Results 51 to 60 of about 2,059 (195)

Outcome of treatment of OPC poisoning patients with atropine or atropine plus pralidoxime

, 2018
Background: Organophosphorus compound (OPC) poisoning is common in Bangladesh and management facility is not adequate in most hospitals. Both inj. Atropine and inj.
AKM Mamunur Rashid, SM Kamal, Poritosh Kumar Chowdhury, Shamima Akhter, Md Nazrul Islam, Sk Farid Uddin Ahmed   +5 more
core   +1 more source

The role of plasmapheresis in organophosphate poisoning: Case reports of three pediatric patients

The Turkish Journal of Pediatrics, 2017
The aim of the study was to assess the impact of plasmapheresis treatment in the management of three pediatric patients with organophosphate poisoning who did not respond to standard treatment.
Ufuk Yükselmiş, Mustafa Özçetin, Yakup Çağ, Dinçer Yıldızdaş, Hayri Levent Yılmaz   +4 more
doaj   +1 more source

Comparison of Single-Dose Pralidoxime and Pralidoxime Infusions for the Treatment of Organophosphate Poisoning

Turkiye Klinikleri Journal of Medical Sciences, 2012
Objective: Organic phosphates (OP) bind covalently to acetylcholinesterase (AChE) and acetylcholine (Ach) accumulates in the synaptic cleft. Administering oximes before aging process causes breakage of the covalent bond between OP-AChE, and allows reactivation of AChE. Pralidoxime (PAM) is the most commonly used oxime.
Kozaci, Nalan, Gokel, Yuksel, Acikalin, Ayca, Icme, Ferhat   +3 more
openaire   +1 more source

Acute and persistent changes in neural oscillatory activity predict development of epilepsy following acute organophosphate intoxication in adult rats

Epilepsia, Volume 66, Issue 4, Page 1329-1342, April 2025.
Abstract Objective Acute organophosphate (OP) intoxication affects a significant number of individuals worldwide. Those who survive OP‐induced cholinergic crisis, which includes status epilepticus, often develop neurological morbidities. Here, we provide a rigorous characterization of the acute and delayed electrophysiological responses to OP ...
Jeremy A. MacMahon, Peter M. Andrew, Ali Izadi, Donald A. Bruun, Naomi H. Saito, Daniel J. Tancredi, Amy Brooks‐Kayal, Pamela J. Lein, Gene G. Gurkoff   +8 more
wiley   +1 more source

A Comparison of the Potency of the Oxime HLö-7 and Currently Used Oximes (HI-6, Pralidoxime, Obidoxime) to Reactivate Nerve Agent-Inhibited Rat Brain Acetylcholinesterase by in vitro Methods

Acta Medica, 2005
1. The efficacy of the oxime HLö-7 and currently used oximes (pralidoxime, obidoxime, HI-6) to reactivate acetylcholinesterase inhibited by various nerve agents (sarin, tabun, cyclosarin, VX) was tested by in vitro methods. 2. Both H oximes (HLö-7, HI-6)
Kamil Kuča, Jiří Cabal, Jiří Kassa, Daniel Jun, Martina Hrabinová   +4 more
doaj   +1 more source

Cu‐Based Nanomaterials for Oxime Electrosynthesis: Advances, Challenges, and Perspectives

cMat, Volume 2, Issue 1, March 2025.
ABSTRACT Cu‐based nanomaterials have demonstrated great potential for catalyzing the electrosynthesis of oxime compounds, a type of organonitrogen molecule that finds versatile applications in the pharmaceutical industry, medicine production, chemical feedstocks, and other fields.
Xun‐Ying Liu, Zi‐Yi Liu, Hao‐Zheng Chen, Rui‐Kai Li, Le Li, Zheng‐Hua Tang   +5 more
wiley   +1 more source

Allopregnanolone as an Adjunct Therapy to Midazolam is More Effective Than Midazolam Alone in Suppressing Soman‐Induced Status Epilepticus in Male Rats

CNS Neuroscience &Therapeutics, Volume 31, Issue 3, March 2025.
Acute poisoning with the organophosphate, soman, triggers status epilepticus that rapidly becomes refractory to standard of care treatment with midazolam (MDZ). Combined treatment with MDZ and allopregnanolone (ALLO) significantly suppresses seizure activity, which is associated with attenuated neurodegeneration and neuroinflammation.
Peter M. Andrew, Jeremy A. MacMahon, Xiuzhen Liu, Naomi H. Saito, Kyle E. Berger, Julia E. Morgan, Ashish Dhir, Danielle J. Harvey, Hilary S. McCarren, Michael A. Rogawski, Pamela J. Lein   +10 more
wiley   +1 more source

Efficacy Assessment of an Uncharged Reactivator of NOP-Inhibited Acetylcholinesterase Based on Tetrahydroacridine Pyridine-Aldoxime Hybrid in Mouse Compared to Pralidoxime

Biomolecules, 2020
(1) Background: Human exposure to organophosphorus compounds employed as pesticides or as chemical warfare agents induces deleterious effects due to cholinesterase inhibition. One therapeutic approach is the reactivation of inhibited acetylcholinesterase
André-Guilhem Calas, Anne-Sophie Hanak, Nina Jaffré, Aurélie Nervo, José Dias, Catherine Rousseau, Charlotte Courageux, Xavier Brazzolotto, Pascal Villa, Adeline Obrecht, Jean-François Goossens, Christophe Landry, Johan Hachani, Fabien Gosselet, Marie-Pierre Dehouck, Jagadeesh Yerri, Maria Kliachyna, Rachid Baati, Florian Nachon   +18 more
doaj   +1 more source

Nicotine Replacement Combined with a Novel Compound (ProBAN) for Smoking Cessation: A Pilot Study

Canadian Respiratory Journal, 2001
BACKGROUND: Smoking cessation rates with available pharmacological therapies remain suboptimal. Anecdotal observations with a combination of sublingual pralidoxime and ipratropium (ProBAN) suggested that these agents in combination with nicotine gum ...
Richard Leigh, Norman M Viner, Gerard Cox, Jeffrey W Balon, Douglas MC Wilson, Denise O’Shaughnessy, Corinne Walker, Gerry Brosky, Malcolm R Sears   +8 more
doaj   +1 more source

Accidental organophosphate poisoning: A case series of 2 pediatric coumaphos exposures

Journal of the American College of Emergency Physicians Open, 2022
Introduction Pediatric organophosphate insecticide poisonings are rare in the United States, and life‐threatening toxicity is rarely seen. We report 2 accidental ingestions of the organophosphate insecticide coumaphos that resulted in life‐threatening ...
Justin A. Seltzer, Sarah Friedland, Nathan A. Friedman, Garret A. Winkler, Emily Foreman, Yousef Al Mubarak, Brent Buccine, Branden Engorn, Allyson Kreshak, Alicia Minns, Christian A. Tomaszewski, Daniel R. Lasoff, Richard F. Clark   +12 more
doaj   +1 more source