Results 31 to 40 of about 2,059 (195)

Antidote for organophosphate insecticide poisoning: atropine and pralidoxime [PDF]

, 2013
Acute organophosphate (OP) poisoning produces cholinergic symptoms resulting from the inhibition of cholinesterase, and the overstimulation of muscarinic and nicotinic receptors in the synapses.
정성필
core   +1 more source

Preformulation Studies of Pralidoxime Chloride for Formulation Development of Microspheres [PDF]

, 2019
Microspheres are one of the novel drug delivery system which possess several applications and are made up of assorted polymers. Microspheres can be defined as solid, approximately spherical particles ranging in size from 1 to 1000 μm range in diameter ...
Jain, Suman, Ganesan, K., Sharma, Shyam Bihari   +2 more
core   +1 more source

The Influence of Oxime Selection on the Efficacy of Antidotal Treatment of Soman-Poisoned Rats

Acta Medica, 2002
1. The influence of some acetylcholinesterase reactivators (HI-6, obidoxime, pralidoxime) on the efficacy of antidotal treatment to eliminate soman-induced disturbance of respiration and circulation and to protect experimental animals poisoned with ...
Jiří Kassa, Josef Fusek
doaj   +1 more source

Prevalence of Delayed Neuropathy and Intermediate Syndrome in Acute Organophosphorus Poisoning: A Cross-sectional Toxicological/Clinical Study

International Journal of Medical Toxicology and Forensic Medicine, 2022
Background: Organophosphates are among the most common causes of poisoning worldwide—responsible for 3 million poisoning and 200000 deaths every year. Nearly 15% of people who are poisoned die.
Mitra Rahimi, Rezvan Kefayati, Shahin Shadnia, Peyman Erfan Talab Evini   +3 more
doaj   +1 more source

Pralidoxime Continuous Infusion in the Treatment of Organophosphate Poisoning

, 1997
Objective To report a case of organophosphate poisoning treated with a continuous infusion of pralidoxime chloride. Case Summary A 27-year-old white man presented with extreme agitation, muscle weakness and fasciculations, and respiratory failure after ...
Michael I Anstead, Gretchen M Tush
core   +1 more source

A Comparison of the Neuroprotective and Reactivating Efficacy of a Novel Bispyridinium Oxime K870 with Commonly Used Pralidoxime and the Oxime HI-6 in Tabun-Poisoned Rat

Acta Medica, 2021
Aim: The comparison of neuroprotective and central reactivating effects of the oxime K870 in combination with atropine with the efficacy of standard antidotal treatment in tabun-poisoned rats.
Jiří Kassa, Jana Hatlapatková, Jana Žďárová Karasová, Vendula Hepnarová, Filip Caisberger, Jaroslav Pejchal   +5 more
doaj   +1 more source

Experts' Opinion on Decontamination and Antidote Strategies: Complementing Contemporary Expert Consensus and Evidence to Optimize Preparedness and Response to CBRN Threats in the Middle East and North Africa

Journal of Contingencies and Crisis Management, Volume 34, Issue 1, March 2026.
ABSTRACT Chemical, biological, radiological, and nuclear (CBRN) incidents present escalating challenges, particularly in geopolitically unstable regions such as the Middle East and North Africa. Despite advances, gaps exist regarding optimal decontamination protocols and agent‐specific antidote selection algorithms, exacerbated by variable operational ...
Hassan Farhat, Derrick Tin, Heejun Shin, Saleh Fares Al‐Ali, Daren Mochrie, Brendon Morris, Gregory Ciottone   +6 more
wiley   +1 more source

Succinate prodrugs in combination with atropine and pralidoxime protect cerebral mitochondrial function in a rodent model of acute organophosphate poisoning

Scientific Reports, 2022
Pesticides account for hundreds of millions of cases of acute poisoning worldwide each year, with organophosphates (OPs) being responsible for the majority of all pesticide-related deaths.
Sarah Piel, Joanna I. Janowska, J. Laurenson Ward, Meagan J. McManus, Joshua S. Jose, Jonathan Starr, Malkah Sheldon, Carly L. Clayman, Eskil Elmér, Magnus J. Hansson, David H. Jang, Michael Karlsson, Johannes K. Ehinger, Todd J. Kilbaugh   +13 more
doaj   +1 more source

Acute collapse in a dog with multiple autoimmune syndromes and polymyositis complicated by suspected organophosphate/carbamate toxicity

Veterinary Record Case Reports, Volume 14, Issue 1, February 2026.
Abstract A 6.5‐year‐old, spayed, female dog presented in acute respiratory distress. On admission, the dog exhibited dyspnoea, bradycardia, cyanosis and gastrointestinal signs, requiring immediate intubation and mechanical ventilation. Diagnostic evaluation revealed reduced butyrylcholinesterase activity, non‐cardiogenic pulmonary oedema, elevated ...
Sarah Hefer, Efrat Kelmer, Michal Mazaki Tovi, Dana Peery, Kobi Aharoni, Nir Edry, Sigal Klainbart   +6 more
wiley   +1 more source

Antidote administration in mice exposed to sarin resulted in brainwave stabilization without cognitive protection

Neuroscience Research
Resurgence of sarin use in the Syrian conflict demonstrates that chemical weapons are a vivid threat. Like other organophosphate compounds, sarin inhibits acetylcholinesterase resulting in cholinergic crisis.
Mélanie Lagadec, Pauline Thiebot, Isabelle Malissin, Alexandre Champault, Julie Somkhit, Julie Knoertzer, Assia Belkebir, Bruno Megarbane, Karine Thibault, Gregory Dal Bo   +9 more
doaj   +1 more source