Results 181 to 190 of about 247,513 (260)

FUCA2 Sustains AKT Signaling and Suppresses Senescence by Antagonizing FUT3‐Mediated ErbB3 Fucosylation in Lung Adenocarcinoma

Advanced Science, EarlyView.
ABSTRACT While targeted therapies have improved outcomes in lung adenocarcinoma (LUAD), many patients still lack targetable mutations. Here, we identified alpha‐L‐fucosidase 2 (FUCA2) as a crucial driver of LUAD by preventing cellular senescence. Mechanistically, through the restriction of fucosyltransferase 3 (FUT3)‐mediated α‐1,3‐fucosylation of ...
Lu Chen, Jintao Guo, Fei Li, Mingjie Gao, Runyang Li, Zhaozhang Huang, Yaolin Zheng, Chunyi Gao, Jihuan Hou, Qiang Yu, Bowen Zheng, Xuemei Chen, Wenqing Zhang, Xiaoting Hong, Yali Zheng, Daxuan Wang, Qiyuan Li, Tianhui Hu, Yan‐yan Zhan   +18 more
wiley   +1 more source

Functional trait variations of the invasive plant Alternanthera Philoxeroides and the native plant Ludwigia peploides under nitrogen addition. [PDF]

Sci Rep
Li D, Lv T, Li Y, Yu H, Yu D, Liu C.
europepmc   +1 more source

Morphological and functional trait divergence in endemic fish populations along the small-scale karstic stream. [PDF]

BMC Zool, 2023
Acar E, Kaymak N.
europepmc   +1 more source

Cross‐Modal Denoising and Integration of Spatial Multi‐Omics Data with CANDIES

Advanced Science, EarlyView.
In this paper, we introduce CANDIES, which leverages a conditional diffusion model and contrastive learning to effectively denoise and integrate spatial multi‐omics data. We conduct extensive evaluations on diverse synthetic and real datasets, CANDIES shows superior performance on various downstream tasks, including denoising, spatial domain ...
Ye Liu, Wanpeng Zou, Yuekai Li, Jiayi Wang, Mingxuan Cai, Hongmin Cai   +5 more
wiley   +1 more source

Canopy functional trait variation across Earth's tropical forests. [PDF]

Nature
Aguirre-Gutiérrez J, Rifai SW, Deng X, Ter Steege H, Thomson E, Corral-Rivas JJ, Guimaraes AF, Muller S, Klipel J, Fauset S, Resende AF, Wallin G, Joly CA, Abernethy K, Adu-Bredu S, Alexandre Silva C, de Oliveira EA, Almeida DRA, Alvarez-Davila E, Asner GP, Baker TR, Benchimol M, Bentley LP, Berenguer E, Blanc L, Bonal D, Bordin K, Borges de Lima R, Both S, Cabezas Duarte J, Cardoso D, de Lima HC, Cavalheiro L, Cernusak LA, Dos Santos Prestes NCC, da Silva Zanzini AC, da Silva RJ, Dos Santos Alves da Silva R, de Andrade Iguatemy M, De Sousa Oliveira TC, Dechant B, Derroire G, Dexter KG, Rodrigues DJ, Rodrigues DJ, Espírito-Santo M, Silva LF, Domingues TF, Ferreira J, Simon MF, Girardin CAJ, Hérault B, Jeffery KJ, Kalpuzha Ashtamoorthy S, Kavidapadinjattathil Sivadasan A, Klitgaard B, Laurance WF, Dan ML, Magnusson WE, Campos-Filho EM, Manoel Dos Santos R, Manzatto AG, Silveira M, Marimon-Junior BH, Martin RE, Vieira DLM, Metzker T, Milliken W, Moonlight P, Moraes de Seixas MM, Morandi PS, Muscarella R, Nava-Miranda MG, Nyirambangutse B, Silva JO, Oliveras Menor I, Francisco Pena Rodrigues PJ, Pereira de Oliveira C, Pereira Zanzini L, Peres CA, Punjayil V, Quesada CA, Réjou-Méchain M, Riutta T, Rivas-Torres G, Rosa C, Salinas N, Bergamin RS, Marimon BS, Shenkin A, Silva Rodrigues PM, Figueiredo AES, Garcia QS, Spósito T, Storck-Tonon D, Sullivan MJP, Svátek M, Vieira Santiago WT, Arn Teh Y, Theruvil Parambil Sivan P, Nascimento MT, Veenendaal E, Zo-Bi IC, Dago MR, Traoré S, Patacca M, Badouard V, de Padua Chaves E Carvalho S, White LJT, Zhang-Zheng H, Zibera E, Zwerts JA, Burslem DFRP, Silman M, Chave J, Enquist BJ, Barlow J, Phillips OL, Coomes DA, Malhi Y.   +119 more
europepmc   +1 more source

Multi‐Omics Insights Into the Mechanisms of Early Muscle Fiber Difference and Transformation Between Lean‐Type and Chinese Indigenous Pigs

Advanced Science, EarlyView.
Multi‐omics analyses uncover breed‐specific cis‐regulatory landscapes and higher‐order chromatin architectural differences that underlie early postnatal muscle fiber divergence in pigs. A super‐enhancer upstream of PPP3CB recruits MEF2C to activate PPP3CB transcription, while the PPP3CB–MEF2C positive feedback loop promotes oxidative muscle fiber ...
Shuailong Zheng, Hainan Wu, Min Liu, Kunpeng Wu, Shuntao Huang, Zulfiqar Ahmed, Lenox Pius, Mengjin Zhu, Dequan Xu   +8 more
wiley   +1 more source

Leaf functional trait dataset of 93 dominant woody species from the central Western Ghats, India. [PDF]

Data Brief
Bhat M, Raghavendra S, Rajendiran G, Bhat VS, Pujari A, Pai V, Vastrad N, Kumara HN, Pandi V.   +8 more
europepmc   +1 more source

DTX3L Inhibits the EMT, Metastasis, and Stem‐Like Features of Gastric Cancer Through Promoting GSK‐3β Dependent SNAI1 Decay

Advanced Science, EarlyView.
This research identifies DTX3L as a critical tumor suppressor that inhibits epithelial‐mesenchymal transition (EMT), invasion and metastasis in gastric cancer. By functioning as an E3 ubiquitin ligase, DTX3L targets the master EMT regulator SNAI1 for GSK‐3β‐dependent proteasomal degradation.
Yang Chen, Zhen Li, Jiajia Shen, Jingyu Lin, Xiaoli Zhao, Rui Zhang, Ying Han, Zhen Wang   +7 more
wiley   +1 more source

Growth Performance Is Driven by Site Conditions and Moderated by Functional Trait Plasticity in <i>Quercus robur</i> and <i>Prunus avium</i>. [PDF]

Ecol Evol
Di Fabio A, Aspalter S, Chakraborty D, van Loo M, Rolke LM, Schüler S, Thiel R, Veit C, Kreyling J.   +8 more
europepmc   +1 more source

Introgressed Variation in TaMYB7‐A1 Drives Graded Dormancy and Climate‐Adaptive Pre‐Harvest Sprouting Resistance in Wheat

Advanced Science, EarlyView.
TaMYB7‐A1 directly activates TaABI5 to enhance ABA signaling and regulate ABA‐GA homeostasis, enforcing seed dormancy. Its superior allele, derived from wild einkorn introgression, harbors a MITE insertion that elevates expression and two amino acid substitutions that enhance transcriptional activity, collectively generating graded PHS resistance for ...
Hao Wang, Dongzhi Wang, Yafei Guo, Qi Zheng, Min Zhang, James Simmonds, Jian Hou, Xuemei Liu, Xuelei Lin, Xiaomin Bie, Xiansheng Zhang, Xiaohui Li, Yuan Chen, Xueyong Zhang, Cristobal Uauy, Fei Lu, Chengcai Chu, Zhixi Tian, Jun Xiao   +18 more
wiley   +1 more source