Results 81 to 90 of about 821 (107)

Design, synthesis, and enhanced reactivation kinetics of nordiazepam-conjugated pyridinium aldoximes as potential bifunctional reactivators against paraoxon-inhibited AChE

open access: yesResults in Chemistry
Organophosphorus (OP) compounds pose a persistent threat through irreversible inhibition of acetylcholinesterase (AChE), leading to cholinergic crisis and central nervous system (CNS) damage.
Mozafar Mohammadi   +2 more
doaj   +1 more source

Potentiometric investigation of the stability of palladium(II) complex of pralidoxime chloride in aqueous solution

open access: yes, 1990
The formation of a complex between palladium(II) chloride and pralidoxime chloride (PAM-2Cl) has been studied by means of potentiometric pH measurements. The real stability constant of the complex in aqueous medium of ionic strength 0.3 M (KCl) at 25.0°C
Karljiković-Rajić, Katarina   +3 more
core   +1 more source

PRESENTATION AND MANAGEMENT OF ORGANOPHOSPHATE POISONING IN AN INTENSIVE CARE UNIT

open access: yesPakistan Armed Forces Medical Journal, 2014
Objective: To determine the various demographic factors, clinical features, management and outcome of organophosphate poisoning in an intensive care unit (ICU) setting. Study Design: Descriptive, quantitative study.
Syed Parvez Asghar   +5 more
doaj   +2 more sources

Avaliação dos efeitos tóxicos induzidos por malation e malaoxon e a possível proteção por oximas [PDF]

open access: yes, 2013
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Bioquímica, Florianópolis, 2013O malation é um composto tóxico pertencente à classe dos pesticidas organofosforados (OF) que tem como ...
Santos, Alessandra Antunes dos
core  

The comparison of therapeutic effects of atropine and pralidoxime on cardiac signs in rats with experimental organophosphate poisoning

open access: yes, 2005
Organophosphate poisoning causes disturbances in cardiac conduction and potentially fatal severe cardiac rhythm abnormalities. This study investigated the cardiac effects of atropine and pralidoxime in the treatment of organophosphate poisoning in rats ...
Demirag, K   +4 more
core   +1 more source

Pralidoxime as antidote in the intoxication of rats with the insecticide metamidophos

open access: yes
O objetivo do presente trabalho foi estudar em ratos, a proteção conferida pela administração de pralidoxima na prevenção da necrose muscular induzida pelo organofosforado metamidofós, em diferentes períodos após a administração.
Santos, Regina Paes dos
core   +1 more source

Intensive Care Management of Organophosphate Poisoned Patient: A Test of Critical Care Services in Nigeria

open access: yesThe Annals of African Surgery, 2013
The management of organophosphate poisoning is challenging, more so in the setting of poor critical care facilities. The management requires the administration of atropine, an antidote (oxime) and supportive care often provided in the ICU.
Osinaike BB, Oranusi IO, Akinniyi O
doaj  

Therapeutic Dosing of Pralidoxime Chloride

open access: yesDrug Intelligence & Clinical Pharmacy, 1987
Pralidoxime chloride is a useful agent in the treatment of organophosphate poisoning. Poisindex, a widely used poisoning treatment resource, recommends dosing pralidoxime chloride as an intermittent iv infusion every 8–12 hours, whereas other authors ...

exaly   +2 more sources

Pharmacokinetic analysis of pralidoxime after its intramuscular injection alone or in combination with atropine-avizafone in healthy volunteers [PDF]

open access: yesBritish Journal of Pharmacology, 2010
BACKGROUND AND PURPOSE Treatment of organophosphate poisoning with pralidoxime needs to be improved. Here we have studied the pharmacokinetics of pralidoxime after its intramuscular injection alone or in combination with avizafone and atropine using an ...
G Lallement
exaly   +2 more sources

Effects of atropine and pralidoxime pretreatment on serum and cardiac oxidative stress parameters in acute dichlorvos toxicity in rats

open access: yesPesticide Biochemistry and Physiology, 2010
Recent several studies have reported that oxidative stress could be an important component of the mechanism of cardiotoxicity due to organophosphate-induced toxicity.
Özcan Bektaş   +2 more
exaly   +2 more sources

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