Results 1 to 10 of about 1,662,226 (149)

Pralidoxime in acute organophosphorus insecticide poisoning--a randomised controlled trial. [PDF]

PLoS Medicine, 2009
BackgroundPoisoning with organophosphorus (OP) insecticides is a major global public health problem, causing an estimated 200,000 deaths each year.
Michael Eddleston, Peter Eyer, Franz Worek, Edmund Juszczak, Nicola Alder, Fahim Mohamed, Lalith Senarathna, Ariyasena Hittarage, Shifa Azher, K Jeganathan, Shaluka Jayamanne, Ludwig von Meyer, Andrew H Dawson, Mohamed Hussain Rezvi Sheriff, Nick A Buckley   +14 more
doaj   +3 more sources

Efficacy Assessment of an Uncharged Reactivator of NOP-Inhibited Acetylcholinesterase Based on Tetrahydroacridine Pyridine-Aldoxime Hybrid in Mouse Compared to Pralidoxime

Biomolecules, 2020
(1) Background: Human exposure to organophosphorus compounds employed as pesticides or as chemical warfare agents induces deleterious effects due to cholinesterase inhibition. One therapeutic approach is the reactivation of inhibited acetylcholinesterase
André-Guilhem Calas, Anne-Sophie Hanak, Nina Jaffré, Aurélie Nervo, José Dias, Catherine Rousseau, Charlotte Courageux, Xavier Brazzolotto, Pascal Villa, Adeline Obrecht, Jean-François Goossens, Christophe Landry, Johan Hachani, Fabien Gosselet, Marie-Pierre Dehouck, Jagadeesh Yerri, Maria Kliachyna, Rachid Baati, Florian Nachon   +18 more
doaj   +2 more sources

A network-based computational and experimental framework for repurposing compounds toward the treatment of non-alcoholic fatty liver disease

iScience, 2022
Summary: Non-alcoholic fatty liver disease (NAFLD) is among the most common liver pathologies, however, none approved condition-specific therapy yet exists.
Danae Stella Zareifi, Odysseas Chaliotis, Nafsika Chala, Nikos Meimetis, Maria Sofotasiou, Konstantinos Zeakis, Eirini Pantiora, Antonis Vezakis, George K. Matsopoulos, Georgios Fragulidis, Leonidas G. Alexopoulos   +10 more
doaj   +2 more sources

Why Do the Results of Studies on the Effectiveness of Pralidoxime for Treatment of Organophosphate Poisoning Vary? [PDF]

Asia Pacific Journal of Medical Toxicology, 2015
Organophosphate (OP) compounds are frequently used agorchemicals for deliberate self-harm in some parts of the world resulting in high mortality and morbidity.
Ashish Bhalla, Surjit Singh
doaj   +2 more sources

Neuroprotective Effects of N-Acetylcysteine-Amide (AD4) in a Survival Mouse Model of Paraoxon Intoxication: Targeting Oxidative Stress, Neuroinflammation and Memory Impairments [PDF]

Antioxidants
Neurotoxicity induced by organophosphorus (OP) compounds such as paraoxon (POX) leads to severe brain damage and cognitive impairments. Although current treatments alleviate acute cholinergic symptoms, they fail to address secondary neurotoxicity.
Edurne Urquizu, Marine Cuiller, Georgia Papadopoulou, David Pubill, Demetrio Raldúa, Jordi Camarasa, Elena Escubedo, Raul López-Arnau   +7 more
doaj   +2 more sources

Case Report: Organophosphorus Section Poisoning-Induced Intermediate Extrapyramidal Syndrome [PDF]

Journal of Clinical and Diagnostic Research, 2023
Organophosphate (OP) compounds are one of the most common agents used for deliberate self-harm in developing countries, including India. OP compounds inhibit the enzyme acetylcholinesterase, which is responsible for hydrolysing the neurotransmitter ...
Puneeth M Reddy, Karthik CH Reddy
doaj   +1 more source

Design, synthesis, in silico studies and in vitro evaluation of isatin-pyridine oximes hybrids as novel acetylcholinesterase reactivators

Journal of Enzyme Inhibition and Medicinal Chemistry, 2021
Organophosphorus poisoning caused by some pesticides and nerve agents is a life-threating condition that must be swiftly addressed to avoid casualties. Despite the availability of medical countermeasures, the clinically available compounds lack a broad ...
Daniel A. S. Kitagawa, Rafael B. Rodrigues, Thiago N. Silva, Wellington V. dos Santos, Vinicius C. V. da Rocha, Joyce S. F. D. de Almeida, Leandro B. Bernardo, Taynara Carvalho-Silva, Cintia N. Ferreira, Angelo A. T. da Silva, Alessandro B. C. Simas, Eugenie Nepovimova, Kamil Kuča, Tanos C. C. França, Samir F. de A. Cavalcante   +14 more
doaj   +1 more source

Organophosphorus Poisoning with Homicidal Intention in a Neonate

Indian Journal of Neonatal Medicine and Research, 2022
Organophosphorus Compounds (OPC) are widely used as pesticides, and poisoning due to OPC is very rare in neonates. A 12-day- old female neonate was admitted with gasping respiration, excessive oral secretions and cold extremities.
Laxman Basany, Roja Aepalapala
doaj   +1 more source

Therapy of Organophosphate Poisoning via Intranasal Administration of 2-PAM-Loaded Chitosomes

Pharmaceutics, 2022
Chitosan-decorated liposomes were proposed for the first time for the intranasal delivery of acetylcholinesterase (AChE) reactivator pralidoxime chloride (2-PAM) to the brain as a therapy for organophosphorus compounds (OPs) poisoning.
Elmira A. Vasilieva, Darya A. Kuznetsova, Farida G. Valeeva, Denis M. Kuznetsov, Andrey V. Zakharov, Syumbelya K. Amerhanova, Alexandra D. Voloshina, Irina V. Zueva, Konstantin A. Petrov, Lucia Ya. Zakharova   +9 more
doaj   +1 more source

Therapeutic effects of HESA-A (a herbal-marine compound) in acute organophosphorus pesticide poisoning [PDF]

Avicenna Journal of Phytomedicine, 2020
Objective: Organophosphorus compounds (OPs) are common causes of poisonings. Atropine and oximes are pharmacological antidotes of OPs. However, because of their adverse effects and insufficient performance, several other compounds have been evaluated as ...
Seyed Reza Mousavi, Mohammad Moshiri, Emadodin Darchini-Maragheh, Seyed Khosro Ghasempouri, Bita Dadpour, Faezeh Sardar Antighechi, Mahdi Balali-Mood   +6 more
doaj   +1 more source