Results 191 to 200 of about 5,962,243 (238)

Surgical and Functional outcome of Infective Knee Operated with Arthrotomy. [PDF]

J Orthop Case Rep
Shah M, Patel C, Gandhi M, Patel K.
europepmc   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Association of lipoprotein indices with 3-month functional outcome after ischemic stroke: a retrospective cohort study. [PDF]

Front Nutr
Rao Z, Xu C, Yu Y, Zhu G, Liu Y, Wen X, Zhu C, Zhang Y.   +7 more
europepmc   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Associations of plasma MMP-9 and MPO with functional outcome in moderate to severe acute ischemic stroke. [PDF]

Sci Rep
Vogt V, Vollmuth C, Stoll G, Montellano FA, Heuschmann PU, Kollikowski AM, Pham M, Haeusler KG, Neugebauer H, Schuhmann MK.   +9 more
europepmc   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Hemorrhagic Transformation Mediates Stress Hyperglycemia Effect on Functional Outcome in Minor Ischemic Stroke. [PDF]

J Am Heart Assoc
Bax F, Valente M, Mazzacane F, Foschi M, Ornello R, Marè A, Toraldo F, Del Regno C, Sperotto R, Taglialatela A, Del Bello B, Spigariol L, Pavolucci L, Tereshko Y, Gentile C, Janes F, Lorenzut S, Marinig R, Sacco S, Cavallini A, Gigli GL, Merlino G, D'Anna L.   +22 more
europepmc   +1 more source