Results 51 to 60 of about 1,662,226 (149)

Perampanel as a second‐line therapy to midazolam reduces soman‐induced status epilepticus and neurodegeneration in rats

Epilepsia Open, Volume 10, Issue 4, Page 1187-1198, August 2025.
Abstract Objective A benzodiazepine (diazepam or midazolam) is one of the current standards of care therapies to effectively terminate organophosphorus nerve agent‐induced status epilepticus when administered shortly after onset. Preclinical studies showed that benzodiazepines were less effective in stopping status epilepticus when treatment was ...
Hailey G. Steier, Caroline R. Schultz, Jerome Niquet, Donna A. Nguyen, Michael F. Stone, Abiel K. Biney, Marcio de Araujo Furtado, Claude G. Wasterlain, Lucille A. Lumley   +8 more
wiley   +1 more source

Acute and persistent changes in neural oscillatory activity predict development of epilepsy following acute organophosphate intoxication in adult rats

Epilepsia, Volume 66, Issue 4, Page 1329-1342, April 2025.
Abstract Objective Acute organophosphate (OP) intoxication affects a significant number of individuals worldwide. Those who survive OP‐induced cholinergic crisis, which includes status epilepticus, often develop neurological morbidities. Here, we provide a rigorous characterization of the acute and delayed electrophysiological responses to OP ...
Jeremy A. MacMahon, Peter M. Andrew, Ali Izadi, Donald A. Bruun, Naomi H. Saito, Daniel J. Tancredi, Amy Brooks‐Kayal, Pamela J. Lein, Gene G. Gurkoff   +8 more
wiley   +1 more source

Cardiac damage in acute organophosphate poisoning in rats: Effects of atropine and pralidoxime{star, open}

, 2009
Anticholinesterase poisoning is an important health problem in our country, and a complete understanding of its underlying mechanisms is essential for the emergency physician. Thus, we aimed to investigate the cardiac biochemical parameters and mortality
Demiryurek, Abdullah T., Tarakcioglu, Mehmet, Yildirim, Cuma, Gunay, NURULLAH, Sari, Ibrahim, Kose, Ataman   +5 more
core   +1 more source

Cu‐Based Nanomaterials for Oxime Electrosynthesis: Advances, Challenges, and Perspectives

cMat, Volume 2, Issue 1, March 2025.
ABSTRACT Cu‐based nanomaterials have demonstrated great potential for catalyzing the electrosynthesis of oxime compounds, a type of organonitrogen molecule that finds versatile applications in the pharmaceutical industry, medicine production, chemical feedstocks, and other fields.
Xun‐Ying Liu, Zi‐Yi Liu, Hao‐Zheng Chen, Rui‐Kai Li, Le Li, Zheng‐Hua Tang   +5 more
wiley   +1 more source

Allopregnanolone as an Adjunct Therapy to Midazolam is More Effective Than Midazolam Alone in Suppressing Soman‐Induced Status Epilepticus in Male Rats

CNS Neuroscience &Therapeutics, Volume 31, Issue 3, March 2025.
Acute poisoning with the organophosphate, soman, triggers status epilepticus that rapidly becomes refractory to standard of care treatment with midazolam (MDZ). Combined treatment with MDZ and allopregnanolone (ALLO) significantly suppresses seizure activity, which is associated with attenuated neurodegeneration and neuroinflammation.
Peter M. Andrew, Jeremy A. MacMahon, Xiuzhen Liu, Naomi H. Saito, Kyle E. Berger, Julia E. Morgan, Ashish Dhir, Danielle J. Harvey, Hilary S. McCarren, Michael A. Rogawski, Pamela J. Lein   +10 more
wiley   +1 more source

Smart Sensing of Nerve Agents

ChemPlusChem, Volume 89, Issue 8, August 2024.
Fast and reliable detection of Nerve Agents (NAs) in the environment still represent an urgent need in emergency situation. The development of practical, portable sensing technology, accessible to non‐specialized operators, performing fast detection of NAs, still represents a challenge.
Roberta Puglisi, Rossella Santonocito, Andrea Pappalardo, Giuseppe Trusso Sfrazzetto   +3 more
wiley   +1 more source

Preformulation Studies of Pralidoxime Chloride for Formulation Development of Microspheres [PDF]

, 2019
Microspheres are one of the novel drug delivery system which possess several applications and are made up of assorted polymers. Microspheres can be defined as solid, approximately spherical particles ranging in size from 1 to 1000 μm range in diameter ...
Jain, Suman, Ganesan, K., Sharma, Shyam Bihari   +2 more
core   +1 more source

Oxime Derivatives: A Valid Pharmacophore in Medicinal Chemistry

ChemistrySelect, Volume 9, Issue 27, July 18, 2024.
Oximes are considered as versatile pharmacophores in discovery new class of medicinally active agents. The incorporation of hydroxylamine‐containing moieties to the carbonyl compounds can generate variety oximes. The current review focused on 49 reports, describing about various activities, including antimicrobial, anticancer, anti‐inflammatory ...
Namitha Chandran, Kuntal Bose, Amrutha Chandran Thekkantavida, Riya Rachel Thomas, Karthika Anirudhan, Sandeep Bindra, Sooraj Sura, Haydara Ammar Hasan, Sunil Kumar, T. M. Rangarajan, Abdullah G. Al‐Sehemi, Prashant Gahtori, Hoon Kim, Bijo Mathew   +13 more
wiley   +1 more source

THE PATTERN OF ORGANOPHOSPHORUS COMPOUNDS POISONING AT A TERTIARY CARE TEACHING HOSPITAL AND MEDICAL COLLEGE IN NORTHERN INDIA [PDF]

, 2021
Objective: A retrospective study was conducted in a tertiary care hospital collaborated with a medical college, to analyze the drug therapy including antidotes administered and pattern of Organophosphorous compounds poisoning.
RANJODH JEET SINGH, KANIKA KOHLI
core   +1 more source

Recent Developments in the Ruthenium‐Catalyzed Azide Alkyne Cycloaddition (RuAAC) Reaction

European Journal of Organic Chemistry, Volume 27, Issue 25, July 1, 2024.
The Ruthenium‐Catalyzed Azide Alkyne Cycloaddition (RuAAC) provides selective access to both 1,5‐disubstituted and 1,4,5‐trisubstituted 1,2,3‐triazoles in a single step from alkynes and organic azides. The reaction has quickly made its mark in a wide range of areas, spanning from peptidomimetics and antibacterials, to the preparation of functionalized ...
Flavia Ferrara, Tamás Beke‐Somfai, Nina Kann   +2 more
wiley   +1 more source