Results 61 to 70 of about 1,662,226 (149)

A case of fenitrothion self-poisoning with prolonged clinical features

Toxicology Communications
Background Organophosphorus compounds cause toxicity, typically within a few hours following oral exposure, by inhibiting acetylcholinesterase. We report a case of fenitrothion ingestion with delayed onset of severe muscarinic symptoms.Case report A 56 ...
Kaiho Hirata, Takuyo Chiba, Steven Bird, Naoki Shida, Koji Yamaguchi, Daisuke Yajima, Koji Masuda, Takashi Shiga   +7 more
doaj   +1 more source

Recent Advances in the Treatment of Organophosphorous Poisonings [PDF]

Iranian Journal of Medical Sciences, 2012
Organophosphorous compounds have been employed as pesticides and chemical warfare nerve agents. Toxicity of organophosphorous compounds is a result of excessive cholinergic stimulation through inhibition of acetyl cholinesterase.
Mahdi Balali-Mood, Hamidreza Saber
doaj  

Supramolecular Approaches to the Detoxification of Nerve Agents

Israel Journal of Chemistry, Volume 64, Issue 6-7, July 2024.
Abstract A promising, but not yet practiced, approach to the treatment of neurotoxic organophosphate poisoning is the administration of a scavenger that rapidly deactivates the nerve agent before it can exert its toxic effects. The detoxification rates required for successful use of this therapy can currently only be achieved with enzymes, but ...
Stefan Kubik
wiley   +1 more source

Use of palladium(II) chloride as colour-forming reagent in determination of pralidoxime chloride in water and tablets

, 1988
Pralidoxime chloride (PAM-2Cl) has been determined spectrophotometrically in Britton-Robinson buffer solution at pH = 6.45; the method is based on measurement of the absorbance of the Pd(II)-pralidoxime complex at 327 nm.
Binenfeld, Z.J., K. Karljiković-Rajic, Z. Binenfeld, Karljiković-Rajić, Katarina, Granov, A, B. Stanković, A. Granov, Stanković, B   +7 more
core   +1 more source

Reversal of Cardiovascular Toxicity in Severe Organophosphate Poisoning with 20% Intralipid Emulsion Therapy: Case Report and Review of Literature [PDF]

Asia Pacific Journal of Medical Toxicology, 2014
Background: Cardiac toxicity is one of the life-threatening effects of severe organophosphate (OP) poisoning. We presented a patient with severe OP poisoning, in cardiovascular shock poorly responsive to conventional treatments, who could be resuscitated
Shafat Ahmad Mir, Rafia Rasool
doaj  

Preparation and evaluation of pralidoxime-loaded plga nanoparticles as potential carriers of the drug across the blood brain barrier

, 2015
Pralidoxime is an organophosphate antidote with poor central nervous system distribution due to a high polarity. In the present study, pralidoxime-loaded poly(lactic-co-glycolic acid) nanoparticles were prepared and evaluated as a potential delivery ...
Maposa, Prosper, Dube, Admire, Chigumira, Washington   +2 more
core   +1 more source

Insect models in the study of acetylcholinesterase inhibitors

Archives of Forensic Medicine and Criminology
Organophosphate pesticides inhibit acetylcholinesterase activity, leading to acute cholinergic toxicity in humans. Despite their clinical and forensic relevance, simple and cost-effective invertebrate
Patrycja Zbieralska, Kaja Tusiewicz, Marcin Kadej, Marcin Zawadzki, Paweł Szpot   +4 more
doaj   +1 more source

Antidote administration in mice exposed to sarin resulted in brainwave stabilization without cognitive protection

Neuroscience Research
Resurgence of sarin use in the Syrian conflict demonstrates that chemical weapons are a vivid threat. Like other organophosphate compounds, sarin inhibits acetylcholinesterase resulting in cholinergic crisis.
Mélanie Lagadec, Pauline Thiebot, Isabelle Malissin, Alexandre Champault, Julie Somkhit, Julie Knoertzer, Assia Belkebir, Bruno Megarbane, Karine Thibault, Gregory Dal Bo   +9 more
doaj   +1 more source

THE EFFECTS OF OXIMES IN THE ASSAY OF ACETYLCHOLINESTERASE ACTIVITY IN LYSED ERYTHROCYTES IN VITRO [PDF]

Acta Medica Iranica, 1997
Organophosphorus compounds are known to inhibit the esteratic site of acetylcholinesterase by phosphorylation. The phosphorylated esteratic site of acetylcholinesterase undergoes hydrolytic regeneration at a slow or negligible rate.
M. Abdollahi., Y. Behmanesh M. Akhgari
doaj  

Effect of Gallic Acid on Reactivation of Acetylcholinesterase and Butyrylcholinesterase Inhibited by Diazinon in Vitro and in Vivo

Journal of Mazandaran University of Medical Sciences, 2020
Background and purpose: Diazinon is an organophosphate insecticide that binds to the acetylcholinesterase enzyme after metabolization causing its inactivation. Galic acid is a polyphenolic compound with nucleophilic properties.
Farzaneh Sadat Motafeghi, Mohammad Ali Ebrahimzadeh, Pegah Karbalaei, Hamidreza Mohammadi   +3 more
doaj