Pralidoxime in acute organophosphorus insecticide poisoning--a randomised controlled trial.
PLoS Medicine, 2009 BackgroundPoisoning with organophosphorus (OP) insecticides is a major global public health problem, causing an estimated 200,000 deaths each year.
Michael Eddleston +14 more
doaj +1 more source
Therapeutic effects of HESA-A (a herbal-marine compound) in acute organophosphorus pesticide poisoning [PDF]
Avicenna Journal of Phytomedicine, 2020 Objective: Organophosphorus compounds (OPs) are common causes of poisonings. Atropine and oximes are pharmacological antidotes of OPs. However, because of their adverse effects and insufficient performance, several other compounds have been evaluated as ...
Seyed Reza Mousavi +6 more
doaj +1 more source
BIBLIOMETRIC ANALYSIS OF THEMES AND TRENDS IN ORGANOPHOSPHORUS POISONING RESEARCH WITH TEXT MINING.
Student's Journal of Health Research Africa, 2023 Background: Organophosphorus poisoning is a global health concern.This study uses an integrated strategy to assess the research landscape, combining quantitative analysis of publishing trends with automated extraction of information from text data ...
Avinash J. Pujari, Bidhan Dolai
doaj +1 more source
Atropine Use in Children After Nerve Gas Exposure [PDF]
, 2004 Following the FDA's approval of a pediatric dosage Atropen®, the Pediatric Expert Advisory Panel was asked to review the existing guidelines and recommendations regarding the treatment of children exposed to nerve agents and the Mark-1 Kit; review the ...
National Center for Disaster Preparedness
core +2 more sources
Organophosphorus compounds and oximes: a critical review
Archives of Toxicology, 2020 Organophosphorus (OP) pesticides and nerve agents still pose a threat to the population. Treatment of OP poisoning is an ongoing challenge and burden for medical services.
F. Worek, H. Thiermann, T. Wille
semanticscholar +1 more source
Drug Testing and Analysis, 2020 Oximes such as pralidoxime (2-PAM), obidoxime (Obi), and HI-6 are the only currently available therapeutic agents to reactivate inhibited acetylcholinesterase (AChE) in case of intoxications with organophosphorus (OP) compounds.
T. Kranawetvogl +3 more
semanticscholar +1 more source
Pharmacological Blockade of the Calcium Plateau Provides Neuroprotection Following Organophosphate Paraoxon Induced Status Epilepticus in Rats [PDF]
, 2016 Organophosphate (OP) compounds which include nerve agents and pesticides are considered chemical threat agents. Currently approved antidotes are crucial in limiting OP mediated acute mortality.
Ajdacic-Gross +43 more
core +2 more sources
In Vitro Cysteine Reactivates Organophosphate Insecticide Dichlorvos-Inhibited Human Cholinesterases
Sultan Qaboos University Medical Journal, 2017 Objectives: Organophosphate (OP) pesticides inhibit both red blood cell (RBC) and plasma cholinesterases (ChEs). Oximes, especially pralidoxime (2-PAM), are widely used as antidotes to treat OP poisoning.
Hamidreza Mohammadi +3 more
doaj +1 more source
A phase II clinical trial to assess the safety of clonidine in acute organophosphorus pesticide poisoning [PDF]
, 2009 Background An estimated 2–3 million people are acutely poisoned by organophosphorus pesticides each year, mostly in the developing world. There is a pressing need for new affordable antidotes and clonidine has been shown to be effective in animal studies.
Karunatilake Harindra +6 more
core +1 more source
Transitioning from Oxime to the Next Potential Organophosphorus Poisoning Therapy Using Enzymes
Journal of Chemistry, 2021 For years, organophosphorus poisoning has been a major concern of health problems throughout the world. An estimated 200,000 acute pesticide poisoning deaths occur each year, many in developing countries.
Rauda A. Mohamed +7 more
doaj +1 more source