Results 41 to 50 of about 706 (177)

Electrocardiographic Findings and Prognostic Value of Long QTc Interval in Acute Organophosphate Insecticide Poisoning [PDF]

Ain Shams Journal of Forensic Medicine and Clinical Toxicology, 2015
Organophosphorus (OP) insecticides are one of the most important pesticides, and poisoning induced by them is a major global health problem with about 3 million intoxications and 300,000 deaths occurring worldwide every year.
Ahmad El-Ebiary, Essam Hafez, Mohammed Soliman   +2 more
doaj   +1 more source

Tuning Butyrylcholinesterase Inactivation and Reactivation by Polymer‐Based Protein Engineering

Advanced Science, Volume 7, Issue 1, January 8, 2020., 2020
Butyrylcholinesterase (BChE)‐polymer‐oxime conjugates are synthesized by in situ atom transfer radical polymerization and azide‐alkyne “click” chemistry. The conjugate's activity depends on the electrostatic properties of the polymers and the oxime to BChE ratio.
Libin Zhang, Stefanie L. Baker, Hironobu Murata, Nicholas Harris, Weihang Ji, Gabriel Amitai, Krzysztof Matyjaszewski, Alan J. Russell   +7 more
wiley   +1 more source

Organophosphorus Nerve Agents: Types, Toxicity, and Treatments

Journal of Toxicology, Volume 2020, Issue 1, 2020., 2020
Organophosphorus compounds are extensively used worldwide as pesticides which cause great hazards to human health. Nerve agents, a subcategory of the organophosphorus compounds, have been produced and used during wars, and they have also been used in terrorist activities.
Sudisha Mukherjee, Rinkoo Devi Gupta, Orish Ebere Orisakwe   +2 more
wiley   +1 more source

Acetylcholine content in the brain of rats treated with paraoxon and obidoxime [PDF]

British Journal of Pharmacology, 1970
Summary The effect of obidoxime on the rise in brain acetylcholine caused by the anticholinesterase paraoxon was studied in the rat. In animals poisoned with a sublethal dose of paraoxon and thereafter treated with obidoxime the levels of both “free” and total brain acetylcholine were practically the same as those in rats injected with paraoxon only ...
openaire   +2 more sources

Paraoxon and obidoxime inhibit thrombin activity in vitro.

, 2016
(A) Varying concentrations of paraoxon (500 nM, 5 μM, 28 μM, 50 μM, 0.28 mM and 0.5 mM) inhibit thrombin activity. (B) Obidoxime inhibits thrombin activity at varying concentrations.
Valery Golderman (3186672), Nurit Rosenberg (3186666), Efrat Shavit-Stein (3186678), Yossi Rosman (3186663), Arik Eisenkraft (3186669), Shai Shrot (3186660), Ilia Tamarin (3186675), Nicola Maggio (299719), Joab Chapman (226918)   +8 more
core   +1 more source

The Influence of the Time of Antidotal Treatment Administration on Its Effectiveness Against Tabun-Induced Poisoning in Mice

Acta Medica, 2004
Summary: 1. The influence of the time of administration of antidotal treatment consisting of anticholinergic drug (atropine) and oxime (pralidoxime, obidoxime, HI-6 or trimedoxime) on its effectiveness to eliminate tabun-induced lethal effects was ...
Jiří Kassa
doaj   +1 more source

Experts' Opinion on Decontamination and Antidote Strategies: Complementing Contemporary Expert Consensus and Evidence to Optimize Preparedness and Response to CBRN Threats in the Middle East and North Africa

Journal of Contingencies and Crisis Management, Volume 34, Issue 1, March 2026.
ABSTRACT Chemical, biological, radiological, and nuclear (CBRN) incidents present escalating challenges, particularly in geopolitically unstable regions such as the Middle East and North Africa. Despite advances, gaps exist regarding optimal decontamination protocols and agent‐specific antidote selection algorithms, exacerbated by variable operational ...
Hassan Farhat, Derrick Tin, Heejun Shin, Saleh Fares Al‐Ali, Daren Mochrie, Brendon Morris, Gregory Ciottone   +6 more
wiley   +1 more source

Novel Group of AChE Reactivators—Synthesis, In Vitro Reactivation and Molecular Docking Study

Molecules, 2018
The acetylcholinesterase (AChE) reactivators (e.g., obidoxime, asoxime) became an essential part of organophosphorus (OP) poisoning treatment, together with atropine and diazepam.
David Malinak, Eugenie Nepovimova, Daniel Jun, Kamil Musilek, Kamil Kuca   +4 more
doaj   +1 more source

The effects of paraoxon and obidoxime on coagulation.

, 2016
(A) Prothrombin time, (B) Thrombin Time (TT) and (C) activated partial thromboplastin time (APTT) are significantly prolonged by obidoxime as well as by its combination with paraoxon.
Valery Golderman (3186672), Nurit Rosenberg (3186666), Efrat Shavit-Stein (3186678), Yossi Rosman (3186663), Arik Eisenkraft (3186669), Shai Shrot (3186660), Ilia Tamarin (3186675), Nicola Maggio (299719), Joab Chapman (226918)   +8 more
core   +1 more source

A newly developed oxime K203 is the most effective reactivator of tabun-inhibited acetylcholinesterase

BMC Pharmacology and Toxicology, 2018
Background Based on in vitro and in vivo rat experiments, the newly developed acetylcholinesterase (AChE) reactivator, K203, appears to be much more effective in the treatment of tabun poisonings than currently fielded oximes.
Kamil Kuca, Kamil Musilek, Daniel Jun, Jana Zdarova-Karasova, Eugenie Nepovimova, Ondrej Soukup, Martina Hrabinova, John Mikler, Tanos C. C. Franca, Elaine F. F. Da Cunha, Alexandre A. De Castro, Martin Valis, Teodorico C. Ramalho   +12 more
doaj   +1 more source