Cyclosarin-An Organophosphate Nerve Agent [PDF]
, 2005 Organophosphorus compounds ascribed to as nerve agents (sarin, soman, tabun, cyclosarin) are highly toxic, and are considered to be the most dangerous chemical compounds.
Krejcova, G., Kuca, K., Sevelova, L.
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Recent advances in cholinergic mechanisms as reactions to toxicity, stress, and neuroimmune insults
Journal of Neurochemistry, Volume 168, Issue 4, Page 355-369, April 2024.We reviewed the current advances in our understanding of the effects of a variety of stressors in order to connect acute poisoning with organophosphates, neurotoxicity, changes in microRNAs, and transfer RNA fragments with cholinergic signaling dysfunction.
Zrinka Kovarik +3 more
wiley +1 more source
A case of fenitrothion self-poisoning with prolonged clinical features
Toxicology CommunicationsBackground Organophosphorus compounds cause toxicity, typically within a few hours following oral exposure, by inhibiting acetylcholinesterase. We report a case of fenitrothion ingestion with delayed onset of severe muscarinic symptoms.Case report A 56 ...
Kaiho Hirata +7 more
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Intensive Care Management of Organophosphate Poisoned Patient: A Test of Critical Care Services in Nigeria [PDF]
, 2013 The management of organophosphate poisoning is challenging, more so in the setting of poor critical care facilities. The management requires the administration of atropine, an antidote (oxime) and supportive care often provided in the ICU.
Akinyemi, OA +3 more
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Journal of Contingencies and Crisis Management, Volume 32, Issue 1, March 2024.Abstract Since 1970, Middle East and North African (MENA) countries have witnessed evolutionary industrial development and long‐running terrorist and inter‐country conflicts. Additionally, the risk of accidental, deliberate or natural chemical, biological, radiological, and nuclear (CBRN) threats has also increased, requiring a collaborative review of ...
Hassan Farhat +18 more
wiley +1 more source
Study on organophosphate poisoning analysis and pharmacotherapeutic outcome in tertiary care hospital [PDF]
, 2016 Background: Organophosphate (OP) poisoning is the most common cause of poisoning and suicides in rural India as it is easily available and more often used in agriculture as a pesticide.
Revankar, Shreenivas P., Vedavathi, H.
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In vitro evaluation of neutral oximes as reactivators of parathion-inhibited electric eel acetylcholinesterase [PDF]
, 2017 Organophosphorus (OP) compounds are irreversible inhibitors of acetylcholinesterase (AChE) commonly used as pesticides and, unfortunately, as nerve agents in terrorist attacks.
Aguiar, Alcino P. +5 more
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Elevation and suppression of paraoxon-induced epileptic activity in the rat hippocampus [PDF]
, 2017 Background: Organophosphorus cholinesterase inhibitors and an elevated extracellular potassium concentration ([K+]e) elicit clinical epilepsy. We investigated (1) the epilepsy-inducing actions of paraoxon (POX) with elevated [K+]e and (2) the effects of ...
Eichi, NARIMATSU +4 more
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Reversal of Cardiovascular Toxicity in Severe Organophosphate Poisoning with 20% Intralipid Emulsion Therapy: Case Report and Review of Literature [PDF]
Asia Pacific Journal of Medical Toxicology, 2014 Background: Cardiac toxicity is one of the life-threatening effects of severe organophosphate (OP) poisoning. We presented a patient with severe OP poisoning, in cardiovascular shock poorly responsive to conventional treatments, who could be resuscitated
Shafat Ahmad Mir, Rafia Rasool
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THE EFFECTS OF OXIMES IN THE ASSAY OF ACETYLCHOLINESTERASE ACTIVITY IN LYSED ERYTHROCYTES IN VITRO [PDF]
Acta Medica Iranica, 1997 Organophosphorus compounds are known to inhibit the esteratic site of acetylcholinesterase by phosphorylation. The phosphorylated esteratic site of acetylcholinesterase undergoes hydrolytic regeneration at a slow or negligible rate.
M. Abdollahi., Y. Behmanesh M. Akhgari
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