Results 51 to 60 of about 678 (141)

Nanoparticulate transport of oximes over an in vitro blood-brain barrier model. [PDF]

PLoS ONE, 2010
BACKGROUND: Due to the use of organophosphates (OP) as pesticides and the availability of OP-type nerve agents, an effective medical treatment for OP poisonings is still a challenging problem.
Sylvia Wagner, Jürgen Kufleitner, Anja Zensi, Miriam Dadparvar, Sascha Wien, Judith Bungert, Tikva Vogel, Franz Worek, Jörg Kreuter, Hagen von Briesen   +9 more
doaj   +1 more source

Smart Sensing of Nerve Agents

ChemPlusChem, Volume 89, Issue 8, August 2024.
Fast and reliable detection of Nerve Agents (NAs) in the environment still represent an urgent need in emergency situation. The development of practical, portable sensing technology, accessible to non‐specialized operators, performing fast detection of NAs, still represents a challenge.
Roberta Puglisi, Rossella Santonocito, Andrea Pappalardo, Giuseppe Trusso Sfrazzetto   +3 more
wiley   +1 more source

Oxime Derivatives: A Valid Pharmacophore in Medicinal Chemistry

ChemistrySelect, Volume 9, Issue 27, July 18, 2024.
Oximes are considered as versatile pharmacophores in discovery new class of medicinally active agents. The incorporation of hydroxylamine‐containing moieties to the carbonyl compounds can generate variety oximes. The current review focused on 49 reports, describing about various activities, including antimicrobial, anticancer, anti‐inflammatory ...
Namitha Chandran, Kuntal Bose, Amrutha Chandran Thekkantavida, Riya Rachel Thomas, Karthika Anirudhan, Sandeep Bindra, Sooraj Sura, Haydara Ammar Hasan, Sunil Kumar, T. M. Rangarajan, Abdullah G. Al‐Sehemi, Prashant Gahtori, Hoon Kim, Bijo Mathew   +13 more
wiley   +1 more source

In-vitro Evaluation of Bis-pyridinium Oximes Connected by Xylene Linkers as Reactivators of DFP-inhibited Electric EEL Acetylcholinesterase [PDF]

, 2016
Bis-pyridinium oximes connected by xylene linkers were synthesised and their in-vitro reactivation efficacy was evaluated for DFP inhibited AChE. The reactivation efficacy data were compared with those of 2-PAM and obidoxime.
Raviraju, G, Karade, Hitendra N, Gupta, Arvind Kumar, Acharya, Jyotiranjan, Ghosh, Sanatan   +4 more
core   +1 more source

Supramolecular Approaches to the Detoxification of Nerve Agents

Israel Journal of Chemistry, Volume 64, Issue 6-7, July 2024.
Abstract A promising, but not yet practiced, approach to the treatment of neurotoxic organophosphate poisoning is the administration of a scavenger that rapidly deactivates the nerve agent before it can exert its toxic effects. The detoxification rates required for successful use of this therapy can currently only be achieved with enzymes, but ...
Stefan Kubik
wiley   +1 more source

A Comparison of the Therapeutic Efficacy of Conventional and Modern Oximes Against Supralethal Doses of Highly Toxic Organophosphates in Mice

Acta Medica, 1998
1. The therapeutic efficacy of various oximes (pralidoxime, obidoxime, methoxime, HI-6, HLö-7, BI-6) against supralethal nerve agent poisoning (soman, sarin, cyclosin) in mice was tested. 2. New oxime BI-6, synthesized in our laboratory, is significantly
Jiří Kassa
doaj   +1 more source

Disentangling the formation, mechanism, and evolvement of the covalent methanesulfonyl fluoride acetylcholinesterase adduct: Insights into an aged‐like inactive complex susceptible to reactivation by a combination of nucleophiles

Protein Science, Volume 33, Issue 5, May 2024.
Abstract Chemical warfare nerve agents and pesticides, known as organophosphorus compounds inactivate cholinesterases (ChEs) by phosphorylating the serine hydroxyl group located at the active site of ChEs. Over the course of time, phosphorylation is followed by loss of an organophosphate‐leaving group and the bond with ChEs becomes irreversible, a ...
Jure Stojan, Alessandro Pesaresi, Anže Meden, Doriano Lamba   +3 more
wiley   +1 more source

Recent advances in cholinergic mechanisms as reactions to toxicity, stress, and neuroimmune insults

Journal of Neurochemistry, Volume 168, Issue 4, Page 355-369, April 2024.
We reviewed the current advances in our understanding of the effects of a variety of stressors in order to connect acute poisoning with organophosphates, neurotoxicity, changes in microRNAs, and transfer RNA fragments with cholinergic signaling dysfunction.
Zrinka Kovarik, Gilli Moshitzky, Nikolina Maček Hrvat, Hermona Soreq   +3 more
wiley   +1 more source

Anticholinergic Drugs – Functional Antidotes for the Treatment of Tabun Intoxication

Acta Medica, 2004
Summary: 1. To study the influence of antidotes on tabun-induced neurotoxicity, the rats were injected intramuscularly with organophosphate tabun (LD50).
Gabriela Krejčová, Jiří Kassa
doaj   +1 more source

Organophosphate Insecticide Poisoning and Parkinsonism

Pediatric Neurology Briefs, 2005
Extrapyramidal parkinsonism in a 14 year-old boy developed 5 days after the accidental ingestion of a raw eggplant sprayed with the organophosphate dimethoate (Rogor), in a report from Meyer Children Hospital, Rappaport School of Medicine, Haifa, Israel.
J Gordon Millichap
doaj   +1 more source