Results 61 to 70 of about 821 (107)
BMC Pharmacology and Toxicology, 2018 Background Based on in vitro and in vivo rat experiments, the newly developed acetylcholinesterase (AChE) reactivator, K203, appears to be much more effective in the treatment of tabun poisonings than currently fielded oximes.
Kamil Kuca +12 more
doaj +1 more source
Oxime Derivatives: A Valid Pharmacophore in Medicinal Chemistry
ChemistrySelect, Volume 9, Issue 27, July 18, 2024.Oximes are considered as versatile pharmacophores in discovery new class of medicinally active agents. The incorporation of hydroxylamine‐containing moieties to the carbonyl compounds can generate variety oximes. The current review focused on 49 reports, describing about various activities, including antimicrobial, anticancer, anti‐inflammatory ...
Namitha Chandran +13 more
wiley +1 more source
Bioavailability of diazepam after intramuscular injection of its water-soluble prodrug alone or with atropine–pralidoxime in healthy volunteers [PDF]
, 2009 Background and purpose: The aim of this study was to assess the relative bioavailability of diazepam after administration of diazepam itself or as a water-soluble prodrug, avizafone, in humans. Experimental approach: The study was conducted in an open,
C. Abbara +15 more
core +1 more source
Recent Developments in the Ruthenium‐Catalyzed Azide Alkyne Cycloaddition (RuAAC) Reaction
European Journal of Organic Chemistry, Volume 27, Issue 25, July 1, 2024.The Ruthenium‐Catalyzed Azide Alkyne Cycloaddition (RuAAC) provides selective access to both 1,5‐disubstituted and 1,4,5‐trisubstituted 1,2,3‐triazoles in a single step from alkynes and organic azides. The reaction has quickly made its mark in a wide range of areas, spanning from peptidomimetics and antibacterials, to the preparation of functionalized ...
Flavia Ferrara +2 more
wiley +1 more source
Supramolecular Approaches to the Detoxification of Nerve Agents
Israel Journal of Chemistry, Volume 64, Issue 6-7, July 2024.Abstract A promising, but not yet practiced, approach to the treatment of neurotoxic organophosphate poisoning is the administration of a scavenger that rapidly deactivates the nerve agent before it can exert its toxic effects. The detoxification rates required for successful use of this therapy can currently only be achieved with enzymes, but ...
Stefan Kubik
wiley +1 more source
Pharmacokinetic Studies on Oximes in Organophosphate Poisoning: A Mini Review [PDF]
Asia Pacific Journal of Medical Toxicology, 2014 Organophosphate (OP) poisoning is one of the most common causes of poisoning in developing countries especially in Southeastern Asia. Poisoning with phosphorus-containing organic chemicals or OP compounds can be managed with antidotes like oximes which ...
Girish Thunga +6 more
doaj
, 2015 Pralidoxime is an organophosphate antidote with poor central nervous system distribution due to a high polarity. In the present study, pralidoxime-loaded poly(lactic-co-glycolic acid) nanoparticles were prepared and evaluated as a potential delivery ...
Maposa, Prosper +2 more
core +1 more source
This is a data of the study "The effect of pralidoxime on coronary perfusion pressure during cardiopulmonary resuscitation in a pig model". we investigated the effects of pralidoxime administration during cardiopulmonary resuscitation (CPR) in a pig ...
Jeung, Kyung Woon
core +1 more source
, 1961 A satisfactory method for the separation and identification of in vitro breakdown products of pralidoxime iodide (PAM; pyridine-2-aldoxime methiodide; 2-hydroxyiminomethyl-N-metnylpyridinium iodide) by paper chromatographic techniques is ...
David E Easterday, Robert I Ellin
core +1 more source
CHRISMED Journal of Health and Research, 2015 Organophosphorus (OP) compounds have been widely used as pesticide in India. Because of wide use and easy availability, it is the most common poisoning. OP compound poisoning can lead to cardiac complications.
Manoj Lakhotia +4 more
doaj +1 more source