Novel Group of AChE Reactivators—Synthesis, In Vitro Reactivation and Molecular Docking Study
Molecules, 2018 The acetylcholinesterase (AChE) reactivators (e.g., obidoxime, asoxime) became an essential part of organophosphorus (OP) poisoning treatment, together with atropine and diazepam.
David Malinak +4 more
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Disentangling the formation, mechanism, and evolvement of the covalent methanesulfonyl fluoride acetylcholinesterase adduct: Insights into an aged-like inactive complex susceptible to reactivation by a combination of nucleophiles. [PDF]
Protein SciAbstract Chemical warfare nerve agents and pesticides, known as organophosphorus compounds inactivate cholinesterases (ChEs) by phosphorylating the serine hydroxyl group located at the active site of ChEs. Over the course of time, phosphorylation is followed by loss of an organophosphate‐leaving group and the bond with ChEs becomes irreversible, a ...
Stojan J, Pesaresi A, Meden A, Lamba D.
europepmc +2 more sources
Acute Organophosphate Poisoning Induced Extrapyramidal Syndrome: A Case Report [PDF]
Asia Pacific Journal of Medical Toxicology, 2019 Background: Organophosphorus compound ingestion is one of the most common modes of deliberate self-harm in developing countries like India. Neurological complications are known in acute, intermediate and delayed phases following organophosphate poisoning.
B Saroj Prusty +4 more
doaj +1 more source
Kvalitativna procjena eliminacije TCP-a i TAMORF-a iz organizma štakora metodom GC-MS [PDF]
, 2010 Nerve agents are highly toxic organophosphorus (OP) compounds. They inhibit acetylcholinesterase (AChE), an enzyme that hydrolyses acetycholine (ACh) in the nervous system.
A. Lucić Vrdoljak +20 more
core +2 more sources
Pharmacological applications of azomethine derivatives in the therapy of different diseases [PDF]
PharmaciaCompounds with an azomethine structure belong to different chemical classes—they are hydrazones, phenylhydrazones, semicarbazones, thiosemicarbazones, and oximes.
Ivanka Pencheva +2 more
doaj +3 more sources
Clay-biosurfactant materials as functional drug delivery systems: Slowing down effect in the in vitro release of cinnamic acid [PDF]
, 2017 The main objectives of the present paper were the preparation and characterization of new surfactant-modified clays and the evaluation of their potential applicability as drug delivery systems for the oral administration of the cinnamic acid (CA) drug ...
Calabrese, I +4 more
core +1 more source
Chronic behavioral and cognitive deficits in a rat survival model of paraoxon toxicity [PDF]
, 2014 Organophosphate (OP) compounds, including paraoxon (POX), are similar to nerve agents such as sarin. There is a growing concern that OP agents could be weaponized to cause mass civilian causalities.
DeLorenzo, Robert J. +3 more
core +2 more sources
A study on serum cholinesterase level in deaths due to organophosphorus compounds poisoning
, 2020 Organophosphorus compounds are widely used in agriculture and horticulture. Poisoning by these organo phosphorus compounds are accidental exposure or with suicidal intention. Self consumption of organophosphorus compounds is a common worldwide health
S. Devi, T.Vedanayagam
semanticscholar +1 more source
Efficacy of pralidoxime in organophosphorus poisoning: revisiting the controversy in Indian setting.
Journal of Postgraduate Medicine, 2014 CONTEXT Poisoning with organophosphorus (OP) compounds constitutes a global public health problem. Standard treatment of OP poisoning involves use of atropine and pralidoxime.
I. Banerjee, S. Tripathi, A. S. Roy
semanticscholar +1 more source
Miotoxicidade por organofosforados Organophosphate myotoxicity
Revista de Saúde Pública, 1996 Os organofosforados são um grupo de compostos químicos amplamente utilizados em agropecuária como inseticidas, ocasionando intoxicações acidentais em animais e humanos, e mesmo sendo utilizados em tentativas de suicídio.
Maria J. Cavaliere +3 more
doaj +1 more source