chromatography (RP-HPLC), unless the mobile-phase composition is varied.
Bohyun Shin +10 more
doaj +1 more source
Acta Medica, 2004 The oxime K005 [1,3–bis(2–hydroxyiminomethylpyridinium) propane dibromide] for the reactivation of the enzyme acetylcholinesterase (AChE) inhibited by cyclosarin and VX was tested.
Kamil Kuča, Vlastimil Dohnal
doaj +1 more source
Pediatric Preparedness for Disasters and Terrorism: A National Consensus Conference: Executive Summary [PDF]
, 2003 In a time of crisis, it is essential to ensure the needs of children are being met in planning and preparing for disasters and terrorist events. The current adult models and guidelines cannot be applied to the care of children.
Markenson, David, Redlener, Irwin E.
core +2 more sources
Epilepsia Open, Volume 10, Issue 4, Page 1187-1198, August 2025.Abstract Objective A benzodiazepine (diazepam or midazolam) is one of the current standards of care therapies to effectively terminate organophosphorus nerve agent‐induced status epilepticus when administered shortly after onset. Preclinical studies showed that benzodiazepines were less effective in stopping status epilepticus when treatment was ...
Hailey G. Steier +8 more
wiley +1 more source
Acta Medica, 2006 In this work, in vitro potency of novel serie of monoquaternary pyridinium oximes to reactivate cyclosarin-inhibited acetylcholinesterase (AChE) was tested.
Kamil Kuča, Jan Pícha, Daniel Jun
doaj +1 more source
Epilepsia, Volume 66, Issue 4, Page 1329-1342, April 2025.Abstract Objective Acute organophosphate (OP) intoxication affects a significant number of individuals worldwide. Those who survive OP‐induced cholinergic crisis, which includes status epilepticus, often develop neurological morbidities. Here, we provide a rigorous characterization of the acute and delayed electrophysiological responses to OP ...
Jeremy A. MacMahon +8 more
wiley +1 more source
Clay-biosurfactant materials as functional drug delivery systems: Slowing down effect in the in vitro release of cinnamic acid [PDF]
, 2017 The main objectives of the present paper were the preparation and characterization of new surfactant-modified clays and the evaluation of their potential applicability as drug delivery systems for the oral administration of the cinnamic acid (CA) drug ...
Calabrese, I +4 more
core +1 more source