Results 41 to 50 of about 678 (141)

Acetylcholine and Cholinesterase in Submandibular Glands of Rats Given Armin and Obidoxime

, 1978
The effects of obidoxime, a pyridinium oxime, on the cholinesterase activity and acetylcholine content of the submandibular glands of rats poisoned with armin, an organophosphorus anticholinesterase agent, were studied.
Terzić, Milorad R., Bogoslav V. Vasic, Milorad R. Terzic, Milenko P. Milosevic, Milošević, Milenko P., Vasić, Bogoslav V.   +5 more
core   +1 more source

Transport study of adsorptively obidoxime-loaded nanoparticles on an in vitro BBB model.

, 2013
Transport study of adsorptively obidoxime-loaded nanoparticles on an in vitro BBB model.
Jürgen Kufleitner (359212), Anja Zensi (330816), Sylvia Wagner (330815), Tikva Vogel (330820), Franz Worek (262418), Jörg Kreuter (330821), Judith Bungert (359215), Miriam Dadparvar (359213), Sascha Wien (359214), Hagen von Briesen (108749)   +9 more
core   +1 more source

The effects of paraoxon and obidoxime on coagulation.

, 2016
(A) Prothrombin time, (B) Thrombin Time (TT) and (C) activated partial thromboplastin time (APTT) are significantly prolonged by obidoxime as well as by its combination with paraoxon.
Valery Golderman (3186672), Nurit Rosenberg (3186666), Efrat Shavit-Stein (3186678), Yossi Rosman (3186663), Arik Eisenkraft (3186669), Shai Shrot (3186660), Ilia Tamarin (3186675), Nicola Maggio (299719), Joab Chapman (226918)   +8 more
core   +1 more source

The Influence of the Time of Antidotal Treatment Administration on Its Effectiveness Against Tabun-Induced Poisoning in Mice

Acta Medica, 2004
Summary: 1. The influence of the time of administration of antidotal treatment consisting of anticholinergic drug (atropine) and oxime (pralidoxime, obidoxime, HI-6 or trimedoxime) on its effectiveness to eliminate tabun-induced lethal effects was ...
Jiří Kassa
doaj   +1 more source

Experts' Opinion on Decontamination and Antidote Strategies: Complementing Contemporary Expert Consensus and Evidence to Optimize Preparedness and Response to CBRN Threats in the Middle East and North Africa

Journal of Contingencies and Crisis Management, Volume 34, Issue 1, March 2026.
ABSTRACT Chemical, biological, radiological, and nuclear (CBRN) incidents present escalating challenges, particularly in geopolitically unstable regions such as the Middle East and North Africa. Despite advances, gaps exist regarding optimal decontamination protocols and agent‐specific antidote selection algorithms, exacerbated by variable operational ...
Hassan Farhat, Derrick Tin, Heejun Shin, Saleh Fares Al‐Ali, Daren Mochrie, Brendon Morris, Gregory Ciottone   +6 more
wiley   +1 more source

Novel Group of AChE Reactivators—Synthesis, In Vitro Reactivation and Molecular Docking Study

Molecules, 2018
The acetylcholinesterase (AChE) reactivators (e.g., obidoxime, asoxime) became an essential part of organophosphorus (OP) poisoning treatment, together with atropine and diazepam.
David Malinak, Eugenie Nepovimova, Daniel Jun, Kamil Musilek, Kamil Kuca   +4 more
doaj   +1 more source

A newly developed oxime K203 is the most effective reactivator of tabun-inhibited acetylcholinesterase

BMC Pharmacology and Toxicology, 2018
Background Based on in vitro and in vivo rat experiments, the newly developed acetylcholinesterase (AChE) reactivator, K203, appears to be much more effective in the treatment of tabun poisonings than currently fielded oximes.
Kamil Kuca, Kamil Musilek, Daniel Jun, Jana Zdarova-Karasova, Eugenie Nepovimova, Ondrej Soukup, Martina Hrabinova, John Mikler, Tanos C. C. Franca, Elaine F. F. Da Cunha, Alexandre A. De Castro, Martin Valis, Teodorico C. Ramalho   +12 more
doaj   +1 more source

Synthesis, Biological Evaluation, and Docking Studies of Novel Bisquaternary Aldoxime Reactivators on Acetylcholinesterase and Butyrylcholinesterase Inhibited by Paraoxon

Molecules, 2018
Nerve agents and oxon forms of organophosphorus pesticides act as strong irreversible inhibitors of two cholinesterases in the human body: acetylcholinesterase (AChE; EC 3.1.1.7) and butyrylcholinesterase (BChE; EC 3.1.1.8), and are therefore highly ...
Kamil Kuca, Daniel Jun, Lucie Junova, Kamil Musilek, Martina Hrabinova, Jorge Alberto Valle da Silva, Teodorico Castro Ramalho, Marian Valko, Qinghua Wu, Eugenie Nepovimova, Tanos Celmar Costa França   +10 more
doaj   +1 more source

Molecular Modeling and In Vitro Studies of a Neutral Oxime as a Potential Reactivator for Acetylcholinesterase Inhibited by Paraoxon

Molecules, 2018
The present work aimed to compare the small, neutral and monoaromatic oxime, isatin-3-oxime (isatin-O), to the commercial ones, pralidoxime (2-PAM) and obidoxime, in a search for a new potential reactivator for acetylcholinesterase (AChE) inhibited by ...
Reuel L. de Paula, Joyce S. F. D. de Almeida, Samir F. A. Cavalcante, Arlan S. Gonçalves, Alessandro B. C. Simas, Tanos C. C. Franca, Martin Valis, Kamil Kuca, Eugenie Nepovimova, José M. Granjeiro   +9 more
doaj   +1 more source

Cu‐Based Nanomaterials for Oxime Electrosynthesis: Advances, Challenges, and Perspectives

cMat, Volume 2, Issue 1, March 2025.
ABSTRACT Cu‐based nanomaterials have demonstrated great potential for catalyzing the electrosynthesis of oxime compounds, a type of organonitrogen molecule that finds versatile applications in the pharmaceutical industry, medicine production, chemical feedstocks, and other fields.
Xun‐Ying Liu, Zi‐Yi Liu, Hao‐Zheng Chen, Rui‐Kai Li, Le Li, Zheng‐Hua Tang   +5 more
wiley   +1 more source