Recent Developments in the Ruthenium‐Catalyzed Azide Alkyne Cycloaddition (RuAAC) Reaction
European Journal of Organic Chemistry, Volume 27, Issue 25, July 1, 2024.The Ruthenium‐Catalyzed Azide Alkyne Cycloaddition (RuAAC) provides selective access to both 1,5‐disubstituted and 1,4,5‐trisubstituted 1,2,3‐triazoles in a single step from alkynes and organic azides. The reaction has quickly made its mark in a wide range of areas, spanning from peptidomimetics and antibacterials, to the preparation of functionalized ...
Flavia Ferrara +2 more
wiley +1 more source
Supramolecular Approaches to the Detoxification of Nerve Agents
Israel Journal of Chemistry, Volume 64, Issue 6-7, July 2024.Abstract A promising, but not yet practiced, approach to the treatment of neurotoxic organophosphate poisoning is the administration of a scavenger that rapidly deactivates the nerve agent before it can exert its toxic effects. The detoxification rates required for successful use of this therapy can currently only be achieved with enzymes, but ...
Stefan Kubik
wiley +1 more source
Effect of extract of Varthemia persica DC on whole blood acetylcholinesterase activity in rats [PDF]
, 2016 Varthemia persica DC. is an aromatic plant, from the Asteraceae family, wildly growing in the central provinces of Iran. Sesquiterpene lactones that are found in Varthemia species have protective effect against organophosphates toxicity. This study aimed
Asadi-Samani, Majid. +3 more
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Sociodemographic profile of patients and prescribing trend of drugs in organophosphate poisoning at tertiary care teaching hospital in Central India: a descriptive study [PDF]
, 2019 Background: India is an agrarian country, where pesticides are most widely used in farming. Monsoon dependent agricultural practices are common in India.
Bhagwate, Sudharam T. +4 more
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Sublingual administration of atropine eye drops for treating organophosphorus poisoning
Clinical Case Reports, Volume 12, Issue 5, May 2024.Key Clinical Message An 89‐year‐old patient with fenitrothion toxicity received sublingual atropine eye drops, reducing the intravenous atropine requirement. This alternative method enabled rapid rehabilitation, and he walked unaided, leading to discharge.
Ichiro Hirayama +5 more
wiley +1 more source
Synthesis of o-aryloxime [PDF]
, 2012 An efficient CuI catalyst for the O-arylation of Benzaldoxime with aryl iodide has been developed.Here Benzaldooxime serves as an efficient for C-O cross-coupling thereby allowing for the preparation of O-aryloxime from simple aryl halide.This is a ...
Nayak, Manaswini, Pattnayak, Sagarika
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Development and Evaluation of Combined Drug Formulation for Autoject-injector, for Emergency Application in Organophosphate Poisoning [PDF]
, 2012 Atropine sulphate and pralidoxime chloride are considered as essential antidotes in the treatment of nerve agent poisoning. Now in India these antidotes are available in the form of self injectable autoinjectors.
Jain, Neeti +4 more
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Development of status epilepticus, sustained calcium elevations and neuronal injury in a rat survival model of lethal paraoxon intoxication [PDF]
, 2014 Paraoxon (POX) is an active metabolite of organophosphate (OP) pesticide parathion that has been weaponized and used against civilian populations. Exposure to POX produces high mortality.
Blair, Robert E. +4 more
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Peripheral nervous system and neuromuscular disorders in the emergency department: A review
Academic Emergency Medicine, Volume 31, Issue 4, Page 386-397, April 2024.Abstract Introduction Acute presentations and emergencies in neuromuscular disorders (NMDs) often challenge clinical acumen. The objective of this review is to refine the reader's approach to history taking, clinical localization and early diagnosis, as well as emergency management of neuromuscular emergencies.
Ajith Sivadasan +3 more
wiley +1 more source
Recent Advances in the Treatment of Organophosphorous Poisonings [PDF]
Iranian Journal of Medical Sciences, 2012 Organophosphorous compounds have been employed as pesticides and chemical warfare nerve agents. Toxicity of organophosphorous compounds is a result of excessive cholinergic stimulation through inhibition of acetyl cholinesterase.
Mahdi Balali-Mood, Hamidreza Saber
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