Results 91 to 100 of about 2,750,599 (310)

Robot-assisted kidney transplantation with regional hypothermia using grafts with Multiple Vessels After Extracorporeal Vascular Reconstruction: results from the European Association of Urology Robotic Urology Section Working Group

, 2018
Background: Kidney transplantation using grafts with multiple vessels (GMVs) is technically demanding and may be associated with increased risk of complications or suboptimal graft function.
Alcaraz, Antonio, Breda, Alberto, Campi, Riccardo, Decaestecker, Karel, Doumerc, Nicolas, Facundo, Carme, Fornara, Paolo, Gausa, Luis, Guirado, Luis, Janssen, Martin, Mohammed, Nasreldin, Musquera, Mireia, Randon, Caren, Sahin, Selcuk, Serni, Sergio, Siena, Giampaolo, Stockle, Michael, Territo, Angelo, Tugcu, Volkan, Vignolini, Graziano   +19 more
core   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Acute care of severely frail elderly patients in a CGA-unit is associated with less functional decline than conventional acute care

Clinical Interventions in Aging, 2017
Niklas Ekerstad,1,2 Synneve Dahlin Ivanoff,3 Sten Landahl,4 Göran Östberg,5 Maria Johansson,5 David Andersson,6 Magnus Husberg,2 Jenny Alwin,2 Björn W Karlson7 1Department of Cardiology, NU (NÄL-Uddevalla) Hospital Group, Trollhä
Ekerstad N, Dahlin Ivanoff S, Landahl S, Östberg G, Johansson M, Andersson D, Husberg M, Alwin J, Karlson BW   +8 more
doaj  

Serum neurofilament light chain: a predictive marker for outcomes following mild-to-moderate ischemic stroke

Frontiers in Neurology
BackgroundBiomarkers that reflect brain damage or predict functional outcomes may aid in guiding personalized stroke treatments. Serum neurofilament light chain (sNfL) emerges as a promising candidate for fulfilling this role.MethodsThis prospective ...
Chongxi Xu, Tong Yi, Ting Qing, Yongliang Jiang, Xingyang Yi, Jianguo Xu, Junpeng Ma   +6 more
doaj   +1 more source

Multilevel functional principal component analysis

, 2009
The Sleep Heart Health Study (SHHS) is a comprehensive landmark study of sleep and its impacts on health outcomes. A primary metric of the SHHS is the in-home polysomnogram, which includes two electroencephalographic (EEG) channels for each subject, at ...
Caffo, Brian S., Crainiceanu, Ciprian M., Di, Chong-Zhi, Punjabi, Naresh M.   +3 more
core   +2 more sources

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Hydroxyapatite ceramic-coated femoral components in younger patients followed up for 27 to 32 years: an update of a previous report

Bone & Joint Open
Aims: This study reports the results of 38 total hip arthroplasties (THAs) in 33 patients aged less than 50 years, using the JRI Furlong hydroxyapatite ceramic (HAC)-coated femoral component.
Piyush K. Upadhyay, Nirav Shah, Vishal Kumar, Saqeb B. Mirza   +3 more
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Presentation and Outcomes After Medical and Surgical Treatment Versus Medical Treatment Alone of Spontaneous Infectious Spondylodiscitis: A Systematic Literature Review and Meta-Analysis. [PDF]

, 2018
Study Design: Systematic literature review. Objectives: The aims of this study were to (1) describe the clinical features, disabilities, and incidence of neurologic deficits of pyogenic spondylodiscitis prior to treatment and (2) compare the functional ...
Buchholz, Avery L, Buell, Thomas J, Chen, Ching-Jen, Diamond, Joshua M, Harrop, James, Nguyen, James H, Shaffrey, Christopher I, Smith, Justin S, Sure, Durga R, Taylor, Davis G, Washburn, Perry A   +10 more
core   +1 more source