The Experimental Oxime K027—A Promising Protector From Organophosphate Pesticide Poisoning. A Review Comparing K027, K048, Pralidoxime, and Obidoxime [PDF]
Frontiers in Neuroscience, 2019 Poisoning with organophosphorus compounds (OPCs) is a major problem worldwide. Standard therapy with atropine and established oxime-type enzyme reactivators (pralidoxime, obidoxime) is unsatisfactory.
Dietrich E. Lorke +2 more
doaj +4 more sources
A Study on Two Dose Regimens of Pralidoxime in the Management of Organophosphate Poisoning [PDF]
Asia Pacific Journal of Medical Toxicology, 2013 Background: The role and proper dose of pralidoxime in the treatment of Organophosphorus (OP) compounds poisoning is an unresolved issue .This study was designed to compare the regimen recommended by the World Health Organization (WHO) with the commonly ...
Mahadevaiah Mahesh +2 more
doaj +1 more source
Computational Design, Molecular Docking Study and Toxicity Prediction of Some Novel Pralidoxime Derivatives as reactivators of acetyl cholinesterase enzyme [PDF]
Journal of Advanced Biomedical Sciences, 2019 Background & Objective: oximes as Acetylcholinesterase (AChE) reactivators were developed for the treatment of organophosphate compounds (OPCs) intoxication.
abozar roeintan
doaj +1 more source
Pharmacokinetic Studies on Oximes in Organophosphate Poisoning: A Mini Review [PDF]
Asia Pacific Journal of Medical Toxicology, 2014 Organophosphate (OP) poisoning is one of the most common causes of poisoning in developing countries especially in Southeastern Asia. Poisoning with phosphorus-containing organic chemicals or OP compounds can be managed with antidotes like oximes which ...
Girish Thunga +6 more
doaj +1 more source
Comparative Study of Continuous Pralidoxime Infusion versus Intermittent Dosing: Application of High-Performance Liquid Chromatography Method on Serum of Organophosphate Poisoned Patients [PDF]
Asia Pacific Journal of Medical Toxicology, 2013 Background: The effective therapeutic dose of pralidoxime methylsulphate for organophosphate (OP) poisoning is necessary to be clarified. This study was designed to comparatively assess the blood level of pralidoxime (BPL) and clinical outcomes in OP ...
Girish Thunga +7 more
doaj +1 more source
A Whiff of Garlic, a Turn of Fate: Recognizing Organophosphorus Poisoning Amid Diagnostic Uncertainty: A Case Report. [PDF]
Clin Case RepABSTRACT OP compounds, commonly used as pesticides, are readily available over the counter and frequently implicated in intentional poisoning. We report a case of a 43‐year‐old male with OP poisoning initially misdiagnosed as alcohol intoxication. He was intubated in the emergency department on arrival due to a low Glasgow Coma Scale (GCS) of 6/15 and ...
Tamang S +6 more
europepmc +2 more sources
Organophosphate Poisoning: Insights From a Case Report of Acute Cholinergic Syndrome. [PDF]
Clin Case RepABSTRACT Organophosphate (OP) pesticides are widely used in agriculture and can cause acute cholinergic toxicity by inhibiting the enzyme acetylcholinesterase, leading to an accumulation of acetylcholine. A 45‐year‐old male plumber was admitted to the emergency department 4 h after ingesting an unknown quantity of a 50% emulsifiable concentration of ...
Bereda G.
europepmc +2 more sources
Atrial Fibrillation Following Acute Malathion Ingestion: A Rare Cardiac Manifestation of Organophosphate Poisoning. [PDF]
Clin Case RepABSTRACT Organophosphate poisoning can precipitate acute atrial fibrillation even in previously healthy individuals. This first documented case from Pakistan of Malathion‐induced atrial fibrillation emphasizes the need for early recognition, continuous cardiac monitoring, prompt atropine and pralidoxime therapy, electrolyte correction, and timely ...
Ain QU, Hamza M, Rehman A, Omarzai RG.
europepmc +2 more sources
From Mechanisms to Materials: Oximate Reactivity and Emerging Strategies for Organophosphate Detoxification. [PDF]
ChemphyschemThe development of effective strategies for the detoxification of organophosphorus (OP) nerve agents has evolved from the early mechanistic studies of François Terrier and collaborators, who first elucidated the exceptional nucleophilicity of α‐effect species such as oximes and hydroxamates, to the modern design of supramolecular and material‐based ...
Rodríguez-Dafonte P.
europepmc +2 more sources
Return to Spontaneous Circulation in a Patient With Cholinergic Syndrome at the Emergency Department of Buea Regional Hospital, Cameroon. [PDF]
Clin Case RepABSTRACT With the increasing misuse of herbal treatment and pesticides, cases of cholinergic syndrome following herbal treatment or organophosphate poisoning have become increasingly common in our milieu. However, when advanced, mortality is high. We report the successful management of a case involving a 54‐year‐old African female with a known history ...
Nteungue BBK +3 more
europepmc +2 more sources