Results 61 to 70 of about 2,059 (195)

Smart Sensing of Nerve Agents

ChemPlusChem, Volume 89, Issue 8, August 2024.
Fast and reliable detection of Nerve Agents (NAs) in the environment still represent an urgent need in emergency situation. The development of practical, portable sensing technology, accessible to non‐specialized operators, performing fast detection of NAs, still represents a challenge.
Roberta Puglisi, Rossella Santonocito, Andrea Pappalardo, Giuseppe Trusso Sfrazzetto   +3 more
wiley   +1 more source

Oxime Derivatives: A Valid Pharmacophore in Medicinal Chemistry

ChemistrySelect, Volume 9, Issue 27, July 18, 2024.
Oximes are considered as versatile pharmacophores in discovery new class of medicinally active agents. The incorporation of hydroxylamine‐containing moieties to the carbonyl compounds can generate variety oximes. The current review focused on 49 reports, describing about various activities, including antimicrobial, anticancer, anti‐inflammatory ...
Namitha Chandran, Kuntal Bose, Amrutha Chandran Thekkantavida, Riya Rachel Thomas, Karthika Anirudhan, Sandeep Bindra, Sooraj Sura, Haydara Ammar Hasan, Sunil Kumar, T. M. Rangarajan, Abdullah G. Al‐Sehemi, Prashant Gahtori, Hoon Kim, Bijo Mathew   +13 more
wiley   +1 more source

The Influence of the Time of Antidotal Treatment Administration on Its Effectiveness Against Tabun-Induced Poisoning in Mice

Acta Medica, 2004
Summary: 1. The influence of the time of administration of antidotal treatment consisting of anticholinergic drug (atropine) and oxime (pralidoxime, obidoxime, HI-6 or trimedoxime) on its effectiveness to eliminate tabun-induced lethal effects was ...
Jiří Kassa
doaj   +1 more source

Recent Developments in the Ruthenium‐Catalyzed Azide Alkyne Cycloaddition (RuAAC) Reaction

European Journal of Organic Chemistry, Volume 27, Issue 25, July 1, 2024.
The Ruthenium‐Catalyzed Azide Alkyne Cycloaddition (RuAAC) provides selective access to both 1,5‐disubstituted and 1,4,5‐trisubstituted 1,2,3‐triazoles in a single step from alkynes and organic azides. The reaction has quickly made its mark in a wide range of areas, spanning from peptidomimetics and antibacterials, to the preparation of functionalized ...
Flavia Ferrara, Tamás Beke‐Somfai, Nina Kann   +2 more
wiley   +1 more source

A newly developed oxime K203 is the most effective reactivator of tabun-inhibited acetylcholinesterase

BMC Pharmacology and Toxicology, 2018
Background Based on in vitro and in vivo rat experiments, the newly developed acetylcholinesterase (AChE) reactivator, K203, appears to be much more effective in the treatment of tabun poisonings than currently fielded oximes.
Kamil Kuca, Kamil Musilek, Daniel Jun, Jana Zdarova-Karasova, Eugenie Nepovimova, Ondrej Soukup, Martina Hrabinova, John Mikler, Tanos C. C. Franca, Elaine F. F. Da Cunha, Alexandre A. De Castro, Martin Valis, Teodorico C. Ramalho   +12 more
doaj   +1 more source

Supramolecular Approaches to the Detoxification of Nerve Agents

Israel Journal of Chemistry, Volume 64, Issue 6-7, July 2024.
Abstract A promising, but not yet practiced, approach to the treatment of neurotoxic organophosphate poisoning is the administration of a scavenger that rapidly deactivates the nerve agent before it can exert its toxic effects. The detoxification rates required for successful use of this therapy can currently only be achieved with enzymes, but ...
Stefan Kubik
wiley   +1 more source

Sublingual administration of atropine eye drops for treating organophosphorus poisoning

Clinical Case Reports, Volume 12, Issue 5, May 2024.
Key Clinical Message An 89‐year‐old patient with fenitrothion toxicity received sublingual atropine eye drops, reducing the intravenous atropine requirement. This alternative method enabled rapid rehabilitation, and he walked unaided, leading to discharge.
Ichiro Hirayama, Yoshito Kamijo, Minaho Nonaka, Tetsuhiro Yano, Mitsuru Ishii, Yoshiteru Tominaga   +5 more
wiley   +1 more source

Cardiac damage in acute organophosphate poisoning in rats: Effects of atropine and pralidoxime{star, open}

, 2009
Anticholinesterase poisoning is an important health problem in our country, and a complete understanding of its underlying mechanisms is essential for the emergency physician. Thus, we aimed to investigate the cardiac biochemical parameters and mortality
Demiryurek, Abdullah T., Tarakcioglu, Mehmet, Yildirim, Cuma, Gunay, NURULLAH, Sari, Ibrahim, Kose, Ataman   +5 more
core   +1 more source

Disentangling the formation, mechanism, and evolvement of the covalent methanesulfonyl fluoride acetylcholinesterase adduct: Insights into an aged‐like inactive complex susceptible to reactivation by a combination of nucleophiles

Protein Science, Volume 33, Issue 5, May 2024.
Abstract Chemical warfare nerve agents and pesticides, known as organophosphorus compounds inactivate cholinesterases (ChEs) by phosphorylating the serine hydroxyl group located at the active site of ChEs. Over the course of time, phosphorylation is followed by loss of an organophosphate‐leaving group and the bond with ChEs becomes irreversible, a ...
Jure Stojan, Alessandro Pesaresi, Anže Meden, Doriano Lamba   +3 more
wiley   +1 more source

Replication Data for: The effect of pralidoxime on coronary perfusion pressure during cardiopulmonary resuscitation in a pig model

This is a data of the study "The effect of pralidoxime on coronary perfusion pressure during cardiopulmonary resuscitation in a pig model". we investigated the effects of pralidoxime administration during cardiopulmonary resuscitation (CPR) in a pig ...
Jeung, Kyung Woon
core   +2 more sources