Targeting p38α in cancer: challenges, opportunities, and emerging strategies
Molecular Oncology, EarlyView.p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley +1 more source
Factorial scope of ingestion and the potential functional response of puff adders (Bitis arietans) to high prey abundance. [PDF]
Sci RepAlexander GJ.
europepmc +1 more source
Functional response of <i>Neoseiulus californicus</i> (Acari: Phytoseiidae) to <i>Tetranychus urticae</i> (Acari: Tetranychidae) at different temperatures. [PDF]
PeerJ, 2023 Mumtaz M +6 more
europepmc +1 more source
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Effect of temperature on functional response of Blattisocius mali (Acari: Blattisociidae) preying on the acarid mite Tyrophagus putrescentiae. [PDF]
Sci RepMichalska K, Jena MK, Studnicki M.
europepmc +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Functional response of Anystis baccarum (Acari: Anystidae) preying on two raspberry pests: Aphis idaei (Hemiptera: Aphididae) and Neotetranychus rubi (Acari: Tetranychidae). [PDF]
J Econ EntomolTan JL, Zemek R.
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spectrometer response function
Citation: 'spectrometer response function' in the IUPAC Compendium of Chemical Terminology, 5th ed.; International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.09283 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for ...
openaire +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Daily Prey Consumption and Functional Response of Orius insidiosus: Implications for Biological Control of Scirtothrips dorsalis in Strawberries. [PDF]
InsectsAdhikary L, Smith HA, Lahiri S.
europepmc +1 more source