Results 61 to 70 of about 678 (141)

Comparison of Effects of Different Antidotes on Tabun-Induced Cognitive Impairment in Rats Using Water Maze

Acta Medica, 2006
In the past, scientists focused on the development of antidotes (mainly anticholinergics in combination with reactivators of inhibited acetylcholinesterase – oximes) to increase the number of surviving nerve agent-intoxicated individuals.
Gabriela Kunešová, Jiří Kassa
doaj   +1 more source

Spectrophotometric determination of obidoxime chloride as its Pd(II) complex in water and injections

, 1987
It has been established that obidoxime chloride reacts with palladium(II) chloride in the pH range 3.9-8.0 and forms a yellow water-soluble (1:1) complex with maximum absorbance at 355 nm.
Binenfeld, Z.J., Z. Binenfeld, Karljiković-Rajić, Katarina, K. Karljiković-Rajić, B. Stanković, Stanković, B   +5 more
core   +1 more source

The Influence of Anticholinergic Drug Selection on the Effectiveness of Oximes Against Soman-Induced Supralethal Poisoning in Mice

Acta Medica, 2001
1. The influence of anticholinergic drugs (atropine, benactyzine, biperiden) on the efficacy of monopyridinium and bispyridinium oximes (HI-6, BI-6, obidoxime, pralidoxime, methoxime) on soman-induced supralethal poisoning was studied in mice. 2.
Jiří Kassa
doaj   +1 more source

Pharmacological applications of azomethine derivatives in the therapy of different diseases [PDF]

Pharmacia
Compounds with an azomethine structure belong to different chemical classes—they are hydrazones, phenylhydrazones, semicarbazones, thiosemicarbazones, and oximes.
Ivanka Pencheva, Lily Peikova, Dobrina Tsvetkova   +2 more
doaj   +3 more sources

Optimal Choice of Acetylcholinesterase Reactivators for Antidoral Treatment of Nerve Agent Intoxication

Acta Medica, 2010
The studies dealing with mechanism of organophosphates (OP)/nerve agent action, prophylaxis and treatment of intoxications is a very hot topic at present.
Jiří Bajgar
doaj   +1 more source

Case Report of Acute Kidney Injury in Organophosphorus Poisoning and Potential Association with Oxime Use [PDF]

Asia Pacific Journal of Medical Toxicology
Introduction: Organophosphorus poisoning (OP) represents a significant public health issue, particularly in developing countries, due to its extensive availability and high toxicity.
Nourhan Saeed, Rania Youssef, Maram Mostafa   +2 more
doaj   +1 more source

Oxidative stress status assessment of rats' brains injury following subacute exposure to K-oximes

, 2023
Oxidative stress status and morphological injuries in the brain of Wistar rats induced by repeated application of selected acetylcholinesterase reactivators - asoxime, obidoxime, K027, K048, K074, and K075 were evaluated.
Vesna Jaćević, Eugenie Nepovimova, Grujić-Milanović, Jelica, Vojinović, Nataša, Milovanović, Zoran, Dobričić, Vladimir, Dumanović, Jelena, Nežić, Lana, Amidžić, Ljiljana, Marković, Bojan, Ljiljana Amidžić, Bojan Marković, Kuča, Kamil, Jaćević, Vesna, Nataša Vojinović, Petar Milosavljević, Kamil Kuča, Nepovimova, Eugenie, Jelena Dumanović, Zoran Milovanović, Milosavljević, Petar, Lana Nežić, Vladimir Dobričić, Jelica Grujić-Milanović   +23 more
core   +1 more source

Pharmacokinetics and pharmacodynamics of obidoxime in sarin-poisoned rats.

, 1991
The pharmacokinetics and pharmacodynamics of the oxime obidoxime (Toxogonin, 50 mg/kg iv) were investigated in anesthetized normal rats and in sarin-poisoned (50 micrograms/kg iv) rats. The kinetics were described by a two-compartment open model.
Waser PG, Alioth-Streichenberg CM, Bodmer DM   +2 more
core   +1 more source

Reactivation of Human Acetylcholinesterase and Butyrylcholinesterase Inhibited by Leptophos-Oxon with Different Oxime Reactivators in Vitro

, 2010
We have evaluated in vitro the potency of 23 oximes to reactivate human erythrocyte acetylcholinesterase (AChE) and plasma butyrylcholinesterase (BChE) inhibited by racemic leptophos-oxon (O-[4-bromo-2,5-dichlorophenyl]-O-methyl phenyl-phosphonate), a ...
Miroslav Pohanka, Young-Sik Jung, Daniel Jun, Pavel Bostik, Lucie Musilova, Kamil Kuca   +5 more
core   +1 more source

Efficacy of two new asymmetric bispyridinium oximes (K-27 and K-48) in rats exposed to diisopropylfluorophosphate: comparison with pralidoxime, obidoxime, trimedoxime, methoxime, and HI-6

, 2009
Introduction. The new K-oximes, K-27 [1-(4-hydroxyimino-methylpyridinium)-4-(4-carbamoylpyridinium) propane dibromide] and K-48 [1-(4-hydroxyimino-methylpyridinium)-4-(4-carbamoylpyridinium) butane dibromide], show good in vitro efficacy in protecting ...
Hasan, M. Y., Kuca, K., Schmitt, A., Nurulain, S. M., Petroianu, Georg A., Lorke, D. E., K. Kuča, M.Y. Hasan, D.E. Lorke, S.M. Nurulain, A. Schmitt, G.A. Petroianu   +11 more
core   +1 more source