Results 81 to 90 of about 678 (141)

Effect of Seven Newly Synthesized and Currently Available Oxime Cholinesterase Reactivators on Cyclosarin-Intoxicated Rats

, 2009
Seven new oxime-based acetylcholinesterase reactivators were compared with three currently available ones (obidoxime, trimedoxime, HI-6) for their ability to lessen cholinesterase inhibition in blood and brain of cyclosarin-treated rats.
Miroslav Pohanka, Jiri Kassa, Ladislav Novotny, Kamil Kuca, Jana Zdarova Karasova, Kamil Musilek   +5 more
core   +1 more source

Experimental and Established Oximes as Pretreatment before Acute Exposure to Azinphos-Methyl. [PDF]

Int J Mol Sci, 2021
Lorke DE, Nurulain SM, Hasan MY, Kuča K, Petroianu GA.   +4 more
europepmc   +1 more source

Quantification of oxidative stress markers in the blood sera following subacute administration of different oximes in rats

Oxidative stress status, as a disruption of redox homeostasis, in the blood sera of Wistar rats caused by repeated application of selected acetylcholinesterase reactivators - asoxime, obidoxime, K027, K048, K074, and K075 were evaluated.
Grujić-Milanović, Jelica, Vojinović, Nataša, Jaćević, Vesna, Milovanović, Zoran, Dobričić, Vladimir, Nežić, Lana, Nepovimova, Eugenie, Amidžić, Ljiljana, Marković, Bojan, Milosavljević, Petar, Kuča, Kamil   +10 more
core   +1 more source

In Vitro Evaluation of Oxidative Stress Induced by Oxime Reactivators of Acetylcholinesterase in HepG2 Cells. [PDF]

Chem Res Toxicol, 2023
Váňová N, Múčková L, Kalíšková T, Lochman L, Bzonek P, Švec F.   +5 more
europepmc   +1 more source

Determination of some pyridinium aldoxime compounds by means of ion-pair reversed-phase high-performance liquid chromatography : Application in biological material

, 1981
Two reversed-phase high-performance liquid chromatographic systems are presented for the separation and assay of the pyridinium aldoximes benzyl-P2A, HI-6 and obidoxime in aqueous solutions and biological samples.
Ligtenstein, D.A., Kossen, S.P., Benschop, H.P., Konings, K.A.G.   +3 more
core  

Editorial: Case reports in predictive toxicology: 2022. [PDF]

Front Pharmacol, 2023
Fröhlich E, Steinritz D.
europepmc   +1 more source

Successful treatment of intermediate syndrome in a COVID-19 patient with severe organophosphate toxicity.

Int J Crit Illn Inj Sci, 2023
Fouad MM, Zawilla NH, Moubarez DA.
europepmc   +1 more source

Assessment of four organophosphorus pesticides as inhibitors of human acetylcholinesterase and butyrylcholinesterase. [PDF]

Sci Rep, 2021
Čadež T, Kolić D, Šinko G, Kovarik Z.   +3 more
europepmc   +1 more source

A New Class of Bi- and Trifunctional Sugar Oximes as Antidotes against Organophosphorus Poisoning. [PDF]

J Med Chem, 2022
Da Silva O, Probst N, Landry C, Hanak AS, Warnault P, Coisne C, Calas AG, Gosselet F, Courageux C, Gastellier AJ, Trancart M, Baati R, Dehouck MP, Jean L, Nachon F, Renard PY, Dias J.   +16 more
europepmc   +1 more source

Efficacy of atropine sulfate/obidoxime chloride co-formulation against sarin exposure in guinea pigs

, 2018
The efficacy and pharmacokinetics of the aqueous co-formulation contents of the Trobigard™ (atropine sulfate, obidoxime chloride) auto-injector were evaluated in a sarin exposed guinea pig model. Two subcutaneous (sc) sarin challenge doses were evaluated
Groningen, T. van, Cornelissen, A.S., Skiadopoulos, M.H., Joosen, M.J.A., Verheij, E., Klaassen, S.D., Shearer, J.D., Cochrane, L.   +7 more
core