Bariatric surgery and brain health: A longitudinal observational study investigating the effect of surgery on cognitive function and gray matter volume [PDF]
, 2020 Dietary modifications leading to weight loss have been suggested as a means to improve brain health. In morbid obesity, bariatric surgery (BARS)—including different procedures, such as vertical sleeve gastrectomy (VSG), gastric banding (GB), or Roux-en-Y
Flöel, A. +7 more
core +1 more source
Preclinical in vivo Neurotoxicity Studies of Drug Candidates
Регуляторные исследования и экспертиза лекарственных средств, 2020 Neurotoxic effects are one of the common reasons for discontinuation of preclinical and/or clinical studies. Preclinical evaluation of neurotoxic effects is complicated due to a wide range of manifestations and degrees of severity.
N. V. Eremina +3 more
doaj +1 more source
Body composition and functional performance of older adults
Osteoporosis and Sarcopenia, 2022 Objectives: To determine if anthropometric variables, body composition, medication and gender are associated with functional performance and to compare these variables between octogenarians with high and low functional performance. Methods: Observational,
Diane Nogueira Paranhos Amorim +4 more
doaj +1 more source
Development of a Functional Observational Battery in the Minipig for Regulatory Neurotoxicity Assessments [PDF]
International Journal of Toxicology, 2017 A functional observational battery (FOB) is recommended as the first-tier neurotoxicity screening in the preclinical safety pharmacology testing guidelines. Minipigs have increasingly been used in regulatory toxicology studies; however, no current FOB protocol is available for neurotoxicity testing in these species. Hence, a minipig FOB instrument was
Miao, Zhong +9 more
openaire +2 more sources
Effect of allopurinol on phosphocreatine recovery and muscle function in older people with impaired physical function:a randomised controlled trial [PDF]
, 2020 Background: Allopurinol has vascular antioxidant effects and participates in purinergic signalling within muscle. We tested whether allopurinol could improve skeletal muscle energetics and physical function in older people with impaired physical ...
Cavin, Ian +10 more
core +2 more sources
Functional changes during hospital stay in older patients admitted to an acute care ward : a multicenter observational study [PDF]
, 2014 Objectives: Changes in physical performance during hospital stay have rarely been evaluated. In this study, we examined functional changes during hospital stay by assessing both physical performance and activities of daily living.
Corsonello, Andrea +6 more
core +2 more sources
Acta Medica, 2016 Aim: The ability of two newly developed oximes (K727, K733) to reduce tabun-induced acute neurotoxic signs and symptoms was evaluated and compared with currently available trimedoxime in rats.
Jiří Kassa +2 more
doaj +1 more source
Acta Medica, 2010 The ability of newly developed oximes (K347, K628) to reduce tabun-induced acute neurotoxic signs and symptoms was compared with currently available oximes (obidoxime, HI-6) using a functional observational battery.
Jiří Kassa +4 more
doaj +1 more source
Effects of spermidine supplementation on cognition and biomarkers in older adults with subjective cognitive decline (SmartAge)—study protocol for a randomized controlled trial [PDF]
, 2019 Background: Given the global increase in the aging population and age-related diseases, the promotion of healthy aging is one of the most crucial public health issues.
Benson, Gloria +18 more
core +2 more sources
Acta Medica, 2003 1. To study the influence of pharmacological pretreatment (PANPAL or pyridostigmine combined with biperiden) and antidotal treatment (the oxime HI-6 plus atropine) on soman-induced neurotoxicity, male albino rats were poisoned with a lethal dose of soman
Jiří Kassa +2 more
doaj +1 more source