Results 61 to 70 of about 706 (177)
Protein Science, Volume 33, Issue 5, May 2024.Abstract Chemical warfare nerve agents and pesticides, known as organophosphorus compounds inactivate cholinesterases (ChEs) by phosphorylating the serine hydroxyl group located at the active site of ChEs. Over the course of time, phosphorylation is followed by loss of an organophosphate‐leaving group and the bond with ChEs becomes irreversible, a ...
Jure Stojan +3 more
wiley +1 more source
Recent advances in cholinergic mechanisms as reactions to toxicity, stress, and neuroimmune insults
Journal of Neurochemistry, Volume 168, Issue 4, Page 355-369, April 2024.We reviewed the current advances in our understanding of the effects of a variety of stressors in order to connect acute poisoning with organophosphates, neurotoxicity, changes in microRNAs, and transfer RNA fragments with cholinergic signaling dysfunction.
Zrinka Kovarik +3 more
wiley +1 more source
Anticholinergic Drugs – Functional Antidotes for the Treatment of Tabun Intoxication
Acta Medica, 2004 Summary: 1. To study the influence of antidotes on tabun-induced neurotoxicity, the rats were injected intramuscularly with organophosphate tabun (LD50).
Gabriela Krejčová, Jiří Kassa
doaj +1 more source
Polarographic reduction of pralidoxime and obidoxime at hanging mercury drop electrode [PDF]
Current World Environment, 2009 The polarographic reduction behavior of Pralidoxime (PRL) and Obidoxime (OBD) at a Hanging Mercury Drop Electrode (HMDE) was exploited for their determination in different samples. Based on the obtained differential pulse polarograms, standard addition method was used to determine these drugs in pharmaceutical formulations and biological fluid samples.
C. NARASIMHA RAO +3 more
openaire +1 more source
Organophosphate Insecticide Poisoning and Parkinsonism
Pediatric Neurology Briefs, 2005 Extrapyramidal parkinsonism in a 14 year-old boy developed 5 days after the accidental ingestion of a raw eggplant sprayed with the organophosphate dimethoate (Rogor), in a report from Meyer Children Hospital, Rappaport School of Medicine, Haifa, Israel.
J Gordon Millichap
doaj +1 more source
Acta Medica, 2006 In the past, scientists focused on the development of antidotes (mainly anticholinergics in combination with reactivators of inhibited acetylcholinesterase – oximes) to increase the number of surviving nerve agent-intoxicated individuals.
Gabriela Kunešová, Jiří Kassa
doaj +1 more source
Acta Medica, 2001 1. The influence of anticholinergic drugs (atropine, benactyzine, biperiden) on the efficacy of monopyridinium and bispyridinium oximes (HI-6, BI-6, obidoxime, pralidoxime, methoxime) on soman-induced supralethal poisoning was studied in mice. 2.
Jiří Kassa
doaj +1 more source
In-vitro Evaluation of Bis-pyridinium Oximes Connected by Xylene Linkers as Reactivators of DFP-inhibited Electric EEL Acetylcholinesterase [PDF]
, 2016 Bis-pyridinium oximes connected by xylene linkers were synthesised and their in-vitro reactivation efficacy was evaluated for DFP inhibited AChE. The reactivation efficacy data were compared with those of 2-PAM and obidoxime.
Raviraju, G +4 more
core +1 more source
Pharmacological applications of azomethine derivatives in the therapy of different diseases [PDF]
PharmaciaCompounds with an azomethine structure belong to different chemical classes—they are hydrazones, phenylhydrazones, semicarbazones, thiosemicarbazones, and oximes.
Ivanka Pencheva +2 more
doaj +3 more sources
Acta Medica, 2010 The studies dealing with mechanism of organophosphates (OP)/nerve agent action, prophylaxis and treatment of intoxications is a very hot topic at present.
Jiří Bajgar
doaj +1 more source