Results 161 to 170 of about 5,104,201 (298)

A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy

Molecular Oncology, EarlyView.
Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti, Giovanni Germano, Pietro Paolo Vitiello, Alberto Bardelli   +3 more
wiley   +1 more source

Fatigue effects on angular kinematics in male recreational runners grouped by functional response. [PDF]

Sports Med Open
Encarnación-Martínez A, Sánchez-Ribes E, Bruna-Lázaro R, Sanchis-Sanchis R, Ashby J, Pérez-Soriano P.   +5 more
europepmc   +1 more source

Letter to the Editor: Retinal morphological and functional response to Idebenone therapy in Leber hereditary optic neuropathy. [PDF]

Rom J Morphol Embryol, 2023
Mercuţ MF, Tănasie CA, Nicolcescu AM, Ică OM, Mocanu CL, Dan AO.   +5 more
europepmc   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Qualitative Analysis of a Nonautonomous Delayed Stochastic Predator-Prey Model with Beddington-DeAngelis Functional Response. [PDF]

Biology (Basel)
Jia L, Wang C.
europepmc   +1 more source

Comparison of brain functional response to mechanical prickling stimuli to the glabrous and hairy skin. [PDF]

Skin Res Technol, 2023
Wang Q, Tao Y, Sun T, Yuan J, Ao J, Hong X, Jin Z, Zeng F, Lei Y.   +8 more
europepmc   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Association between cortical thickness and functional response to linguistic processing in the occipital cortex of early blind individuals. [PDF]

Cereb Cortex
Czarnecka M, Hryniewiecka K, Wolna A, Baumbach C, Beck J, Vadlamudi J, Collignon O, Jednoróg K, Szwed M, Stroh AL.   +9 more
europepmc   +1 more source

Complicate dynamical properties of a discrete slow-fast predator-prey model with ratio-dependent functional response. [PDF]

Sci Rep, 2023
Li X, Dong J.
europepmc   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source