Results 71 to 80 of about 2,868 (201)

Recent Developments in the Ruthenium‐Catalyzed Azide Alkyne Cycloaddition (RuAAC) Reaction

European Journal of Organic Chemistry, Volume 27, Issue 25, July 1, 2024.
The Ruthenium‐Catalyzed Azide Alkyne Cycloaddition (RuAAC) provides selective access to both 1,5‐disubstituted and 1,4,5‐trisubstituted 1,2,3‐triazoles in a single step from alkynes and organic azides. The reaction has quickly made its mark in a wide range of areas, spanning from peptidomimetics and antibacterials, to the preparation of functionalized ...
Flavia Ferrara, Tamás Beke‐Somfai, Nina Kann   +2 more
wiley   +1 more source

Nicotine Replacement Combined with a Novel Compound (ProBAN) for Smoking Cessation: A Pilot Study

Canadian Respiratory Journal, 2001
BACKGROUND: Smoking cessation rates with available pharmacological therapies remain suboptimal. Anecdotal observations with a combination of sublingual pralidoxime and ipratropium (ProBAN) suggested that these agents in combination with nicotine gum ...
Richard Leigh, Norman M Viner, Gerard Cox, Jeffrey W Balon, Douglas MC Wilson, Denise O’Shaughnessy, Corinne Walker, Gerry Brosky, Malcolm R Sears   +8 more
doaj   +1 more source

Management of Treatment and Prevention of Acute OP Pesticide Poisoning by Medical Informatics, Telemedicine and Nanomedicine [PDF]

, 2013
Acute organophosphorous pesticide (OP) poisoning kills a lot of people each year. Treatment of acute OP poisoning is of very difficult task and is a time taking event.
Anurag Singh Chauhan, Ganesh Chandra Sahoo, Krishna Pandey, Kumar Gaurav, Manas Ranjan Dikhit, Md. Yousuf Ansari, Mukta Rani, Naresh Kumar Sinha, Pradeep Das, Rishikesh Kumar, Roshan Kamal Topno, Sindhuprava Rana, Vahab Ali, Vidyananda Ravi Das   +13 more
core  

Supramolecular Approaches to the Detoxification of Nerve Agents

Israel Journal of Chemistry, Volume 64, Issue 6-7, July 2024.
Abstract A promising, but not yet practiced, approach to the treatment of neurotoxic organophosphate poisoning is the administration of a scavenger that rapidly deactivates the nerve agent before it can exert its toxic effects. The detoxification rates required for successful use of this therapy can currently only be achieved with enzymes, but ...
Stefan Kubik
wiley   +1 more source

National study on the adequacy of antidotes stocking in Lebanese hospitals providing emergency care [PDF]

, 2016
Background Antidotes stocking is a critical component of hospital care for poisoned patients in emergency. Antidote stocking represents a major health challenge worldwide and in Lebanon.
Al-Bizri, Layla, Al-Helou, Amanda, Deeb, Mary, El-Maamary, Jad, Faour, Wissam H., Ghosn, Nada, Hamade, Rayan, Khammash, Dina, Makhoul, Karim, Mansour, Anthony, Matli, Kamal, Saliba, Elie   +11 more
core   +1 more source

Sublingual administration of atropine eye drops for treating organophosphorus poisoning

Clinical Case Reports, Volume 12, Issue 5, May 2024.
Key Clinical Message An 89‐year‐old patient with fenitrothion toxicity received sublingual atropine eye drops, reducing the intravenous atropine requirement. This alternative method enabled rapid rehabilitation, and he walked unaided, leading to discharge.
Ichiro Hirayama, Yoshito Kamijo, Minaho Nonaka, Tetsuhiro Yano, Mitsuru Ishii, Yoshiteru Tominaga   +5 more
wiley   +1 more source

The Influence of the Time of Antidotal Treatment Administration on Its Effectiveness Against Tabun-Induced Poisoning in Mice

Acta Medica, 2004
Summary: 1. The influence of the time of administration of antidotal treatment consisting of anticholinergic drug (atropine) and oxime (pralidoxime, obidoxime, HI-6 or trimedoxime) on its effectiveness to eliminate tabun-induced lethal effects was ...
Jiří Kassa
doaj   +1 more source

Disentangling the formation, mechanism, and evolvement of the covalent methanesulfonyl fluoride acetylcholinesterase adduct: Insights into an aged‐like inactive complex susceptible to reactivation by a combination of nucleophiles

Protein Science, Volume 33, Issue 5, May 2024.
Abstract Chemical warfare nerve agents and pesticides, known as organophosphorus compounds inactivate cholinesterases (ChEs) by phosphorylating the serine hydroxyl group located at the active site of ChEs. Over the course of time, phosphorylation is followed by loss of an organophosphate‐leaving group and the bond with ChEs becomes irreversible, a ...
Jure Stojan, Alessandro Pesaresi, Anže Meden, Doriano Lamba   +3 more
wiley   +1 more source

A newly developed oxime K203 is the most effective reactivator of tabun-inhibited acetylcholinesterase

BMC Pharmacology and Toxicology, 2018
Background Based on in vitro and in vivo rat experiments, the newly developed acetylcholinesterase (AChE) reactivator, K203, appears to be much more effective in the treatment of tabun poisonings than currently fielded oximes.
Kamil Kuca, Kamil Musilek, Daniel Jun, Jana Zdarova-Karasova, Eugenie Nepovimova, Ondrej Soukup, Martina Hrabinova, John Mikler, Tanos C. C. Franca, Elaine F. F. Da Cunha, Alexandre A. De Castro, Martin Valis, Teodorico C. Ramalho   +12 more
doaj   +1 more source

An Efficient Synthesis of Pyridoxal Oxime Derivatives under Microwave Irradiation [PDF]

, 2014
Quaternary salts of pyridoxal oxime have been synthesized by the quaternization of pyridoxal oxime with substituted phenacyl bromides using microwave heating.
Bušić, Valentina, Cetina, Mario, Gašo-Sokač, Dajana, Jukić, Marijana   +3 more
core   +4 more sources