Results 71 to 80 of about 678 (141)

Treatment efficacy in a soman-poisoned guinea pig model: added value of physostigmine? [PDF]

, 2010
Current treatment of organophosphate poisoning is insufficient, and survivors may suffer from long-lasting adverse effects, such as cognitive deficits and sleep-wake disturbances.
van Helden, H.P., Joosen, M.J.A., Smit, A.B., August B. Smit, Herman P. M. van Helden, Marloes J. A. Joosen   +5 more
core   +1 more source

Repetitive obidoxime treatment induced increase of red blood cell acetylcholinesterase activity even in a late phase of a severe methamidophos poisoning: A case report.

, 2016
Accidental self-poisoning or deliberate use in suicidal intent of organophosphorus pesticides (OPP), which are widely used in agriculture, represent a health problem worldwide. Symptoms of poisoning are characterized by acute cholinergic crisis caused by
Steinritz, Dirk;Eyer, Florian;Worek, Franz;Thiermann, Horst;John, Harald
core   +1 more source

Einfluss des Paraoxonase-Phänotyps auf die Abbaugeschwindigkeit hochtoxischer Phosphoryloxime [PDF]

, 2007
Die Fähigkeit der meisten aktiven Pyridinium-4-Aldoxime, wie Obidoxim und Trimedoxime, zur Reaktivierung phosphorylierter Acetylcholinesterase (AChE) ist noch nicht vollständig untersucht, da es zur unvermeidbaren Bildung von Phosphoryloximen (POX) kommt,
Stenzel, Jochen
core   +1 more source

functional interactions of acetylcholine esterase inhibitors and muscarinic receptor antagonists in the urinary bladder of the rat

, 2014
Obidoxime, a weak acetylcholine-esterase (AChE) inhibitor, exerts muscarinic receptor antagonism with a significant muscarinic M2 receptor selective profile.
Vladimir Wsol, Killi, Uday Kumar, Tobin, Gunnar,, Soukup, Ondrej, Michael Winder, Uday K Killi, Winder, Michael,, Wsol, Vladimir, Kuca, Kamil, Ondrej Soukup, Kamil Kuca, Gunnar Tobin   +11 more
core   +1 more source

In Vitro Ability of Currently Available Oximes to Reactivate Organophosphate Pesticide-Inhibited Human Acetylcholinesterase and Butyrylcholinesterase

, 2011
We have in vitro tested the ability of common, commercially available, cholinesterase reactivators (pralidoxime, obidoxime, methoxime, trimedoxime and HI-6) to reactivate human acetylcholinesterase (AChE), inhibited by five structurally different ...
Daniel Jun, Lucie Musilova, Kamil Kuca, Kamil Musilek   +3 more
core   +1 more source

Effect of Several New and Currently Available Oxime Cholinesterase Reactivators on Tabun-intoxicated Rats

, 2008
The therapeutical efficacies of eleven oxime-based acetylcholinesterase reactivators were compared in an in vivo (rat model) study of treatment of intoxication caused by tabun.
Miroslav Pohanka, Young-Sik Jung, Jiri Kassa, Kamil Kuca, Kamil Musilek, Jana Zdarova Karasova   +5 more
core   +1 more source

Insect models in the study of acetylcholinesterase inhibitors

Archives of Forensic Medicine and Criminology
Organophosphate pesticides inhibit acetylcholinesterase activity, leading to acute cholinergic toxicity in humans. Despite their clinical and forensic relevance, simple and cost-effective invertebrate
Patrycja Zbieralska, Kaja Tusiewicz, Marcin Kadej, Marcin Zawadzki, Paweł Szpot   +4 more
doaj   +1 more source

Review of Possible Therapies in Treatment of Novichoks Poisoning and HAZMAT/CBRNE Approaches: State of the Art. [PDF]

J Clin Med, 2023
Noga M, Michalska A, Jurowski K.
europepmc   +1 more source

Preparation and characterisation of phosphonylated oximes

, 2008
Es wurden erstmals phosphonylierte Oxime (POx) durch Direktreaktionen aus Obidoxim und VX, VR und CVX dargestellt. Die Bildungskinetik zeigte eine 100fach höhere Reaktivität des syn-anti- gegenüber dem syn-syn-Obidoxim bei der Reaktion mit VX ...
Becker, Christian
core  

Influence of Experimental End Point on the Therapeutic Efficacy of Essential and Additional Antidotes in Organophosphorus Nerve Agent-Intoxicated Mice. [PDF]

Toxics, 2022
Kassa J, Timperley CM, Bird M, Green AC, Tattersall JEH.   +4 more
europepmc   +1 more source