Results 171 to 180 of about 6,065,144 (355)

Biocatalytic Nanoregulators Restore Joint Redox‐Immune Homeostasis in Rheumatoid Arthritis

Advanced Science, EarlyView.
Mesenchymal stem cell‐derived extracellular vesicles (EVs) coat ruthenium‐loaded metal‐organic frameworks (Ru@ZrMOF), creating a targeted therapeutic (Ru@ZrMOF/EVs). This platform scavenges ROS, generates oxygen, and polarizes macrophages from M1 to M2, alleviating inflammation, inhibiting pannus, promoting cartilage repair, and downregulating HIF‐1α ...
Xingheng Wang, Jianbo Huang, Shuwei Zhang, Sujiao Cao, Fangxue Du, Liqiang Zhou, Li Qiu, Yuanjiao Tang   +7 more
wiley   +1 more source

Pre‐Encoded IFN‐I Sensitivity Exacerbates Memory T Cell Senescence in Solid Tumors

Advanced Science, EarlyView.
Type I interferon (IFN‐I) signaling promotes p21‐dependent cell cycle arrest in senescent tumor‐specific memory T cells, resulting in poor proliferative responses and solid tumor regression during cancer vaccination. Conversely, IFNα/β receptor blockade reinvigorates T cell proliferation to regress solid tumors and is more effective with increasing ...
Andrew Nguyen, Scott R Walsh, Li Deng, Lan Chen, Yonghong Wan   +4 more
wiley   +1 more source

Inferential tests and modelling of functional trait convergence along environmental gradients [PDF]

, 2013
The motivation for this paper comes from a recent study which indicated that the influence of environmental filtering should increase with decreasing soil fertility, based on the premise that individuals will employ a resource-retentive strategy in a ...
Brown, Paul T., Joshi, Chaitanya, Laughlin, Daniel C.   +2 more
core   +1 more source

Mitochondrial Calcium Uniporter Drives Chemoresistance in Pancreatic Cancer via Glutathione‐Mediated Stemness Maintenance

Advanced Science, EarlyView.
PDAC has a poor prognosis due to chemoresistance. We revealed that MCU upregulation is associated with chemoresistance and stemness in PDAC. MCU‐mediated Ca2+ influx induced ER stress, activating the PERK‐ATF4/NRF2 axis to enhance PSAT1/SLC711 expression and glutathione synthesis, reducing ROS and maintaining stemness.
Zekun Li, Chenyang Meng, Guangcong Shen, Yueying Shan, Junjin Wang, Diliyaer Abudukeremu, Rui Zhao, Bo Ni, Chao Xu, Xiaofan Guo, Jun Yu, Kaiyuan Wang, Shengyu Yang, YunZhan Li, Yongjie Xie, Tianxing Zhou, Jihui Hao, Xiuchao Wang   +17 more
wiley   +1 more source

Stochastic Nanoscale Biophysical Cues as a Basis for the Induction of Glioblastoma‐Like Transcriptional Programs in Astrocytes

Advanced Science, EarlyView.
Stochastic nanoscale physical cues induce glioblastoma (GBM)‐associated transcriptional traits in naïve astrocytes leading to spontaneous formation of spheroids. Cells within spheroids express activated‐MMP2 and a differential gene expression pattern involving P53 and NOTCH3, providing evidence for a role for changes in brain topography, as observed in
Laurent Starck, Tobias Butelmann, Sabrina Hogan, Melika Sarem, Bernd Heimrich, Ritwick Sawarkar, Marie‐Françoise Ritz, Gregor Hutter, V. Prasad Shastri   +8 more
wiley   +1 more source

Microbiota as Potential Functional Traits Facilitating Springtail Activity in Winter

Ecology and Evolution
Understanding the role of microbiota in supporting animal survival and activity under extreme environmental conditions provides valuable insights into adaptation and resilience mechanisms in ecosystems.
Cao Hao, Bing Zhang, Pingting Guan, Zhijing Xie, Guoliang Xu, Donghui Wu, Ting‐Wen Chen   +6 more
doaj   +1 more source

Environmental filtering and dispersal limitation jointly shape the taxonomic, functional and phylogenetic diversity in a subtropical karst forest of China

Frontiers in Plant Science
IntroductionCommunity assembly involves species forming communities through interactions and environmental adaptation, with traits and phylogeny playing key roles.
Qingzhi Long, Qingzhi Long, Qingzhi Long, Zhili Zhan, Zhili Zhan, Zhili Zhan, Hu Du, Hu Du, Hu Du, Wanxia Peng, Wanxia Peng, Wanxia Peng, Liang Su, Liang Su, Hao Zhang, Hao Zhang, Zhaoxia Zeng, Zhaoxia Zeng, Fuping Zeng, Fuping Zeng, Weining Tan, Youwang Mo, Xichao Deng, Yanjun Xie, Kelin Wang, Kelin Wang   +25 more
doaj   +1 more source

Unveiling Global Diversity of Patescibacteriota and Functional Interactions with Host Microbes

Advanced Science, EarlyView.
Patescibacteriota represents a diverse group of ultra‐small epibiotic bacteria, which is largely overlooked. By integrating ribosomal protein S3‐based community profiling with MAG‐based metabolic potential analyses, this study provides new insights into their distribution, diversity, and potential interactions with other bacteria across diverse ...
Yanhan Ji, Xu Liu, Shuai Zhao, Sihan Zhou, Yufan Yang, Ping Zhang, Yu Shi, Wei Qin, Guibing Zhu, Yongguan Zhu, Yanzheng Gao, Jiandong Jiang, Baozhan Wang   +12 more
wiley   +1 more source

Decoding Human Placental Cellular and Molecular Responses to Obesity and Fetal Growth

Advanced Science, EarlyView.
Women with obesity often deliver large‐for‐gestational‐age (LGA) infants. Single‐nucleus RNA sequencing of term placenta reveals that hypoxia and TNF‐α signaling in syncytiotrophoblasts are featured in maternal obesity, but inflammatory signatures in Hofbauer cells and response to lipid or carbohydrate metabolism in fibroblasts are specific to LGA.
Hong Jiang, Emilie Derisoud, Denise Parreira, Nayere Taebnia, Paulo R. Jannig, Reza Zandi Shafagh, Allan Zhao, Congru Li, Macarena Ortiz, Manuel Alejandro Maliqueo, Elisabet Stener‐Victorin, Volker M. Lauschke, Qiaolin Deng   +12 more
wiley   +1 more source

Which contributes more in predictor of desert shrubs traits: Intra-annual or inter-annual precipitation change?

Ecological Indicators
Considering the implications of future climatic shifts, mid-latitude desert ecosystems will experience pronounced changes in precipitation dynamics, as evidenced by the elevated inter-annual variability and escalated annual incidence of extreme rainfall ...
Fuchong Zhang, Minghan Yu, Jianling Zhang, Yingying He, Guodong Ding   +4 more
doaj   +1 more source