Results 231 to 240 of about 3,398,903 (291)

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Artificial Intelligence in Cardiovascular Ultrasound: Clinical Applications, Foundation Models, and the Path to Precision Cardiology. [PDF]

J Clin Med
Tupu AE, Tudor SS, Dumitru CN, Stefan CS, Ferțu ID.   +4 more
europepmc   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

A New Radiological Parameter in Pediatric Lateral Condyle Fractures: How Effective Is Fragment Size? [PDF]

Medicina (Kaunas)
Aman T, Gencer B, Sağlam N, Türkmen İ.   +3 more
europepmc   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Inter-Observer Reliability in Myocardial Blood Flow Measurement Using Rb-82-PET/CT. [PDF]

Tomography
Stolte SJ, Maas OC, Kopp S, Geiger H, Forrer F.   +4 more
europepmc   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Reliability and reproducibility of the STAB classification compared with Neer and AO classifications for proximal humerus fracture-dislocations: a retrospective cohort study of 57 patients. [PDF]

BMC Surg
Gao H, Liu Z, Xu G, Wang Y, Wang J, Ma J, Zhou R, Wang B.   +7 more
europepmc   +1 more source

Proximal Humerus Fractures - A Contemporary Narrative Review of Management Strategies. [PDF]

Orthop Rev (Pavia)
Baig U, Balbisi B, Patel R, Makki D.
europepmc   +1 more source

Radiological Assessment of Atypical Femoral Fractures: A 10-Year Experience Across Two Centres. [PDF]

J Osteoporos
O'Brolchain A, Hughes I, Steer R, Phillips A, Lin CI, Englebrecht Z, Griffin K.   +6 more
europepmc   +1 more source